MRPL1 and VPS52

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MRPL1	VPS52
Description		mitochondrial ribosomal protein L1	VPS52 subunit of GARP complex
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Large Ribosomal Subunit Ribosome Large Ribosomal Subunit Ribonucleoprotein Complex	GARP Complex Endosome Golgi Apparatus Cytosol Endosome Membrane Membrane Trans-Golgi Network Membrane Perinuclear Region Of Cytoplasm Recycling Endosome Presynapse Postsynapse EARP Complex
	Molecular Function	RNA Binding Structural Constituent Of Ribosome Protein Binding	Protein Binding Syntaxin Binding
	Biological Process	Translation Mitochondrial Translation	Protein Targeting Golgi To Vacuole Transport Lysosomal Transport Ectodermal Cell Differentiation Protein Transport Endocytic Recycling Retrograde Transport, Endosome To Golgi Embryonic Ectodermal Digestive Tract Development Vesicle-mediated Cholesterol Transport
Pathways		Mitochondrial translation initiation Mitochondrial translation elongation Mitochondrial translation elongation Mitochondrial translation termination Mitochondrial ribosome-associated quality control	Retrograde transport at the Trans-Golgi-Network
Drugs
Diseases
GWAS		Night sleep phenotypes ( 27126917)	Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 26426971)
Interacting Genes		6 interacting genes: APP GOPC PRPF6 SPAG16 UBC VPS52	101 interacting genes: AAMP AIRIM ARNT2 ATP6V1D BYSL C1orf216 CABP5 CACNA1A CATSPERT CCDC102B CCDC13 CCDC146 CCDC185 CCDC187 CCDC33 CCDC57 CCHCR1 CDC20B CDC5L CDK18 CEP19 CFAP206 CWF19L2 DCX DDX6 DNAJC11 DTNB EPM2AIP1 FAM110A FAM161A FAM161B FAM184A FAM50B GEM GFM2 GOLGA1 GORASP2 GPKOW HAUS1 HDAC4 HEATR1 HGS HOXB5 JAKMIP2 KANK2 KIAA1217 KIF5B KIF9 KIFC3 KLC3 KLHL42 LMO4 LNX1 MAGEL2 MAPK3 METTL13 MFAP1 MRPL1 MRPL11 NDC80 NFKBIB NOP2 NR2C2AP OTUD6A PIMREG PKN3 PPP1R18 PRKAA1 PRKAA2 RAB4A RAB4B RABEP2 RUNX1T1 SCNM1 SH2D4A SMARCE1 STX11 TAB2 TBC1D1 TBC1D22B TCEANC TCP11L1 TEAD4 THAP11 TPM3 TRAF4 TRAF6 TSSK3 TSTD2 TXLNB TXN2 USP2 VEZF1 VPS28 VPS53 WASHC3 WTAP ZC2HC1C ZMAT2 ZNF417 ZNF587
Entrez ID		65008	6293
HPRD ID		14737	09142
Ensembl ID		ENSG00000169288	ENSG00000223501
Uniprot IDs		Q9BYD6	A0A1U9X8S4 B3KMF7 B4DS44 Q4VXZ2 Q8N1B4
PDB IDs		7A5K 7QI4 7QI5 7QI6 8ANY 8OIR 8OIT 8RRI
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Recycling Endosome Trans-Golgi Network Membrane Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Vesicle-mediated Transport To The Plasma Membrane Embryonic Ectodermal Digestive Tract Development Post-Golgi Vesicle-mediated Transport Negative Regulation Of Anion Channel Activity Axonemal Central Apparatus Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling GARP Complex EARP Complex Ectodermal Cell Differentiation Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Microtubule-based Transport Negative Regulation Of Protein Localization Axon Choice Point Recognition Presynapse Postsynapse Heparan Sulfate Binding Signaling Receptor Activator Activity Vesicle-mediated Cholesterol Transport Peptidase Activator Activity	Protein Binding Cytoskeleton Organelle Assembly Centrosome Microtubule Binding Microtubule-based Process Histone H2BS36 Kinase Activity [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Organelle Organization Organelle Disassembly Ciliary Basal Body Kinesin Complex Protein Localization To Lipid Droplet Protein Localization To Vacuole Microtubule Cytoskeleton Organization Protein Localization To Lysosome Negative Regulation Of Tubulin Deacetylation Negative Regulation Of Hepatocyte Apoptotic Process AMP-activated Protein Kinase Activity Insulin-responsive Compartment Centriole
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