SYPL1 and ARFGAP3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SYPL1	ARFGAP3
Description		synaptophysin like 1	ARF GTPase activating protein 3
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Synaptic Vesicle Membrane Secretory Granule Cytoplasmic Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Melanosome Extracellular Exosome	Golgi Membrane Cytoplasm Golgi Apparatus Cytosol Membrane
	Molecular Function	Protein Binding	GTPase Activator Activity Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Chemical Synaptic Transmission	Intracellular Protein Transport Protein Secretion Protein Transport Vesicle-mediated Transport COPI Coating Of Golgi Vesicle
Pathways			COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic CDC42 GTPase cycle RHOG GTPase cycle
Drugs
Diseases
GWAS			Resting metabolic rate ( 28476931)
Interacting Genes		11 interacting genes: ARFGAP3 CIB3 LMNA PBX3 PPIF RBFA SDCBP TARS2 TEX44 UBC VAMP2	10 interacting genes: APP CD14 CFTR CXCL8 LIME1 RTN4IP1 SMAD2 SNCA SYPL1 ZDHHC17
Entrez ID		6856	26286
HPRD ID		15459	06444
Ensembl ID		ENSG00000008282	ENSG00000242247
Uniprot IDs		A0A994J5J4 A0A994J846 A4D0R1 C9JYN0 Q16563	Q9NP61
PDB IDs			2CRW
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Release Of Cytochrome C From Mitochondria	Response To Interleukin-1 Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Calcium Ion Transmembrane Transport Regulation Of Presynapse Organization Regulation Of Monoatomic Ion Transport Regulation Of Long-term Neuronal Synaptic Plasticity Response To Growth Factor Positive Regulation Of Endocytosis Regulation Of Presynapse Assembly Regulation Of Monoatomic Ion Transmembrane Transport Endocytosis Myeloid Leukocyte Activation Regulation Of Neurotransmitter Uptake Regulation Of Cell Communication Cellular Response To Copper Ion Regulation Of Signaling Response To Lipid Golgi-associated Vesicle Membrane Amyloid Fibril Formation Microglial Cell Activation Receptor-mediated Endocytosis Cellular Response To Fibroblast Growth Factor Stimulus Cytoplasmic Vesicle Membrane Response To Copper Ion Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Vesicle-mediated Transport Leukocyte Activation Involved In Inflammatory Response Regulation Of Calcium Ion Transport Response To Fibroblast Growth Factor Import Into Cell Tau Protein Binding Amyloid-beta Complex Regulation Of Neuronal Synaptic Plasticity Growth Cone Lamellipodium Regulation Of Synapse Organization Regulation Of Response To Calcium Ion Regulation Of Signal Transduction Macrophage Activation Amylin Binding Positive Regulation Of Toll Signaling Pathway Cellular Response To Growth Factor Stimulus Cellular Response To CAMP Regulation Of Monoatomic Cation Transmembrane Transport Opsonin Receptor Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Response To Desipramine
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