PSMD5 and PSMC1

Number of citations of the paper that reports this interaction (PubMedID 10625621)
0

Data Source:
HPRD (in vitro)

		PSMD5	PSMC1
Description		proteasome 26S subunit, non-ATPase 5	proteasome 26S subunit, ATPase 1
Image		No pdb structure
GO Annotations	Cellular Component	Proteasome Complex Cytosol Proteasome Regulatory Particle, Base Subcomplex Proteasome Accessory Complex	Proteasome Complex Nucleus Nucleoplasm Cytoplasm Cytosol Proteasome Regulatory Particle Proteasome Regulatory Particle, Base Subcomplex Membrane Proteasome Accessory Complex
	Molecular Function	Protein Binding	Nucleotide Binding RNA Binding Protein Binding ATP Binding ATP Hydrolysis Activity Proteasome-activating Activity
	Biological Process	Proteasome Assembly Proteasome Regulatory Particle Assembly	Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process
Pathways		Proteasome assembly Proteasome assembly	Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL N-glycan trimming in the ER and Calnexin/Calreticulin cycle Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases Assembly of the pre-replicative complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling KEAP1-NFE2L2 pathway GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 Degradation of CDH1 Somitogenesis Antigen processing: Ubiquitination & Proteasome degradation Proteasome assembly Proteasome assembly GSK3B-mediated proteasomal degradation of PD-L1(CD274) SPOP-mediated proteasomal degradation of PD-L1(CD274) AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) Degradation of CRY and PER proteins Degradation of CRY and PER proteins Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Drugs
Diseases
GWAS		Hip circumference adjusted for BMI ( 34021172) Systolic blood pressure ( 27618452)	Response to platinum-based neoadjuvant chemotherapy in cervical cancer ( 28120872) Seasonality and depression ( 30217971)
Interacting Genes		11 interacting genes: APP BTBD1 BTBD2 CASTOR1 FILNC1 LCOR LNX2 PSMC1 PSMC2 PSMD2 TFCP2	39 interacting genes: APP ATXN7 CCDC85B CCND3 CEBPA CNOT7 CRK DSCR9 FKBP8 HSPB1 JMJD1C JMJD6 KDM1A LINC01554 LNX1 MAGEA2 MAGEA2B MEOX2 MORF4L1 OGT PAAF1 PAX4 PIAS3 PRKN PSMA7 PSMC2 PSMD2 PSMD5 PSMD7 PTGER4 STMN2 SUMO2 SUV39H1 TRAF6 UBASH3A UBLCP1 VCP VHL ZBTB8A
Entrez ID		5711	5700
HPRD ID		05121	04084
Ensembl ID		ENSG00000095261	ENSG00000100764
Uniprot IDs		Q16401	P62191 Q53XL8
PDB IDs			5GJQ 5GJR 5L4G 5LN3 5M32 5T0C 5T0G 5T0H 5T0I 5T0J 5VFP 5VFQ 5VFR 5VFS 5VFT 5VFU 5VGZ 5VHF 5VHH 5VHI 5VHJ 5VHM 5VHN 5VHO 5VHP 5VHQ 5VHR 5VHS 6MSB 6MSD 6MSG 6MSH 6MSJ 6MSK 6WJD 6WJN 7QXN 7QXP 7QXU 7QXW 7QXX 7QY7 7QYA 7QYB 7W37 7W38 7W39 7W3A 7W3B 7W3C 7W3F 7W3G 7W3H 7W3I 7W3J 7W3K 7W3M 8CVT 8JRI 8JRT 8JTI 8K0G 8USB 8USC 8USD 9E8G 9E8H 9E8I 9E8J 9E8K 9E8L 9E8N 9E8O 9E8Q
Enriched GO Terms of Interacting Partners?		Proteasome Regulatory Particle, Base Subcomplex Proteasome Accessory Complex Proteasome-activating Activity Proteasome Complex Proteasome Regulatory Particle P-body Regulation Of Protein Catabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Proteolysis Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cytoplasmic Ribonucleoprotein Granule Proteasome Storage Granule Molecular Sensor Activity Cellular Response To L-arginine Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Positive Regulation Of Proteasomal Protein Catabolic Process Secretory Granule Lumen Neurogenesis Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Ficolin-1-rich Granule Lumen Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway	Proteasome Complex Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Post-translational Protein Modification Regulation Of Gene Expression Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Regulation Of Post-translational Protein Modification Regulation Of Protein Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Protein Modification Process Positive Regulation Of Protein Metabolic Process Nucleus Positive Regulation Of Proteolysis Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Protein Sumoylation Regulation Of Protein Catabolic Process Proteasome Regulatory Particle, Base Subcomplex Negative Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Binding Negative Regulation Of Biosynthetic Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Proteasome Accessory Complex Positive Regulation Of Protein Catabolic Process Protein Catabolic Process Histone Deacetylase Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Metabolic Process Macromolecule Catabolic Process Regulation Of Protein Sumoylation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Proteolysis
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?