MRPL44 and USP22

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		MRPL44	USP22
Gene Name		mitochondrial ribosomal protein L44	ubiquitin specific peptidase 22
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cellular_component Mitochondrial Inner Membrane Ribosome	SAGA Complex SAGA-type Complex
	Molecular Function	Ribonuclease III Activity Poly(A) RNA Binding	Transcription Coactivator Activity Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding Zinc Ion Binding H4 Histone Acetyltransferase Activity Enzyme Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity
	Biological Process	RNA Processing Organelle Organization Mitochondrial Translation Mitochondrial Translational Initiation Mitochondrial Translational Elongation Mitochondrial Translational Termination RNA Phosphodiester Bond Hydrolysis, Endonucleolytic	Chromatin Organization Transcription, DNA-templated Cell Cycle Embryo Development Histone Ubiquitination Histone Deubiquitination Protein Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Histone H4 Acetylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Mitotic Cell Cycle Regulation Of Proteasomal Protein Catabolic Process
Pathways		Mitochondrial translation Organelle biogenesis and maintenance Mitochondrial translation elongation Mitochondrial translation initiation Mitochondrial translation termination	Chromatin modifying enzymes Chromatin organization HATs acetylate histones
Drugs
Diseases
GWAS
Protein-Protein Interactions		15 interactors: ABI2 CEP70 DGKE IMMT ITFG1 NGEF PI4KA PPAP2C PTN SEMA5B SETDB1 SHC1 USP22 VIM ZNF235	9 interactors: AASDHPPT HEXA HIST2H2AC HIST2H2BE MRPL10 MRPL44 PSME1 SCFD1 UBC
Entrez ID		65080	23326
HPRD ID		14763	19411
Ensembl ID		ENSG00000135900	ENSG00000124422
Uniprot IDs		Q9H9J2	Q9UPT9
PDB IDs
Enriched GO Terms of Interacting Partners?			Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Mitochondrial Translational Elongation Mitochondrial Translational Initiation Mitochondrial Translational Termination Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Transferase Activity Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Ligase Activity DNA Damage Response, Signal Transduction By P53 Class Mediator Mitochondrial Translation Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Signal Transduction In Response To DNA Damage Mitotic DNA Damage Checkpoint Regulation Of Cell Cycle Arrest Mitotic DNA Integrity Checkpoint Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Protein Ubiquitination Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Signal Transduction By P53 Class Mediator Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Autophagic Vacuole Assembly Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Ubiquitination Regulation Of Cell Cycle G1/S Phase Transition Translational Termination Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Cellular Protein Catabolic Process DNA Damage Checkpoint Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Positive Regulation Of Wnt Signaling Pathway G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Checkpoint Protein Polyubiquitination Translational Elongation Cellular Protein Complex Disassembly
Tagcloud ?			activates additionally along arrests clinicopathologic curbs downregulates g0 g1 great immunoprecipitation inhibits interacts mdmx nsclc oncology overexpressed phases promotes protease represent reverses shows shrna silencing tumorigenesis ubiquitin upregulation xenograft
Tagcloud (Difference) ?			activates additionally along arrests clinicopathologic curbs downregulates g0 g1 great immunoprecipitation inhibits interacts mdmx nsclc oncology overexpressed phases promotes protease represent reverses shows shrna silencing tumorigenesis ubiquitin upregulation xenograft
Tagcloud (Intersection) ?