TH and RNH1

		TH	RNH1
Description		tyrosine hydroxylase	ribonuclease/angiogenin inhibitor 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Smooth Endoplasmic Reticulum Cytosol Synaptic Vesicle Cytoplasmic Side Of Plasma Membrane Axon Cytoplasmic Vesicle Melanosome Membrane Cell Projection Neuron Projection Perikaryon Synapse Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Lamellipodium Angiogenin-PRI Complex Extracellular Exosome
	Molecular Function	Monooxygenase Activity Tyrosine 3-monooxygenase Activity Iron Ion Binding Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Pteridine As One Donor, And Incorporation Of One Atom Of Oxygen Enzyme Binding Identical Protein Binding Metal Ion Binding	Protein Binding Ribonuclease Inhibitor Activity
	Biological Process	Response To Hypoxia Synaptic Transmission, Dopaminergic Heart Morphogenesis Dopamine Biosynthetic Process From Tyrosine Heart Development Visual Perception Learning Memory Mating Behavior Locomotory Behavior Regulation Of Heart Contraction Aromatic Amino Acid Metabolic Process Anatomical Structure Morphogenesis Animal Organ Morphogenesis Dopamine Biosynthetic Process Epinephrine Biosynthetic Process Norepinephrine Biosynthetic Process Catecholamine Biosynthetic Process Serotonin Biosynthetic Process Eye Photoreceptor Cell Development Eating Behavior Pigmentation Response To Ethanol Embryonic Camera-type Eye Morphogenesis Cognition Hyaloid Vascular Plexus Regression	Cytoplasmic Translation MRNA Catabolic Process Cell Migration Negative Regulation Of Translation In Response To Stress Regulation Of Arp2/3 Complex-mediated Actin Nucleation TRNA Stabilization Regulation Of Angiogenesis
Pathways		Catecholamine biosynthesis
Drugs		Phenylalanine Tyrosine Sapropterin Metyrosine 3-Tyrosine L-erythro-7,8-dihydrobiopterin
Diseases		Primary torsion dystonia (PTD)
GWAS		Celiac disease ( 23936387) Height ( 31562340) Hematocrit ( 32888494) Hemoglobin ( 32888494) Iron status biomarkers (ferritin levels) ( 33536631) Prostate cancer ( 19767753) Prostate cancer (early onset) ( 24740154) Prostate cancer (SNP x SNP interaction) ( 22219177) Severe autoimmune type 2 diabetes ( 34737425) Type 1 diabetes autoantibodies in high risk HLA genotype individuals (time to event) ( 29310926) Type 1 diabetes in high risk HLA genotype individuals (time to event) ( 29310926) Type 2 diabetes ( 25102180 31324766)	Body mass index ( 25673413) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494)
Interacting Genes		22 interacting genes: CAMK2G CDK11B CRABP1 CSNK2A1 DAAM2 HNRNPK MAPK1 MAPK3 MAPKAPK2 MDFI PIAS2 PRKACA PUF60 RBMY1A1 RPS6KA5 SNCA TSPYL4 TYSND1 UMAD1 YWHAB YWHAZ ZNF569	5 interacting genes: ANG CEBPA OGT RNASE1 SDCBP
Entrez ID		7054	6050
HPRD ID		01865	01412
Ensembl ID		ENSG00000180176	ENSG00000023191
Uniprot IDs		P07101 P78428	A0A140VJT8 P13489
PDB IDs		2XSN 4J6S 6ZN2 6ZVP 6ZZU 7A2G 7PIM	1A4Y 1Z7X 2BEX 2Q4G
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Protein Serine Kinase Activity Regulation Of Primary Metabolic Process Protein Serine/threonine Kinase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Sequestering Activity Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Protein Kinase Activity TORC1 Signaling Interleukin-34-mediated Signaling Pathway Kinase Activity Negative Regulation Of Macromolecule Metabolic Process TOR Signaling Regulation Of Golgi Inheritance Negative Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Protein Phosphorylation Regulation Of RNA Biosynthetic Process Negative Regulation Of Metabolic Process Insulin-like Growth Factor Receptor Signaling Pathway Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Regulation Of Protein Stability Phosphoserine Residue Binding Protein Domain Specific Binding Negative Regulation Of Catabolic Process Phosphorylation Regulation Of Multicellular Organismal Process Cardiac Neural Crest Cell Development Involved In Heart Development Trachea Formation Regulation Of Signal Transduction Phosphotyrosine Residue Binding Regulation Of Cell Communication Regulation Of Signaling Regulation Of MRNA Processing Focal Adhesion Outer Ear Morphogenesis ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Long-term Synaptic Potentiation Nucleus ERK1 And ERK2 Cascade Bergmann Glial Cell Differentiation Epidermal Growth Factor Receptor Signaling Pathway Cellular Response To Epinephrine Stimulus	Peptide Binding Hematopoietic Stem Cell Proliferation RNA Nuclease Activity Organelle Organization Negative Regulation Of RNA Metabolic Process Defense Response To Gram-positive Bacterium Endonuclease Activity Defense Response Regulation Of Phosphorus Metabolic Process Cell Communication Stem Cell Proliferation Response To Stress TRNA-specific Ribonuclease Activity Protein-containing Complex Organization Angiogenin-PRI Complex Nuclease Activity Macromolecule Biosynthetic Process Protein-containing Complex Assembly Animal Organ Development Cytoplasmic Translation Signaling Cellular Component Assembly Response To Hormone Cell Maturation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Chromatin DNA Binding CHOP-C/EBP Complex Regulation Of Ubiquitin-dependent Protein Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Nutrient Response To Vitamin B2 White Fat Cell Proliferation Memory C/EBP Complex Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Post-transcriptional Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Telomere Tethering At Nuclear Periphery Nuclear Pore Cytoplasmic Filaments Ribonuclease A Activity Ribonucleoside-diphosphate Reductase Complex Positive Regulation Of G0 To G1 Transition Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Purine Nucleotide Binding Ribonucleoside-diphosphate Reductase Activity Interleukin-5 Receptor Binding Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Interleukin-5 Receptor Complex Positive Regulation Of Extracellular Exosome Assembly Regulation Of Extracellular Exosome Assembly
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