CASTOR1 and TMA16

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CASTOR1	TMA16
Description		cytosolic arginine sensor for mTORC1 subunit 1	translation machinery associated 16 homolog
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GO Annotations	Cellular Component	Cytoplasm Cytosol GATOR2 Complex	Nucleus Nucleoplasm Nucleolus
	Molecular Function	Protein Binding Arginine Binding Identical Protein Binding Molecular Sensor Activity Protein Sequestering Activity	Protein Binding Preribosome Binding
	Biological Process	Cellular Response To Nutrient Levels Cellular Response To Amino Acid Starvation Protein K6-linked Ubiquitination Cellular Response To L-arginine Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling	Ribosome Biogenesis Ribosomal Large Subunit Biogenesis
Pathways		Amino acids regulate mTORC1
Drugs
Diseases
GWAS		Coronary artery disease ( 33020668) Myocardial infarction ( 33532862)	Small cell lung carcinoma ( 28604730)
Interacting Genes		5 interacting genes: AKT1 CASTOR2 PSMD5 TMA16 ZC2HC1B	9 interacting genes: AP2M1 APP CASTOR1 CEBPA IKBKG KLHL2 KRTAP10-7 NEDD4L TSPYL2
Entrez ID		652968	55319
HPRD ID		18904	07739
Ensembl ID		ENSG00000239282	ENSG00000198498
Uniprot IDs		Q8WTX7	Q96EY4
PDB IDs		5GS9 5GT7 5GT8 5GV2 5I2C	6LSS 6LU8 8FLA 8FLB 8FLC 8IDT 8IDY 8INE 8INF
Enriched GO Terms of Interacting Partners?		Response To Rapamycin Positive Regulation Of Protein Localization To Endoplasmic Reticulum Nitric-oxide Synthase Regulator Activity Negative Regulation Of TOR Signaling Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Negative Regulation Of SREBP Signaling Pathway Response To Insulin-like Growth Factor Stimulus Negative Regulation Of Fatty Acid Beta-oxidation Positive Regulation Of TORC2 Signaling TRNA Stabilization Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide Potassium Channel Activator Activity Negative Regulation Of TORC1 Signaling Mammalian Oogenesis Stage RNA (guanine-N7)-methylation Regulation Of TORC1 Signaling Negative Regulation Of Fatty Acid Transport Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Cellular Response To Peptide Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Regulation Of TOR Signaling Maintenance Of Protein Location In Mitochondrion TRNA (guanine-N7)-methylation Activation-induced Cell Death Of T Cells Regulation Of Long-chain Fatty Acid Import Into Cell TORC2 Complex Binding Cellular Response To Rapamycin Peripheral Nervous System Myelin Maintenance Regulation Of Endodeoxyribonuclease Activity Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Deoxyribonuclease Activity Negative Regulation Of Protein Localization To Lysosome Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Regulation Of TRNA Methylation Positive Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Endodeoxyribonuclease Activity SREBP-SCAP Complex Retention In Endoplasmic Reticulum Proteasome Regulatory Particle Assembly Preribosome Binding Cellular Response To L-arginine Arginine Binding Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Maternal Placenta Development Regulation Of SREBP Signaling Pathway GATOR2 Complex Maintenance Of Protein Localization In Endoplasmic Reticulum Anoikis PERK-mediated Unfolded Protein Response Negative Regulation Of PERK-mediated Unfolded Protein Response	Positive Regulation Of Proteolysis Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Catabolic Process Low-density Lipoprotein Particle Receptor Binding Positive Regulation Of Protein Catabolic Process Negative Regulation Of Protein Localization Positive Regulation Of Endocytosis Positive Regulation Of Receptor Internalization Identical Protein Binding Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Positive Regulation Of Protein Metabolic Process Regulation Of Response To Calcium Ion Amylin Binding Regulation Of Proteolysis Endosome To Plasma Membrane Transport Vesicle Regulation Of Protein Metabolic Process Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Receptor-mediated Endocytosis Clathrin-coated Pit Regulation Of Protein Catabolic Process Protein Heterodimerization Activity Lipoprotein Particle Regulation Of Receptor Internalization Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Regulation Of Endocytosis CHOP-C/EBP Complex Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Vitamin B2 C/EBP Complex Receptor Internalization Linear Polyubiquitin Binding Negative Regulation Of Sodium Ion Import Across Plasma Membrane Molecular Sensor Activity Cellular Response To L-arginine Endocytosis Notch Signaling Pathway Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
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