CASTOR1 and ZC2HC1B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CASTOR1	ZC2HC1B
Description		cytosolic arginine sensor for mTORC1 subunit 1	zinc finger C2HC-type containing 1B
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol GATOR2 Complex
	Molecular Function	Protein Binding Arginine Binding Identical Protein Binding Molecular Sensor Activity Protein Sequestering Activity	Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Cellular Response To Nutrient Levels Cellular Response To Amino Acid Starvation Protein K6-linked Ubiquitination Cellular Response To L-arginine Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling
Pathways		Amino acids regulate mTORC1
Drugs
Diseases
GWAS		Coronary artery disease ( 33020668) Myocardial infarction ( 33532862)	Diffusing capacity of carbon monoxide ( 30694715)
Interacting Genes		5 interacting genes: AKT1 CASTOR2 PSMD5 TMA16 ZC2HC1B	6 interacting genes: CASTOR1 CFTR GABPA NCK2 NFKBID ZGPAT
Entrez ID		652968	153918
HPRD ID		18904	10178
Ensembl ID		ENSG00000239282	ENSG00000118491
Uniprot IDs		Q8WTX7	Q5TFG8
PDB IDs		5GS9 5GT7 5GT8 5GV2 5I2C
Enriched GO Terms of Interacting Partners?		Response To Rapamycin Positive Regulation Of Protein Localization To Endoplasmic Reticulum Nitric-oxide Synthase Regulator Activity Negative Regulation Of TOR Signaling Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Negative Regulation Of SREBP Signaling Pathway Response To Insulin-like Growth Factor Stimulus Negative Regulation Of Fatty Acid Beta-oxidation Positive Regulation Of TORC2 Signaling TRNA Stabilization Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide Potassium Channel Activator Activity Negative Regulation Of TORC1 Signaling Mammalian Oogenesis Stage RNA (guanine-N7)-methylation Regulation Of TORC1 Signaling Negative Regulation Of Fatty Acid Transport Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Cellular Response To Peptide Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Regulation Of TOR Signaling Maintenance Of Protein Location In Mitochondrion TRNA (guanine-N7)-methylation Activation-induced Cell Death Of T Cells Regulation Of Long-chain Fatty Acid Import Into Cell TORC2 Complex Binding Cellular Response To Rapamycin Peripheral Nervous System Myelin Maintenance Regulation Of Endodeoxyribonuclease Activity Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Deoxyribonuclease Activity Negative Regulation Of Protein Localization To Lysosome Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Regulation Of TRNA Methylation Positive Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Endodeoxyribonuclease Activity SREBP-SCAP Complex Retention In Endoplasmic Reticulum Proteasome Regulatory Particle Assembly Preribosome Binding Cellular Response To L-arginine Arginine Binding Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Maternal Placenta Development Regulation Of SREBP Signaling Pathway GATOR2 Complex Maintenance Of Protein Localization In Endoplasmic Reticulum Anoikis PERK-mediated Unfolded Protein Response Negative Regulation Of PERK-mediated Unfolded Protein Response	Positive Regulation Of Anion Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Monoatomic Anion Transport Molecular Sensor Activity Cellular Response To L-arginine Bicarbonate Transmembrane Transporter Activity Response To Endoplasmic Reticulum Stress Intracellular PH Elevation Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Positive Regulation Of Enamel Mineralization Transepithelial Water Transport Amelogenesis Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress Signal Complex Assembly Regulation Of Translation In Response To Endoplasmic Reticulum Stress Positive Regulation Of T Cell Activation Regulation Of Translational Initiation In Response To Stress Positive Regulation Of Translation In Response To Stress Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity GATOR2 Complex Arginine Binding
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