RBM15 and CD2

		RBM15	CD2
Description		RNA binding motif protein 15	CD2 molecule
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GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nucleoplasm Membrane Nuclear Speck Nuclear Membrane RNA N6-methyladenosine Methyltransferase Complex	Extracellular Region Nucleoplasm Golgi Apparatus Plasma Membrane Cell-cell Junction External Side Of Plasma Membrane Cytoplasmic Side Of Plasma Membrane Cell Surface Membrane Protein-containing Complex
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding	Signaling Receptor Binding Protein Binding Protein Kinase Binding Receptor Tyrosine Kinase Binding Signaling Receptor Activity Identical Protein Binding
	Biological Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome RNA Methylation Branching Involved In Blood Vessel Morphogenesis Positive Regulation Of Transcription Of Notch Receptor Target Dosage Compensation By Inactivation Of X Chromosome Thrombopoietin-mediated Signaling Pathway Regulation Of Myeloid Cell Differentiation Negative Regulation Of Myeloid Cell Differentiation Regulation Of Megakaryocyte Differentiation Negative Regulation Of DNA-templated Transcription Spleen Development Ventricular Septum Morphogenesis Placenta Blood Vessel Development	Membrane Raft Polarization Apoptotic Process Immune Response Cell Adhesion Cell Surface Receptor Signaling Pathway Natural Killer Cell Activation Positive Regulation Of Myeloid Dendritic Cell Activation Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Heterotypic Cell-cell Adhesion T Cell Activation Natural Killer Cell Mediated Cytotoxicity Regulation Of T Cell Differentiation Cell-cell Adhesion
Pathways			Cell surface interactions at the vascular wall
Drugs			Alefacept Siplizumab
Diseases
GWAS			Body mass index ( 28552196) Gout (normal type) ( 32238385) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 31604244) Rheumatoid arthritis ( 24390342 30423114) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676)
Interacting Genes		17 interacting genes: ABI1 AZGP1P2 CALCOCO2 CEBPA CEP44 CLK1 CNOT4 CTTN DDX17 KRT31 LZTS2 MAPK8 NAV2 PRMT1 SRPK2 TSPYL2 USP7	21 interacting genes: CD247 CD2AP CD2BP2 CD4 CD48 CD5 CD53 CD58 CD59 DNAJC5 FYN LCK LGALS1 LINC00311 LYAR MXD1 PSTPIP1 PTPRC SH3KBP1 SP1 UBC
Entrez ID		64783	914
HPRD ID		05832	01750
Ensembl ID		ENSG00000162775	ENSG00000116824
Uniprot IDs		Q96T37	P06729 Q53F96
PDB IDs		7Z27	1CDB 1GYA 1HNF 1L2Z 1QA9 2J6O 2J7I
Enriched GO Terms of Interacting Partners?			T Cell Receptor Signaling Pathway Immune System Process Regulation Of Immune System Process Positive Regulation Of Immune System Process Antigen Receptor-mediated Signaling Pathway Regulation Of Immune Response Positive Regulation Of Lymphocyte Activation T Cell Costimulation Positive Regulation Of Cell Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Activation Of Immune Response Positive Regulation Of T Cell Activation Positive Regulation Of Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Leukocyte Cell-cell Adhesion Lymphocyte Activation Gamma-delta T Cell Activation Plasma Membrane Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Immune Response-activating Signaling Pathway Leukocyte Activation Membrane Raft Negative Regulation Of Immune Response Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation CD8 Receptor Binding Fc-gamma Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Cell Activation Cell Activation Positive Regulation Of Cell Adhesion T Cell Activation Regulation Of Cell-cell Adhesion Natural Killer Cell Activation Fc Receptor Signaling Pathway CD4 Receptor Binding Positive Regulation Of Gamma-delta T Cell Differentiation Phospholipase Activator Activity Positive Regulation Of Gamma-delta T Cell Activation Gamma-delta T Cell Differentiation Regulation Of Gamma-delta T Cell Differentiation Immune Response T Cell Receptor Binding Positive Regulation Of Leukocyte Differentiation Cell-cell Junction Extracellular Exosome Signaling Receptor Binding Positive Regulation Of Viral Entry Into Host Cell Positive Regulation Of Multicellular Organismal Process
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