ARHGAP35

Name	Rho GTPase activating protein 35
Structure
Interactors	6 interactors: CDC42 GRB2 KRT31 PTPRZ1 RAC1 SRC
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Actin Cytoskeleton Membrane Ciliary Basal Body Cell Projection
	Molecular Function	Nucleotide Binding DNA Binding GTPase Activity GTPase Activator Activity GTP Binding Phospholipid Binding Lipid Binding
	Biological Process	Neural Tube Closure Signal Transduction Rho Protein Signal Transduction Axon Guidance Axonal Fasciculation Regulation Of Actin Polymerization Or Depolymerization Regulation Of Cell Shape Regulation Of Cell Size Positive Regulation Of Neuron Projection Development Cell Migration Central Nervous System Neuron Axonogenesis Mammary Gland Development Forebrain Development Establishment Or Maintenance Of Actin Cytoskeleton Polarity Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Rho Protein Signal Transduction Camera-type Eye Development Negative Regulation Of Vascular Permeability Wound Healing, Spreading Of Cells Positive Regulation Of Cilium Assembly Regulation Of Axonogenesis Regulation Of Small GTPase Mediated Signal Transduction Neuron Projection Guidance
Pathways	Sema4D mediated inhibition of cell attachment and migration PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOQ GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle RND3 GTPase cycle RND2 GTPase cycle RND1 GTPase cycle
GWAS	Aspartate aminotransferase levels ( 33339817 ) Brain morphology (MOSTest) ( 32665545 ) Deep white matter hyperintensities ( 32517579 )
Entrez ID	2909
HPRD ID	05592
Ensembl ID	ENSG00000160007
Uniprot IDs	Q9NRY4
PDB IDs	2K85 3C5H 3FK2 6PXC 6WAY 8DGQ
GO Terms Enriched among Interactors ?	Positive Regulation Of Lamellipodium Organization Regulation Of Lamellipodium Organization Anatomical Structure Morphogenesis G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Actin Cytoskeleton Organization Thioesterase Binding Actin Filament-based Process Cytoskeleton Organization Regulation Of Protein-containing Complex Assembly Cell Differentiation Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Cell Adhesion Positive Regulation Of Organelle Organization Supramolecular Fiber Organization Positive Regulation Of Supramolecular Fiber Organization Angiotensin-activated Signaling Pathway GTP-dependent Protein Binding Cellular Developmental Process Positive Regulation Of Cytoskeleton Organization Cell-cell Junction Regulation Of MAPK Cascade Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell-substrate Adhesion Ephrin Receptor Binding Phagocytosis, Engulfment Regulation Of Cell Projection Assembly Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Cell Adhesion Regulation Of Actin Filament Organization Actin Filament Organization Small GTPase-mediated Signal Transduction Regulation Of Lamellipodium Assembly Neuron Projection Morphogenesis Cell Projection Morphogenesis Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Membrane Invagination T Cell Costimulation Substrate Adhesion-dependent Cell Spreading Regulation Of Endocytosis Positive Regulation Of Actin Filament Polymerization Non-canonical Wnt Signaling Pathway Positive Regulation Of Stress Fiber Assembly Extracellular Exosome Morphogenesis Of An Epithelium Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Cell Projection Organization Regulation Of Substrate Adhesion-dependent Cell Spreading