UAP1 and DEDD

		UAP1	DEDD
Description		UDP-N-acetylglucosamine pyrophosphorylase 1	death effector domain containing
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane	Nucleus Nucleolus Cytoplasm
	Molecular Function	UDP-N-acetylglucosamine Diphosphorylase Activity Transferase Activity Transferase Activity, Transferring Phosphorus-containing Groups Nucleotidyltransferase Activity Identical Protein Binding UDP-N-acetylgalactosamine Diphosphorylase Activity Uridylyltransferase Activity Protein Serine Pyrophosphorylase Activity	DNA Binding Protein Binding
	Biological Process	Immune System Process UDP-N-acetylglucosamine Biosynthetic Process Positive Regulation Of Type I Interferon Production Innate Immune Response Antiviral Innate Immune Response	Developmental Process Involved In Reproduction Apoptotic Process Spermatogenesis Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Protein Catabolic Process Regulation Of Apoptotic Process Decidualization Negative Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I
Pathways		Synthesis of UDP-N-acetyl-glucosamine
Drugs		Uridine-Diphosphate-N-Acetylgalactosamine Uridine-Diphosphate-N-Acetylglucosamine
Diseases
GWAS
Interacting Genes		1 interacting genes: FBXL17	16 interacting genes: APLP2 APP BATF2 CASP10 CASP3 CASP8 CFLAR DEDD2 FADD GTF3C1 GTF3C3 HOXD4 KRT18 KRT8 SHMT1 SMAD3
Entrez ID		6675	9191
HPRD ID		04178	06022
Ensembl ID		ENSG00000117143	ENSG00000158796
Uniprot IDs		A0A140VKC0 Q16222	B1AQP5 O75618
PDB IDs		1JV1 1JV3 1JVD 1JVG 6Z2F 8QH2
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Glycine Import Across Plasma Membrane Negative Regulation Of Dopamine Receptor Signaling Pathway Dorsal Root Ganglion Development Negative Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Negative Regulation Of Striated Muscle Cell Differentiation Negative Regulation Of Amino Acid Transport Response To Cocaine Positive Regulation Of Excitatory Postsynaptic Potential Tissue Development Ganglion Development G-protein Alpha-subunit Binding Negative Regulation Of Muscle Hypertrophy Response To Amphetamine Regulation Of Dopamine Receptor Signaling Pathway Negative Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Potassium Ion Transport Negative Regulation Of Organ Growth Positive Regulation Of Heart Contraction Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Positive Regulation Of Heart Rate Negative Regulation Of Cardiac Muscle Tissue Growth Response To Amine Negative Regulation Of Cardiac Muscle Hypertrophy Decidualization Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Transcription By RNA Polymerase I Negative Regulation Of Transcription By RNA Polymerase I Neural Crest Cell Differentiation Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Modulation Of Excitatory Postsynaptic Potential Negative Regulation Of G Protein-coupled Receptor Signaling Pathway	Ripoptosome CD95 Death-inducing Signaling Complex Death-inducing Signaling Complex Extrinsic Apoptotic Signaling Pathway Death Receptor Binding Apoptotic Signaling Pathway Death Effector Domain Binding Positive Regulation Of Neuron Apoptotic Process Apoptotic Process Programmed Cell Death Cell Death Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Cysteine-type Endopeptidase Activity Positive Regulation Of Execution Phase Of Apoptosis Execution Phase Of Apoptosis Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Necroptotic Process Regulation Of Programmed Necrotic Cell Death Regulation Of Neuron Apoptotic Process Response To Anesthetic Transcription Factor TFIIIC Complex 5S Class RRNA Transcription By RNA Polymerase III Cysteine-type Peptidase Activity Response To External Biotic Stimulus Epithelial Cell Apoptotic Process Positive Regulation Of Pyroptotic Inflammatory Response TRAIL-activated Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Process Response To Cobalt Ion Positive Regulation Of Interleukin-1 Beta Production Regulation Of Programmed Cell Death TRNA Transcription By RNA Polymerase III TRNA Transcription RNA Polymerase III General Transcription Initiation Factor Activity Scaffold Protein Binding Positive Regulation Of Interleukin-1 Production Cell Surface Receptor Signaling Pathway Cell Body Positive Regulation Of Macrophage Differentiation Hepatocyte Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction DNA Binding Transition Metal Ion Binding Platelet Alpha Granule Negative Regulation Of Necroptotic Process Regulation Of Interleukin-1 Beta Production Myeloid Cell Differentiation
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