MLXIPL

Gene Name		MLX interacting protein-like
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Cytosol
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Factor Binding Carbohydrate Response Element Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Energy Reserve Metabolic Process Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cell Proliferation Anatomical Structure Morphogenesis Glucose Mediated Signaling Pathway Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Peptidyl-serine Phosphorylation Intracellular Signal Transduction Regulation Of Fatty Acid Biosynthetic Process Glucose Homeostasis Small Molecule Metabolic Process Positive Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Glycolytic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Lipid Biosynthetic Process Fatty Acid Homeostasis Triglyceride Homeostasis Negative Regulation Of Cell Cycle Arrest Cellular Response To Carbohydrate Stimulus Negative Regulation Of Oxidative Phosphorylation Regulation Of Energy Homeostasis
Pathways		PP2A-mediated dephosphorylation of key metabolic factors Integration of energy metabolism ChREBP activates metabolic gene expression PKA-mediated phosphorylation of key metabolic factors AMPK inhibits chREBP transcriptional activation activity
Drugs
Diseases
GWAS		HDL cholesterol ( 20686565) Hypertriglyceridemia ( 23505323 20657596) Lipid metabolism phenotypes ( 22286219) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Metabolic syndrome ( 22399527) Triglycerides ( 21909109 18193043 18193044 18193046 20864672 19060906 19060911 20686565) Urate levels ( 23263486)
Protein-protein Interactions		3 interactors: GRB2 MLX NIF3L1
Entrez ID		51085
HPRD ID		12033
Ensembl ID		ENSG00000009950
Uniprot IDs		Q9NP71
PDB IDs
Enriched GO Terms of Interacting Partners?		7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process Dihydrobiopterin Metabolic Process
Tagcloud ?		adipogenic adipokines calving cebpa cebpb chrebp crebbp dgat2 fo hydroxybutyrate lcfa lipogenesis lipogenic lpin1 med1 ncoa1 ncor2 nfkb1 nonesterified nrip1 parturition peripartal postpartal prepartal prepartum rxra scd sfat triacylglycerol