STIM2 and STIM1

Number of citations of the paper that reports this interaction (PubMedID 11463338)
29

Data Source:
HPRD (in vivo, in vitro)

		STIM2	STIM1
Description		stromal interaction molecule 2	stromal interaction molecule 1
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytoskeleton Microtubule Plasma Membrane Membrane Sarcoplasmic Reticulum Cortical Endoplasmic Reticulum Sarcoplasmic Reticulum Membrane Plasma Membrane Raft
	Molecular Function	Calcium Channel Regulator Activity Calcium Ion Binding Protein Binding Store-operated Calcium Channel Activity Metal Ion Binding	Protease Binding Calcium Channel Regulator Activity Calcium Ion Binding Protein Binding Identical Protein Binding Metal Ion Binding Microtubule Plus-end Binding
	Biological Process	Store-operated Calcium Entry Monoatomic Ion Transport Calcium Ion Transport Intracellular Calcium Ion Homeostasis Activation Of Store-operated Calcium Channel Activity Positive Regulation Of Calcium Ion Transport Calcium Ion Transmembrane Transport	Store-operated Calcium Entry Detection Of Calcium Ion Monoatomic Ion Transport Calcium Ion Transport Intracellular Calcium Ion Homeostasis Activation Of Store-operated Calcium Channel Activity Positive Regulation Of Adenylate Cyclase Activity Positive Regulation Of Angiogenesis Regulation Of Calcium Ion Transport Enamel Mineralization Regulation Of Store-operated Calcium Entry
Pathways			Elevation of cytosolic Ca2+ levels Ion homeostasis Ion homeostasis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Diseases
GWAS		Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Carboplatin disposition in epthelial ovarian cancer ( 29367611) Chronotype ( 30696823) Diastolic blood pressure ( 30224653) General risk tolerance (MTAG) ( 30643258) Hirschsprung disease ( 25310821) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Photic sneeze reflex ( 27182965) Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid) ( 21829377) Refractive astigmatism ( 25367360) Smoking status (ever vs never smokers) ( 30643258) Superior frontal gyrus grey matter volume ( 25335168)	Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Calcium levels ( 29403010) Disruptive behavior disorder and attention deficit hyperactivity disorder ( 33495439) Hemoglobin ( 32888494) Malaria ( 31844061) Mean corpuscular volume ( 32888494) Mean platelet volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Platelet distribution width ( 27863252 32888494) Systemic lupus erythematosus ( 33272962) Waist circumference ( 34074324)
Interacting Genes		3 interacting genes: CALM1 PRPF40A STIM1	6 interacting genes: IFNGR1 INSIG2 RABAC1 SLC7A1 STIM2 TSPAN18
Entrez ID		57620	6786
HPRD ID		11609	05803
Ensembl ID		ENSG00000109689	ENSG00000167323
Uniprot IDs		B3KUB5 H0Y860 Q9P246	A0A8V8TMF0 A0A8V8TMG1 A0A8V8TNW0 A0A8V8TP73 E9PRZ7 G0XQ39 H0YDB2 Q13586
PDB IDs		2L5Y	2K60 2MAJ 2MAK 3TEQ 4O9B 6YEL
Enriched GO Terms of Interacting Partners?		Detection Of Calcium Ion Calcium Channel Regulator Activity Regulation Of Transmembrane Transporter Activity Regulation Of Cytokinesis Regulation Of Monoatomic Ion Transmembrane Transporter Activity Detection Of Chemical Stimulus Response To Calcium Ion Regulation Of Cell Division Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Calcium Ion Transport Mitochondrion-endoplasmic Reticulum Membrane Tethering Positive Regulation Of Sequestering Of Calcium Ion Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Monoatomic Ion Transmembrane Transport Transporter Inhibitor Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Calcium Ion Export Across Plasma Membrane Detection Of Stimulus Adenylate Cyclase Activator Activity Autophagosome Membrane Docking Regulation Of Metal Ion Transport Response To Metal Ion Regulation Of Monoatomic Cation Transmembrane Transport Activation Of Store-operated Calcium Channel Activity Positive Regulation Of Store-operated Calcium Channel Activity Negative Regulation Of Voltage-gated Calcium Channel Activity Cortical Endoplasmic Reticulum Regulation Of Monoatomic Ion Transport Store-operated Calcium Entry Enamel Mineralization Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Titin Binding Regulation Of Store-operated Calcium Entry Calcium Channel Inhibitor Activity Regulation Of Voltage-gated Calcium Channel Activity Regulation Of Cell Communication By Electrical Coupling MRNA Cis Splicing, Via Spliceosome Protein Phosphatase Activator Activity Tooth Mineralization Positive Regulation Of Adenylate Cyclase Activity U2-type Prespliceosome Calyx Of Held U1 SnRNP Positive Regulation Of Lyase Activity Calcium Ion Binding Microtubule Plus-end Binding Positive Regulation Of Cyclase Activity Catalytic Complex	Type II Interferon Receptor Activity Ribonucleoside-diphosphate Reductase Complex Positive Regulation Of G0 To G1 Transition Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Purine Nucleotide Binding Ribonucleoside-diphosphate Reductase Activity Ornithine Transport L-lysine Transmembrane Transporter Activity L-histidine Transmembrane Transporter Activity Lysine Transport L-ornithine Transmembrane Transport L-histidine Transmembrane Transport L-ornithine Transmembrane Transporter Activity L-arginine Import Across Plasma Membrane L-histidine Import Across Plasma Membrane Synaptic Vesicle Serotonin Biosynthetic Process Epinephrine Biosynthetic Process Epinephrine Metabolic Process Tyrosine 3-monooxygenase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Pteridine As One Donor, And Incorporation Of One Atom Of Oxygen Dopamine Biosynthetic Process From Tyrosine Negative Regulation Of SREBP Signaling Pathway SREBP-SCAP-Insig Complex SREBP-SCAP Complex Retention In Endoplasmic Reticulum Activation Of Store-operated Calcium Channel Activity L-lysine Transmembrane Transport Hyaloid Vascular Plexus Regression Positive Regulation Of Store-operated Calcium Channel Activity
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?