USP46

Description		ubiquitin specific peptidase 46
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Synapse Glutamatergic Synapse
	Molecular Function	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Metal Ion Binding Deubiquitinase Activity
	Biological Process	Behavioral Fear Response Proteolysis Adult Feeding Behavior Protein Deubiquitination Regulation Of Protein Stability Regulation Of Synaptic Transmission, GABAergic Behavioral Response To Ethanol Righting Reflex Regulation Of Postsynaptic Neurotransmitter Receptor Internalization
Pathways
Drugs
Diseases
GWAS		Biochemical measures ( 19260141) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Height ( 31562340) Platelet count ( 29403010) Subcortical volume (MOSTest) ( 32665545) Type 2 diabetes ( 30297969)
Novel Interacting Genes		2 novel interacting genes: CEP135 FXR1
Interacting Genes		6 interacting genes: GRIA1 H2AC20 H2BC21 MAPK8IP2 UBA52 UBC
Entrez ID		64854
HPRD ID		07507
Ensembl ID		ENSG00000109189
Uniprot IDs		P62068
PDB IDs		5CVM 5CVN 5CVO 5L8H 6JLQ
Enriched GO Terms of Interacting Partners?		Endocytic Vesicle Membrane Protein Tag Activity Positive Regulation Of Locomotion Involved In Locomotory Behavior Axonal Spine Amyloid-beta Binding Regulation Of Nervous System Process Modulation Of Excitatory Postsynaptic Potential Cellular Response To Amine Stimulus Regulation Of Behavior Perisynaptic Space Response To Toxic Substance Modulation Of Chemical Synaptic Transmission Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Regulation Of Synaptic Transmission, Glutamatergic Protein Heterodimerization Activity Nucleosome Structural Constituent Of Chromatin Response To Psychosocial Stress Response To Fungicide Conditioned Place Preference Regulation Of Locomotion Involved In Locomotory Behavior Glutamate Receptor Binding Response To Sucrose Immunoglobulin Binding Response To Ammonium Ion Cellular Response To Ammonium Ion Dendritic Spine AMPA Glutamate Receptor Activity Ionotropic Glutamate Receptor Complex Learning Beta-2 Adrenergic Receptor Binding Response To Disaccharide Cellular Component Assembly Ribosome Vesicle Response To Insecticide RNA Strand Annealing Activity Nuclear Pore Localization Intracellular Membraneless Organelle Nonassociative Learning Regulation Of Synaptic Plasticity Neuron Spine Cellular Response To Brain-derived Neurotrophic Factor Stimulus Glutamate-gated Calcium Ion Channel Activity Proximal Dendrite Cellular Response To L-glutamate Mitochondrial Outer Membrane Positive Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Non-motile Cilium Assembly Signal Complex Assembly
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