SLC5A5 and KRTAP3-1

Number of citations of the paper that reports this interaction (PubMedID 36949045)
82

Data Source:
BioGRID (two hybrid)

		SLC5A5	KRTAP3-1
Description		solute carrier family 5 member 5	keratin associated protein 3-1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Membrane Extracellular Exosome Extracellular Vesicle	Cytosol Intermediate Filament Keratin Filament
	Molecular Function	Protein Binding Sodium:iodide Symporter Activity Iodide Transmembrane Transporter Activity Symporter Activity Solute:sodium Symporter Activity Monoatomic Anion:sodium Symporter Activity Transmembrane Transporter Activity Protein Homodimerization Activity Metal Ion Binding	Structural Molecule Activity Protein Binding
	Biological Process	Thyroid Hormone Generation Monoatomic Ion Transport Sodium Ion Transport Iodide Transport Sodium Ion Transmembrane Transport Transmembrane Transport Cellular Response To CAMP Cellular Response To Gonadotropin Stimulus Transport Across Blood-brain Barrier Iodide Transmembrane Transport Cellular Response To Forskolin Cellular Response To Thyroid Stimulating Hormone
Pathways		Thyroxine biosynthesis Defective SLC5A5 causes thyroid dyshormonogenesis 1 (TDH1) SLC-mediated transport of inorganic anions	Keratinization
Drugs		Iodine Potassium perchlorate
Diseases		Thyroid dyshormonogenesis; Dyshormogenetic goiter
GWAS		Diastolic blood pressure ( 29208002)
Interacting Genes		6 interacting genes: CYSRT1 ERBIN KRTAP1-3 KRTAP3-1 NBPF19 NOTCH2NLA	83 interacting genes: ADAM12 AGXT ANAPC11 BMP7 CDKN1A CELA2B CERK CFP CIMIP1 CNNM3 CREB5 CTRC CYSRT1 DMRT3 DOCK2 FAM168A FAM222B FOXH1 FRS3 GATA2 GNE GPS2 GSTP1 HCK HEY2 HOXB9 HR HSF4 IL16 ITGB4 KRTAP10-8 KRTAP13-2 KRTAP13-3 KRTAP15-1 KRTAP26-1 KRTAP4-11 KRTAP4-12 KRTAP6-1 KRTAP9-3 KRTAP9-8 LCE1B LCE2B LCE3A LCE3D LCE4A LCE5A LMO4 LRRC41 MAPKBP1 MRPL40 MYPOP NOTCH2NLA NTAQ1 OTX1 PATZ1 PCSK5 PHLDA1 PKIB PLSCR4 POLR1C PTPMT1 PVR RBPMS RECK REEP6 RNF44 SAMD7 SAXO4 SLC5A5 SMARCC1 SPAG8 SPMIP9 TEKT3 TLX3 TNS2 VASN VENTX VGLL3 WDR25 YPEL3 ZFHX2 ZNF414 ZNF446
Entrez ID		6528	83896
HPRD ID		03504	13937
Ensembl ID		ENSG00000105641	ENSG00000212901
Uniprot IDs		Q92911	Q9BYR8
PDB IDs
Enriched GO Terms of Interacting Partners?			Intermediate Filament Protein Binding Keratinization Keratin Filament Epidermis Development Axonemal A Tubule Inner Sheath Tissue Development Ventral Spinal Cord Interneuron Differentiation Heart Trabecula Morphogenesis Cellular Response To Cell-matrix Adhesion
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