SPAG4 and CSGALNACT1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SPAG4	CSGALNACT1
Description		sperm associated antigen 4	chondroitin sulfate N-acetylgalactosaminyltransferase 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nuclear Inner Membrane Cytoplasm Cytoskeleton Cilium Membrane Motile Cilium Meiotic Nuclear Membrane Microtubule Tethering Complex Cell Projection	Golgi Membrane Golgi Apparatus Membrane Golgi Cisterna Membrane
	Molecular Function	Structural Molecule Activity Protein Binding Protein-membrane Adaptor Activity	Protein Binding Acetylgalactosaminyltransferase Activity Peptidoglycan Glycosyltransferase Activity Glucuronosyltransferase Activity Transferase Activity Metal Ion Binding Glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase Activity Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase Activity
	Biological Process	Spermatogenesis Cell Differentiation	Endochondral Ossification Heparan Sulfate Proteoglycan Biosynthetic Process UDP-N-acetylgalactosamine Metabolic Process Proteoglycan Biosynthetic Process Extracellular Matrix Organization Heparin Proteoglycan Biosynthetic Process UDP-glucuronate Metabolic Process Chondroitin Sulfate Proteoglycan Biosynthetic Process Dermatan Sulfate Proteoglycan Biosynthetic Process Chondroitin Sulfate Proteoglycan Metabolic Process Cartilage Development
Pathways			CS-GAG biosynthesis
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Refractive error ( 32231278) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Appendicular lean mass ( 33097823) Glucocorticoid-induced osteonecrosis (age 10 years and older) ( 26265699) Height ( 31562340) Language performance in older adults (adjusted for episodic memory) ( 28577822) Low density lipoprotein cholesterol levels ( 32154731) Lung function in never smokers (low FEV1 vs average FEV1) ( 26423011) Oropharynx cancer ( 27749845) Persistent hepatitis B virus infection ( 27244555) Response to antidepressant treatment (citalopram) ( 23726668) Response to antidepressants (symptom improvement) ( 29160301) Triglyceride levels ( 32154731) Venous thromboembolism ( 33592630)
Interacting Genes		24 interacting genes: ABHD16A ASGR1 BMP10 CSGALNACT1 ERMP1 GOSR2 IGFBP5 MS4A13 NRM ODF1 PAXIP1 PGA4 PLN PTPN9 RUSF1 SCAMP4 SCD SEC22A SUN5 TMEM187 TMEM60 TNMD TRARG1 TSPO2	1 interacting genes: SPAG4
Entrez ID		6676	55790
HPRD ID		04330	13114
Ensembl ID		ENSG00000061656	ENSG00000147408
Uniprot IDs		A0A7P0Z4G5 Q9NPE6	Q8TDX6
PDB IDs
Enriched GO Terms of Interacting Partners?			Meiotic Nuclear Membrane Microtubule Tethering Complex Positive Regulation Of Neurotransmitter Secretion Anterograde Synaptic Vesicle Transport Positive Regulation Of Glutamate Neurotransmitter Secretion In Response To Membrane Depolarization Platelet Dense Granule Organization Melanosome Membrane Regulation Of Dopamine Secretion Regulation Of Dopamine Receptor Signaling Pathway Asymmetric Synapse Regulation Of Glutamate Secretion Negative Regulation Of Dendritic Spine Morphogenesis Regulation Of Glutamate Secretion, Neurotransmission Positive Regulation Of Glutamate Secretion Sarcoplasm Positive Regulation Of Amino Acid Transport Positive Regulation Of Glutamate Secretion, Neurotransmission BLOC-1 Complex Negative Regulation Of Dendritic Spine Development Positive Regulation Of Receptor Internalization Protein-membrane Adaptor Activity Regulation Of Catecholamine Secretion Vesicle Transport Along Microtubule Synaptic Vesicle Transport Positive Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Dendritic Spine Morphogenesis Hippocampal Mossy Fiber To CA3 Synapse Anterograde Axonal Transport Melanosome Organization Pigment Granule Organization Nuclear Inner Membrane Dendrite Morphogenesis Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Receptor-mediated Endocytosis Regulation Of Dendritic Spine Development Vesicle Cytoskeletal Trafficking Axon Cytoplasm Axonal Transport Secretory Granule Organization Protein Transmembrane Transport Regulation Of Receptor Internalization Retina Development In Camera-type Eye Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Amine Transport Axo-dendritic Transport Regulation Of Neurotransmitter Secretion Organelle Transport Along Microtubule Schaffer Collateral - CA1 Synapse Coagulation Blood Coagulation Establishment Of Vesicle Localization
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