ZDHHC6 and GOT2

Number of citations: 0 (PubMedID 16169070)
Data Source: HPRD (two hybrid)

		ZDHHC6	GOT2
Name		zDHHC palmitoyltransferase 6	glutamic-oxaloacetic transaminase 2
Structure		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Membrane	Mitochondrion Mitochondrial Matrix Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Protein Binding Palmitoyltransferase Activity Transferase Activity Acyltransferase Activity Protein-cysteine S-palmitoyltransferase Activity Protein-cysteine S-stearoyltransferase Activity	RNA Binding Catalytic Activity L-aspartate:2-oxoglutarate Aminotransferase Activity Transaminase Activity Kynurenine-oxoglutarate Transaminase Activity Transferase Activity Pyridoxal Phosphate Binding
	Biological Process	Protein Targeting To Membrane Intracellular Signal Transduction	2-oxoglutarate Metabolic Process Oxaloacetate Metabolic Process Amino Acid Metabolic Process Aspartate Metabolic Process Aspartate Biosynthetic Process L-aspartate Catabolic Process Glutamate Metabolic Process L-glutamate Catabolic Process Lipid Transport Fatty Acid Transport Trans-4-hydroxy-L-proline Catabolic Process L-glutamate Catabolic Process To Aspartate Malate-aspartate Shuttle Response To Ethanol
Pathways		None	Degradation of cysteine and homocysteine Glyoxylate metabolism and glycine degradation Aspartate and asparagine metabolism Glutamate and glutamine metabolism Malate-aspartate shuttle
Drugs		None	Pyridoxal phosphate Aspartic acid Glutamic acid Cysteine 4'-Deoxy-4'-Acetylyamino-Pyridoxal-5'-Phosphate
GWAS		Basophil count ( 32888494 ) High chromosomal aberration frequency (chromosome type) in genotoxic compound exposure ( 31586183 ) Metabolite levels ( 23823483 )	Aortic root size ( 21223598 ) Aspartate aminotransferase levels ( 29403010 33339817 33547301 ) Automobile speeding propensity ( 30643258 ) High density lipoprotein cholesterol levels ( 33339817 ) Impulsivity (attentional) ( 30718321 ) Metabolite levels ( 23823483 ) QT interval ( 19305408 ) Serum metabolite levels ( 33031748 ) Triglyceride levels ( 32203549 ) Urinary metabolite levels in chronic kidney disease ( 31959995 ) Uterine fibroid number (single vs multiple) ( 30196971 )
Novel Interactors		None recorded	2 novel interactors: BBS2 CSNK2A2
Interacting Genes		2 interacting genes: GOT2 KHDRBS1	10 interacting genes: APCS CCL21 GAPDH GLRX GLUD1 HSPA8 MDH2 PC THOC7 ZDHHC6
Entrez ID		64429	2806
HPRD ID		15721	00684
Ensembl ID		ENSG00000023041	ENSG00000125166
Uniprot IDs		A0A0D9SEX5 A0A804HJ40 Q9H6R6	P00505
PDB IDs		Not available	5AX8 8SKR
GO Terms Enriched among Interactors		L-glutamate Catabolic Process To Aspartate L-aspartate:2-oxoglutarate Aminotransferase Activity Aspartate Biosynthetic Process Grb2-Sos Complex L-aspartate Catabolic Process Trans-4-hydroxy-L-proline Catabolic Process Kynurenine-oxoglutarate Transaminase Activity Oxaloacetate Metabolic Process L-glutamate Catabolic Process Malate-aspartate Shuttle Aspartate Metabolic Process Positive Regulation Of RNA Export From Nucleus Dicarboxylic Acid Catabolic Process Transaminase Activity 2-oxoglutarate Metabolic Process Poly(U) RNA Binding Regulation Of RNA Export From Nucleus Poly(A) Binding Glutamate Metabolic Process Modified Amino Acid Catabolic Process Molecular Function Inhibitor Activity Aspartate Family Amino Acid Metabolic Process NAD+ Metabolic Process SH2 Domain Binding Protein Tyrosine Kinase Binding Positive Regulation Of Translational Initiation Pyridoxal Phosphate Binding G2/M Transition Of Mitotic Cell Cycle Cell Cycle G2/M Phase Transition Glutamine Family Amino Acid Metabolic Process Positive Regulation Of Nucleocytoplasmic Transport Amino Acid Biosynthetic Process RNA Binding Regulation Of Alternative MRNA Splicing, Via Spliceosome Fatty Acid Transport L-amino Acid Catabolic Process Proteinogenic Amino Acid Catabolic Process Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Signaling Adaptor Activity Dicarboxylic Acid Metabolic Process Amino Acid Catabolic Process Regulation Of Translational Initiation SH3 Domain Binding T Cell Receptor Signaling Pathway Regulation Of MRNA Splicing, Via Spliceosome Nicotinamide Nucleotide Metabolic Process Response To Ethanol Regulation Of Nucleocytoplasmic Transport	Glucose Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Nicotinamide Nucleotide Metabolic Process Purine Nucleotide Metabolic Process Nucleotide Metabolic Process Hexose Metabolic Process Small Molecule Metabolic Process Monosaccharide Metabolic Process Purine-containing Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Nucleoside Phosphate Metabolic Process Chaperone-mediated Autophagy Translocation Complex Disassembly NAD+ Metabolic Process L-malate Dehydrogenase (NADP+) Activity Hexose Biosynthetic Process Gluconeogenesis Pyruvate Carboxylase Activity Dendritic Cell Dendrite Assembly Negative Regulation Of Dendritic Cell Dendrite Assembly Host-mediated Perturbation Of Viral Process Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Peptidyl-cysteine S-trans-nitrosylation Glyceraldehyde-3-phosphate Dehydrogenase (NAD+) (phosphorylating) Activity Glutathione Disulfide Oxidoreductase Activity Glutamate Dehydrogenase (NAD+) Activity Oxidoreductase Activity, Acting On The CH-NH2 Group Of Donors, NAD Or NADP As Acceptor Glutamate Dehydrogenase (NADP+) Activity Glutamate Dehydrogenase [NAD(P)+] Activity Lumenal Side Of Lysosomal Membrane Viral RNA Genome Packaging Positive Regulation Of Myeloid Dendritic Cell Chemotaxis Mesangial Cell-matrix Adhesion CCR7 Chemokine Receptor Binding CCL21-activated CCR7 Signaling Pathway Cerebral Cortex Development Dicarboxylic Acid Metabolic Process Protein Kinase CK2 Complex Peptidyl-cysteine S-nitrosylase Activity Regulation Of Protein Import L-malate Dehydrogenase (NAD+) Activity Malate Dehydrogenase Activity Regulation Of Dendritic Cell Dendrite Assembly Unfolded Protein Binding Host-mediated Perturbation Of Symbiont Process Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Carbohydrate Metabolic Process Peptidyl-cysteine S-nitrosylation GAIT Complex Mitochondrial Matrix Protein Targeting To Lysosome Involved In Chaperone-mediated Autophagy