SPAG4 and SUN5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SPAG4	SUN5
Description		sperm associated antigen 4	Sad1 and UNC84 domain containing 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nuclear Inner Membrane Cytoplasm Cytoskeleton Cilium Membrane Motile Cilium Meiotic Nuclear Membrane Microtubule Tethering Complex Cell Projection	Nucleus Nuclear Envelope Nuclear Inner Membrane Golgi Apparatus Membrane Meiotic Nuclear Membrane Microtubule Tethering Complex Sperm Head-tail Coupling Apparatus
	Molecular Function	Structural Molecule Activity Protein Binding Protein-membrane Adaptor Activity	Protein Binding Protein-membrane Adaptor Activity
	Biological Process	Spermatogenesis Cell Differentiation	Spermatogenesis Spermatid Development Cell Differentiation
Pathways
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Refractive error ( 32231278) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		24 interacting genes: ABHD16A ASGR1 BMP10 CSGALNACT1 ERMP1 GOSR2 IGFBP5 MS4A13 NRM ODF1 PAXIP1 PGA4 PLN PTPN9 RUSF1 SCAMP4 SCD SEC22A SUN5 TMEM187 TMEM60 TNMD TRARG1 TSPO2	3 interacting genes: APP SPAG4 UBC
Entrez ID		6676	140732
HPRD ID		04330	15422
Ensembl ID		ENSG00000061656	ENSG00000167098
Uniprot IDs		A0A7P0Z4G5 Q9NPE6	A0A384MDU5 A9Z1W8 Q8TC36
PDB IDs
Enriched GO Terms of Interacting Partners?			Collateral Sprouting Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Developmental Cell Growth Microglia Development Developmental Growth Involved In Morphogenesis Positive Regulation Of G Protein-coupled Receptor Internalization Axonogenesis Centrosome-templated Microtubule Nucleation Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Microtubule Nucleation By Microtubule Organizing Center Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Neuron Projection Morphogenesis Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Corticospinal Tract Morphogenesis Corpus Callosum Morphogenesis Cell Projection Morphogenesis Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity Ciliary Transition Fiber Peptidase Activator Activity Cellular Response To Manganese Ion Centriolar Subdistal Appendage Meiotic Nuclear Membrane Microtubule Tethering Complex Antifungal Humoral Response
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