SYPL1 and TARS2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SYPL1	TARS2
Description		synaptophysin like 1	threonyl-tRNA synthetase 2, mitochondrial
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Synaptic Vesicle Membrane Secretory Granule Cytoplasmic Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Melanosome Extracellular Exosome	Cytoplasm Mitochondrion Mitochondrial Matrix
	Molecular Function	Protein Binding	Nucleotide Binding Aminoacyl-tRNA Deacylase Activity Aminoacyl-tRNA Ligase Activity Threonine-tRNA Ligase Activity Protein Binding ATP Binding Ligase Activity Protein Homodimerization Activity
	Biological Process	Chemical Synaptic Transmission	Translation TRNA Aminoacylation For Protein Translation Threonyl-tRNA Aminoacylation TRNA Aminoacylation Mitochondrial Threonyl-tRNA Aminoacylation Aminoacyl-tRNA Metabolism Involved In Translational Fidelity
Pathways			Mitochondrial tRNA aminoacylation
Drugs			Threonine
Diseases
GWAS			Alanine aminotransferase levels ( 33547301) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronotype ( 27494321 30696823) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) LDL cholesterol levels ( 32203549) Liver enzyme levels (alanine transaminase) ( 33972514) Morning person ( 30696823) Morning vs. evening chronotype ( 27494321) Plateletcrit ( 32888494) Refractive error ( 32231278) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		11 interacting genes: ARFGAP3 CIB3 LMNA PBX3 PPIF RBFA SDCBP TARS2 TEX44 UBC VAMP2	9 interacting genes: ARL6IP1 ASB6 FKBP7 HOMEZ PLIN3 SLC17A9 SYPL1 TARS3 TNFRSF10D
Entrez ID		6856	80222
HPRD ID		15459	18148
Ensembl ID		ENSG00000008282	ENSG00000143374
Uniprot IDs		A0A994J5J4 A0A994J846 A4D0R1 C9JYN0 Q16563	Q9BW92 U3KQG0
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Release Of Cytochrome C From Mitochondria
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