STIM2

Description		stromal interaction molecule 2
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane
	Molecular Function	Calcium Channel Regulator Activity Calcium Ion Binding Protein Binding Store-operated Calcium Channel Activity Metal Ion Binding
	Biological Process	Store-operated Calcium Entry Monoatomic Ion Transport Calcium Ion Transport Intracellular Calcium Ion Homeostasis Activation Of Store-operated Calcium Channel Activity Positive Regulation Of Calcium Ion Transport Calcium Ion Transmembrane Transport
Pathways
Drugs
Diseases
GWAS		Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Carboplatin disposition in epthelial ovarian cancer ( 29367611) Chronotype ( 30696823) Diastolic blood pressure ( 30224653) General risk tolerance (MTAG) ( 30643258) Hirschsprung disease ( 25310821) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Photic sneeze reflex ( 27182965) Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid) ( 21829377) Refractive astigmatism ( 25367360) Smoking status (ever vs never smokers) ( 30643258) Superior frontal gyrus grey matter volume ( 25335168)
Interacting Genes		3 interacting genes: CALM1 PRPF40A STIM1
Entrez ID		57620
HPRD ID		11609
Ensembl ID		ENSG00000109689
Uniprot IDs		B3KUB5 H0Y860 Q9P246
PDB IDs		2L5Y
Enriched GO Terms of Interacting Partners?		Detection Of Calcium Ion Calcium Channel Regulator Activity Regulation Of Transmembrane Transporter Activity Regulation Of Cytokinesis Regulation Of Monoatomic Ion Transmembrane Transporter Activity Detection Of Chemical Stimulus Response To Calcium Ion Regulation Of Cell Division Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Calcium Ion Transport Mitochondrion-endoplasmic Reticulum Membrane Tethering Positive Regulation Of Sequestering Of Calcium Ion Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Monoatomic Ion Transmembrane Transport Transporter Inhibitor Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Calcium Ion Export Across Plasma Membrane Detection Of Stimulus Adenylate Cyclase Activator Activity Autophagosome Membrane Docking Regulation Of Metal Ion Transport Response To Metal Ion Regulation Of Monoatomic Cation Transmembrane Transport Activation Of Store-operated Calcium Channel Activity Positive Regulation Of Store-operated Calcium Channel Activity Negative Regulation Of Voltage-gated Calcium Channel Activity Cortical Endoplasmic Reticulum Regulation Of Monoatomic Ion Transport Store-operated Calcium Entry Enamel Mineralization Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Titin Binding Regulation Of Store-operated Calcium Entry Calcium Channel Inhibitor Activity Regulation Of Voltage-gated Calcium Channel Activity Regulation Of Cell Communication By Electrical Coupling MRNA Cis Splicing, Via Spliceosome Protein Phosphatase Activator Activity Tooth Mineralization Positive Regulation Of Adenylate Cyclase Activity U2-type Prespliceosome Calyx Of Held U1 SnRNP Positive Regulation Of Lyase Activity Calcium Ion Binding Microtubule Plus-end Binding Positive Regulation Of Cyclase Activity Catalytic Complex
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