TAF7 and TAF4

Number of citations of the paper that reports this interaction (PubMedID 29111974)
76

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		TAF7	TAF4
Description		TATA-box binding protein associated factor 7	TATA-box binding protein associated factor 4
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GO Annotations	Cellular Component	Male Germ Cell Nucleus Nucleus Nucleoplasm Transcription Regulator Complex Transcription Factor TFIID Complex Cytoplasm Transcription Factor TFTC Complex MLL1 Complex	Chromatin Male Germ Cell Nucleus Nucleus Nucleoplasm Transcription Factor TFIID Complex Cytosol Protein-containing Complex Transcription Factor TFTC Complex MLL1 Complex
	Molecular Function	Transcription Cis-regulatory Region Binding TFIIH-class Transcription Factor Complex Binding Protein Binding RNA Polymerase II General Transcription Initiation Factor Activity Histone Acetyltransferase Binding Nuclear Vitamin D Receptor Binding Nuclear Thyroid Hormone Receptor Binding Protein Heterodimerization Activity Histone H3K27me3 Reader Activity P-TEFb Complex Binding DNA-binding Transcription Factor Binding	Core Promoter Sequence-specific DNA Binding DNA Binding Protein Binding RNA Polymerase II General Transcription Initiation Factor Activity Aryl Hydrocarbon Receptor Binding Protein Heterodimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Spermine Transport Regulation Of DNA Repair Chromatin Organization DNA-templated Transcription Initiation Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Negative Regulation Of Protein Kinase Activity Estrogen Receptor Signaling Pathway MRNA Transcription By RNA Polymerase II Negative Regulation Of MHC Class I Biosynthetic Process Negative Regulation Of MHC Class II Biosynthetic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II	Ovarian Follicle Development Regulation Of DNA Repair DNA-templated Transcription DNA-templated Transcription Initiation Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter MRNA Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II
Pathways		HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome RNA Polymerase II Pre-transcription Events Regulation of TP53 Activity through Phosphorylation RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance	HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome RNA Polymerase II Pre-transcription Events Regulation of TP53 Activity through Phosphorylation RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance
Drugs
Diseases
GWAS		Mean platelet volume ( 27863252 32888494) Refractive error ( 32231278)	Body mass index ( 28892062) Fasting glucose ( 33381925) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Red blood cell count ( 32888494) Response to fenofibrate (LDL cholesterol levels) ( 27002377)
Interacting Genes		28 interacting genes: AHR CDK7 CDK9 CPSF1 FAU GATA1 H3-4 HSF1 IKBKG MAP1LC3B OGT RBM6 SETD7 TAF1 TAF10 TAF11 TAF12 TAF15 TAF2 TAF4 TAF5 TAF6 TAF8 TAF9 TRIM22 TRIM24 YWHAE ZSCAN1	22 interacting genes: AHR ATF7 CBX3 CBX5 CREM GTF2A1 GTF2A2 H3-4 HTT JUN SP1 TAF1 TAF10 TAF11 TAF12 TAF2 TAF5 TAF6 TAF7 TAF8 TAF9 TCF12
Entrez ID		6879	6874
HPRD ID		07196	11797
Ensembl ID		ENSG00000178913	ENSG00000130699
Uniprot IDs		Q15545	O00268
PDB IDs		4RGW 5FUR 6MZL 6MZM 7EDX 7EG7 7EG8 7EG9 7EGA 7EGB 7EGC 7EGD 7EGE 7EGH 7EGI 7EGJ 7ENA 7ENC 8GXQ 8GXS 8WAK 8WAL 8WAN 8WAO 8WAP 8WAQ 8WAR 8WAS	1H3O 2P6V 6MZC 6MZD 6MZL 6MZM 7EDX 7EG7 7EG8 7EG9 7EGA 7EGB 7EGC 7EGD 7EGE 7EGF 7EGG 7EGI 7EGJ 7ENA 7ENC 8GXQ 8GXS 8WAK 8WAL 8WAN 8WAO 8WAP 8WAQ 8WAR 8WAS
Enriched GO Terms of Interacting Partners?		DNA-templated Transcription Initiation Transcription Initiation At RNA Polymerase II Promoter Transcription Factor TFIID Complex RNA Polymerase II General Transcription Initiation Factor Activity MRNA Transcription By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly MRNA Transcription Transcription Preinitiation Complex Assembly Transcription By RNA Polymerase II Positive Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of DNA-templated Transcription Initiation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Transcription Factor TFTC Complex DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Protein-DNA Complex Assembly Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Heterodimerization Activity Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA Repair RNA Metabolic Process MRNA Metabolic Process Nucleoplasm Positive Regulation Of Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Biosynthetic Process Regulation Of RNA Metabolic Process Nucleus Protein-containing Complex Organization Positive Regulation Of Macromolecule Metabolic Process Protein-containing Complex Assembly Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Response To Stress Positive Regulation Of Metabolic Process Nucleic Acid Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of DNA Metabolic Process Macromolecule Metabolic Process Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process SAGA Complex Regulation Of Primary Metabolic Process TBP-class Protein Binding	Transcription Factor TFIID Complex RNA Polymerase II General Transcription Initiation Factor Activity Positive Regulation Of DNA-templated Transcription Initiation RNA Polymerase II Preinitiation Complex Assembly Regulation Of DNA-templated Transcription Initiation Transcription Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of Transcription Initiation By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter DNA-templated Transcription Initiation MRNA Transcription By RNA Polymerase II Protein-DNA Complex Assembly MRNA Transcription Positive Regulation Of Transcription By RNA Polymerase II Transcription Factor TFTC Complex Transcription By RNA Polymerase II Protein Heterodimerization Activity Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process TBP-class Protein Binding Nucleoplasm Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Nucleobase-containing Compound Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Nucleus Protein-containing Complex Assembly Regulation Of Gene Expression Transcription Cis-regulatory Region Binding Regulation Of Macromolecule Biosynthetic Process MRNA Metabolic Process Regulation Of Primary Metabolic Process Protein-containing Complex Organization Macromolecule Biosynthetic Process Regulation Of Metabolic Process Regulation Of DNA Repair Regulation Of Macromolecule Metabolic Process SAGA Complex RNA Metabolic Process RNA Polymerase II General Transcription Initiation Factor Binding MLL1 Complex
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