TH and STIM1

		TH	STIM1
Description		tyrosine hydroxylase	stromal interaction molecule 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Smooth Endoplasmic Reticulum Cytosol Synaptic Vesicle Cytoplasmic Side Of Plasma Membrane Axon Cytoplasmic Vesicle Melanosome Membrane Cell Projection Neuron Projection Perikaryon Synapse Perinuclear Region Of Cytoplasm	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytoskeleton Microtubule Plasma Membrane Membrane Sarcoplasmic Reticulum Cortical Endoplasmic Reticulum Sarcoplasmic Reticulum Membrane Plasma Membrane Raft
	Molecular Function	Monooxygenase Activity Tyrosine 3-monooxygenase Activity Iron Ion Binding Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Pteridine As One Donor, And Incorporation Of One Atom Of Oxygen Enzyme Binding Identical Protein Binding Metal Ion Binding	Protease Binding Calcium Channel Regulator Activity Calcium Ion Binding Protein Binding Identical Protein Binding Metal Ion Binding Microtubule Plus-end Binding
	Biological Process	Response To Hypoxia Synaptic Transmission, Dopaminergic Heart Morphogenesis Dopamine Biosynthetic Process From Tyrosine Heart Development Visual Perception Learning Memory Mating Behavior Locomotory Behavior Regulation Of Heart Contraction Aromatic Amino Acid Metabolic Process Anatomical Structure Morphogenesis Animal Organ Morphogenesis Dopamine Biosynthetic Process Epinephrine Biosynthetic Process Norepinephrine Biosynthetic Process Catecholamine Biosynthetic Process Serotonin Biosynthetic Process Eye Photoreceptor Cell Development Eating Behavior Pigmentation Response To Ethanol Embryonic Camera-type Eye Morphogenesis Cognition Hyaloid Vascular Plexus Regression	Store-operated Calcium Entry Detection Of Calcium Ion Monoatomic Ion Transport Calcium Ion Transport Intracellular Calcium Ion Homeostasis Activation Of Store-operated Calcium Channel Activity Positive Regulation Of Adenylate Cyclase Activity Positive Regulation Of Angiogenesis Regulation Of Calcium Ion Transport Enamel Mineralization Regulation Of Store-operated Calcium Entry
Pathways		Catecholamine biosynthesis	Elevation of cytosolic Ca2+ levels Ion homeostasis Ion homeostasis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs		Phenylalanine Tyrosine Sapropterin Metyrosine 3-Tyrosine L-erythro-7,8-dihydrobiopterin
Diseases		Primary torsion dystonia (PTD)
GWAS		Celiac disease ( 23936387) Height ( 31562340) Hematocrit ( 32888494) Hemoglobin ( 32888494) Iron status biomarkers (ferritin levels) ( 33536631) Prostate cancer ( 19767753) Prostate cancer (early onset) ( 24740154) Prostate cancer (SNP x SNP interaction) ( 22219177) Severe autoimmune type 2 diabetes ( 34737425) Type 1 diabetes autoantibodies in high risk HLA genotype individuals (time to event) ( 29310926) Type 1 diabetes in high risk HLA genotype individuals (time to event) ( 29310926) Type 2 diabetes ( 25102180 31324766)	Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Calcium levels ( 29403010) Disruptive behavior disorder and attention deficit hyperactivity disorder ( 33495439) Hemoglobin ( 32888494) Malaria ( 31844061) Mean corpuscular volume ( 32888494) Mean platelet volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Platelet distribution width ( 27863252 32888494) Systemic lupus erythematosus ( 33272962) Waist circumference ( 34074324)
Interacting Genes		22 interacting genes: CAMK2G CDK11B CRABP1 CSNK2A1 DAAM2 HNRNPK MAPK1 MAPK3 MAPKAPK2 MDFI PIAS2 PRKACA PUF60 RBMY1A1 RPS6KA5 SNCA TSPYL4 TYSND1 UMAD1 YWHAB YWHAZ ZNF569	6 interacting genes: IFNGR1 INSIG2 RABAC1 SLC7A1 STIM2 TSPAN18
Entrez ID		7054	6786
HPRD ID		01865	05803
Ensembl ID		ENSG00000180176	ENSG00000167323
Uniprot IDs		P07101 P78428	A0A8V8TMF0 A0A8V8TMG1 A0A8V8TNW0 A0A8V8TP73 E9PRZ7 G0XQ39 H0YDB2 Q13586
PDB IDs		2XSN 4J6S 6ZN2 6ZVP 6ZZU 7A2G 7PIM	2K60 2MAJ 2MAK 3TEQ 4O9B 6YEL
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Protein Serine Kinase Activity Regulation Of Primary Metabolic Process Protein Serine/threonine Kinase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Sequestering Activity Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Protein Kinase Activity TORC1 Signaling Interleukin-34-mediated Signaling Pathway Kinase Activity Negative Regulation Of Macromolecule Metabolic Process TOR Signaling Regulation Of Golgi Inheritance Negative Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Protein Phosphorylation Regulation Of RNA Biosynthetic Process Negative Regulation Of Metabolic Process Insulin-like Growth Factor Receptor Signaling Pathway Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Regulation Of Protein Stability Phosphoserine Residue Binding Protein Domain Specific Binding Negative Regulation Of Catabolic Process Phosphorylation Regulation Of Multicellular Organismal Process Cardiac Neural Crest Cell Development Involved In Heart Development Trachea Formation Regulation Of Signal Transduction Phosphotyrosine Residue Binding Regulation Of Cell Communication Regulation Of Signaling Regulation Of MRNA Processing Focal Adhesion Outer Ear Morphogenesis ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Long-term Synaptic Potentiation Nucleus ERK1 And ERK2 Cascade Bergmann Glial Cell Differentiation Epidermal Growth Factor Receptor Signaling Pathway Cellular Response To Epinephrine Stimulus	Type II Interferon Receptor Activity Ribonucleoside-diphosphate Reductase Complex Positive Regulation Of G0 To G1 Transition Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Purine Nucleotide Binding Ribonucleoside-diphosphate Reductase Activity Ornithine Transport L-lysine Transmembrane Transporter Activity L-histidine Transmembrane Transporter Activity Lysine Transport L-ornithine Transmembrane Transport L-histidine Transmembrane Transport L-ornithine Transmembrane Transporter Activity L-arginine Import Across Plasma Membrane L-histidine Import Across Plasma Membrane Synaptic Vesicle Serotonin Biosynthetic Process Epinephrine Biosynthetic Process Epinephrine Metabolic Process Tyrosine 3-monooxygenase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Pteridine As One Donor, And Incorporation Of One Atom Of Oxygen Dopamine Biosynthetic Process From Tyrosine Negative Regulation Of SREBP Signaling Pathway SREBP-SCAP-Insig Complex SREBP-SCAP Complex Retention In Endoplasmic Reticulum Activation Of Store-operated Calcium Channel Activity L-lysine Transmembrane Transport Hyaloid Vascular Plexus Regression Positive Regulation Of Store-operated Calcium Channel Activity
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