TFF3 and SH3BGR

Data Source: HiPPIP (Novel)

		TFF3	SH3BGR
Name		trefoil factor 3	SH3 domain binding glutamate rich protein
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Secretory Granule	Nucleus Cytoplasm
	Molecular Function	Protein Binding Identical Protein Binding	Protein Binding SH3 Domain Binding
	Biological Process	Regulation Of Glucose Metabolic Process Maintenance Of Gastrointestinal Epithelium	None
Pathways		Estrogen-dependent gene expression	None
GWAS		Spatial memory ( 31596458 )	No GWAS studies recorded
Novel Interactors		2 novel interactors: SH3BGR TRAPPC10	5 novel interactors: PCNT PWP2 SLC19A1 SMAD7 TFF3
Interacting Genes		4 interacting genes: PCBD1 SGTA UBQLN2 ZSCAN9	2 interacting genes: CAPN1 FCHSD2
Entrez ID		7033	6450
HPRD ID		02797	03753
Ensembl ID		ENSG00000160180	ENSG00000185437
Uniprot IDs		Q07654	A0A804CBI3 C9JJT2 P55822
PDB IDs		1E9T 1PE3 6V1C	Not available
GO Terms Enriched among Interactors		Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress 4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity Tyrosine Biosynthetic Process Phenylalanine 4-monooxygenase Activity Tyrosine Biosynthetic Process, By Oxidation Of Phenylalanine TRC Complex Regulation Of Response To Endoplasmic Reticulum Stress ERAD Pathway Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Proteolysis Involved In Protein Catabolic Process BAT3 Complex Binding Negative Regulation Of Clathrin-dependent Endocytosis Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Tetrahydrobiopterin Biosynthetic Process Negative Regulation Of ERAD Pathway Response To Endoplasmic Reticulum Stress Tetrahydrobiopterin Metabolic Process Post-translational Protein Targeting To Endoplasmic Reticulum Membrane TRAPPII Protein Complex Pteridine-containing Compound Biosynthetic Process Tyrosine Metabolic Process Tail-anchored Membrane Protein Insertion Into ER Membrane TRAPP Complex Negative Regulation Of Receptor Internalization Early Endosome To Golgi Transport Regulation Of Clathrin-dependent Endocytosis Regulation Of Protein Catabolic Process Regulation Of Proteolysis	Beta-catenin Destruction Complex Disassembly Positive Regulation Of Chondrocyte Hypertrophy Methotrexate Transport Methotrexate Transmembrane Transporter Activity Folate:monoatomic Anion Antiporter Activity Stereocilium Shaft Positive Regulation Of Chondrocyte Development Folate Import Across Plasma Membrane 2',3'-cyclic GMP-AMP Binding Cyclic-GMP-AMP Transmembrane Transporter Activity