USP46 and PHLPP1

Number of citations of the paper that reports this interaction (PMID 22391563)
6

Data Source:
BioGRID (enzymatic study)

		USP46	PHLPP1
Gene Name		ubiquitin specific peptidase 46	PH domain and leucine rich repeat protein phosphatase 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component		Nucleus Cytosol Membrane
	Molecular Function	Ubiquitin-specific Protease Activity Protein Binding	Phosphoprotein Phosphatase Activity Protein Binding Metal Ion Binding
	Biological Process	Behavioral Fear Response Ubiquitin-dependent Protein Catabolic Process Adult Feeding Behavior Protein Deubiquitination Regulation Of Synaptic Transmission, GABAergic Behavioral Response To Ethanol Righting Reflex	Apoptotic Process Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Entrainment Of Circadian Clock Dephosphorylation Fc-epsilon Receptor Signaling Pathway Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling
Pathways			Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling Signaling by EGFRvIII in Cancer Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF DAP12 interactions Signalling by NGF GAB1 signalosome Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 Signaling by Overexpressed Wild-Type EGFR in Cancer Negative regulation of the PI3K/AKT network Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System
Drugs
Diseases
GWAS		Biochemical measures ( 19260141)
Protein-Protein Interactions		4 interactors: HIST2H2AC HIST2H2BE PHLPP1 UBC	4 interactors: CSNK1A1 GSK3B USP1 USP46
Entrez ID		64854	23239
HPRD ID		07507	15145
Ensembl ID		ENSG00000109189	ENSG00000081913
Uniprot IDs		P62068	O60346
PDB IDs
Enriched GO Terms of Interacting Partners?		Innate Immune Response Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Immune Response Defense Response Fc Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Viral Protein Processing	Protein Deubiquitination Peptidyl-serine Phosphorylation Protein Modification By Small Protein Removal Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Type B Pancreatic Cell Development Superior Temporal Gyrus Development Cellular Protein Modification Process Regulation Of Proteasomal Protein Catabolic Process Re-entry Into Mitotic Cell Cycle Negative Regulation Of Neuron Maturation Regulation Of Canonical Wnt Signaling Pathway Hypermethylation Of CpG Island Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Cellular Response To Interleukin-3 Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Regulation Of Synaptic Transmission Righting Reflex Regulation Of Neuron Maturation Negative Regulation Of Glycogen (starch) Synthase Activity Cellular Protein Metabolic Process Protein Localization To Microtubule Negative Regulation Of Dendrite Morphogenesis Negative Regulation Of NFAT Protein Import Into Nucleus Monoubiquitinated Protein Deubiquitination Regulation Of Protein Catabolic Process ER Overload Response Adult Feeding Behavior Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Muscle Hypertrophy Regulation Of Glycogen (starch) Synthase Activity Behavioral Response To Ethanol Regulation Of Cell Morphogenesis Positive Regulation Of Protein Export From Nucleus Regulation Of Type B Pancreatic Cell Development Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Dendrite Development Modification-dependent Protein Catabolic Process Protein Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Regulation Of DNA Methylation Myoblast Fusion Reflex Protein Localization To Cytoskeleton Protein Catabolic Process Regulation Of Proteolysis
Tagcloud ?		4e anoxia anticancer biomarker bp1 chemoresistance colon decreasing deprivation destabilizes deubiquitinase downregulated downregulation feature functionally hif1alpha hif2alpha hypoxia hypoxic isoforms knocking mtor partially phlpp phosphatases rescued ser thr tsc2	alphat alphatp angiogenesis biochem dissociation hek293 heterodimer htap htap1 inactive inc lipid location mediator overexpressed periodicals phosphatidylinositol pi3kgamma pkb reactivated sec14l2 sensor stimulates tocopherol tocopheryl translate vasculogenesis vegf wiley
Tagcloud (Difference) ?		4e anoxia anticancer biomarker bp1 chemoresistance colon decreasing deprivation destabilizes deubiquitinase downregulated downregulation feature functionally hif1alpha hif2alpha hypoxia hypoxic isoforms knocking mtor partially phlpp phosphatases rescued ser thr tsc2	alphat alphatp angiogenesis biochem dissociation hek293 heterodimer htap htap1 inactive inc lipid location mediator overexpressed periodicals phosphatidylinositol pi3kgamma pkb reactivated sec14l2 sensor stimulates tocopherol tocopheryl translate vasculogenesis vegf wiley
Tagcloud (Intersection) ?