CASTOR1 and PSMD5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CASTOR1	PSMD5
Description		cytosolic arginine sensor for mTORC1 subunit 1	proteasome 26S subunit, non-ATPase 5
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol GATOR2 Complex	Proteasome Complex Cytosol Proteasome Regulatory Particle, Base Subcomplex Proteasome Accessory Complex
	Molecular Function	Protein Binding Arginine Binding Identical Protein Binding Molecular Sensor Activity Protein Sequestering Activity	Protein Binding
	Biological Process	Cellular Response To Nutrient Levels Cellular Response To Amino Acid Starvation Protein K6-linked Ubiquitination Cellular Response To L-arginine Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling	Proteasome Assembly Proteasome Regulatory Particle Assembly
Pathways		Amino acids regulate mTORC1	Proteasome assembly Proteasome assembly
Drugs
Diseases
GWAS		Coronary artery disease ( 33020668) Myocardial infarction ( 33532862)	Hip circumference adjusted for BMI ( 34021172) Systolic blood pressure ( 27618452)
Interacting Genes		5 interacting genes: AKT1 CASTOR2 PSMD5 TMA16 ZC2HC1B	11 interacting genes: APP BTBD1 BTBD2 CASTOR1 FILNC1 LCOR LNX2 PSMC1 PSMC2 PSMD2 TFCP2
Entrez ID		652968	5711
HPRD ID		18904	05121
Ensembl ID		ENSG00000239282	ENSG00000095261
Uniprot IDs		Q8WTX7	Q16401
PDB IDs		5GS9 5GT7 5GT8 5GV2 5I2C
Enriched GO Terms of Interacting Partners?		Response To Rapamycin Positive Regulation Of Protein Localization To Endoplasmic Reticulum Nitric-oxide Synthase Regulator Activity Negative Regulation Of TOR Signaling Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Negative Regulation Of SREBP Signaling Pathway Response To Insulin-like Growth Factor Stimulus Negative Regulation Of Fatty Acid Beta-oxidation Positive Regulation Of TORC2 Signaling TRNA Stabilization Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide Potassium Channel Activator Activity Negative Regulation Of TORC1 Signaling Mammalian Oogenesis Stage RNA (guanine-N7)-methylation Regulation Of TORC1 Signaling Negative Regulation Of Fatty Acid Transport Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Cellular Response To Peptide Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Regulation Of TOR Signaling Maintenance Of Protein Location In Mitochondrion TRNA (guanine-N7)-methylation Activation-induced Cell Death Of T Cells Regulation Of Long-chain Fatty Acid Import Into Cell TORC2 Complex Binding Cellular Response To Rapamycin Peripheral Nervous System Myelin Maintenance Regulation Of Endodeoxyribonuclease Activity Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Deoxyribonuclease Activity Negative Regulation Of Protein Localization To Lysosome Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Regulation Of TRNA Methylation Positive Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Endodeoxyribonuclease Activity SREBP-SCAP Complex Retention In Endoplasmic Reticulum Proteasome Regulatory Particle Assembly Preribosome Binding Cellular Response To L-arginine Arginine Binding Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Maternal Placenta Development Regulation Of SREBP Signaling Pathway GATOR2 Complex Maintenance Of Protein Localization In Endoplasmic Reticulum Anoikis PERK-mediated Unfolded Protein Response Negative Regulation Of PERK-mediated Unfolded Protein Response	Proteasome Regulatory Particle, Base Subcomplex Proteasome Accessory Complex Proteasome-activating Activity Proteasome Complex Proteasome Regulatory Particle P-body Regulation Of Protein Catabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Proteolysis Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cytoplasmic Ribonucleoprotein Granule Proteasome Storage Granule Molecular Sensor Activity Cellular Response To L-arginine Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Positive Regulation Of Proteasomal Protein Catabolic Process Secretory Granule Lumen Neurogenesis Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Ficolin-1-rich Granule Lumen Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway
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