KLHL25 and ACLY

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology)

		KLHL25	ACLY
Description		kelch like family member 25	ATP citrate lyase
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cul3-RING Ubiquitin Ligase Complex	Extracellular Region Nucleoplasm Cytoplasm Cytosol Membrane Azurophil Granule Lumen Ciliary Basal Body Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Nucleotide Binding Catalytic Activity ATP Citrate Synthase Activity Protein Binding ATP Binding Transferase Activity Metal Ion Binding Acyltransferase Activity, Acyl Groups Converted Into Alkyl On Transfer
	Biological Process	Regulation Of Translation Regulation Of Translational Initiation Ubiquitin-dependent Protein Catabolic Process Fatty Acid Biosynthetic Process Protein Ubiquitination Positive Regulation Of CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Negative Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Fatty Acid Oxidation Proteolysis Involved In Protein Catabolic Process Regulation Of Primary Metabolic Process	Acetyl-CoA Biosynthetic Process Citrate Metabolic Process Oxaloacetate Metabolic Process Lipid Metabolic Process Fatty Acid Biosynthetic Process Cholesterol Biosynthetic Process Lipid Biosynthetic Process Coenzyme A Metabolic Process Negative Regulation Of Ferroptosis
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	ChREBP activates metabolic gene expression Neutrophil degranulation Fatty acyl-CoA biosynthesis
Drugs			Bempedoic acid
Diseases
GWAS		Adverse response to chemotherapy in breast cancer (alopecia) (anti-microtubule) ( 24025145) Adverse response to chemotherapy in breast cancer (alopecia) (docetaxel) ( 24025145) Aging traits ( 17903295) Appendicular lean mass ( 33097823) Birth weight ( 31043758) Idiopathic pulmonary fibrosis ( 29066090) Offspring birth weight ( 31043758) Psychosis (methamphetamine induced) ( 23594818) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355)	High light scatter reticulocyte percentage of red cells ( 27863252)
Interacting Genes		1 interacting genes: ACLY	10 interacting genes: APP CDKN2A CEBPA DDIAS FXR1 GSK3B HGS KLHL25 PRKACA USP7
Entrez ID		64410	47
HPRD ID		07780	00155
Ensembl ID		ENSG00000183655	ENSG00000131473
Uniprot IDs		Q9H0H3	P53396
PDB IDs			3MWD 3MWE 3PFF 5TDE 5TDF 5TDM 5TDZ 5TE1 5TEQ 5TES 5TET 6HXH 6HXK 6HXL 6HXM 6O0H 6POE 6POF 6QFB 6UI9 6UIA 6UUW 6UUZ 6UV5 6Z2H 7LIW 7LJ9 7LLA 7RIG 7RKZ 7RMP 8G1E 8G1F 8G5C 8G5D
Enriched GO Terms of Interacting Partners?		Citrate Metabolic Process ATP Citrate Synthase Activity Acyltransferase Activity, Acyl Groups Converted Into Alkyl On Transfer Signal Peptidase Complex Oxaloacetate Metabolic Process Negative Regulation Of Ferroptosis Coenzyme A Metabolic Process Acetyl-CoA Biosynthetic Process Regulation Of Ferroptosis Signal Peptide Processing Tricarboxylic Acid Metabolic Process Cholesterol Biosynthetic Process Acetyl-CoA Metabolic Process Sterol Biosynthetic Process Azurophil Granule Lumen Acyl-CoA Metabolic Process Steroid Biosynthetic Process Dicarboxylic Acid Metabolic Process Sulfur Compound Biosynthetic Process	Regulation Of Protein Metabolic Process Regulation Of Proteolysis Regulation Of Protein Catabolic Process Negative Regulation Of Multicellular Organismal Process Regulation Of Protein Export From Nucleus Negative Regulation Of Catabolic Process Regulation Of Long-term Synaptic Potentiation Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Cell Differentiation Regulation Of Proteasomal Protein Catabolic Process Postsynapse Regulation Of Developmental Process Regulation Of Establishment Of Protein Localization Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Catabolic Process P53 Binding Regulation Of Cell Cycle Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Intracellular Transport TOR Signaling Negative Regulation Of Metabolic Process Negative Regulation Of TOR Signaling Regulation Of Calcium-mediated Signaling Positive Regulation Of Gene Expression Negative Regulation Of Long-term Synaptic Potentiation Regulation Of Small Molecule Metabolic Process Regulation Of Multicellular Organismal Process Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Developmental Process Regulation Of Circadian Rhythm Negative Regulation Of Small Molecule Metabolic Process Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Protein Metabolic Process Negative Regulation Of Signal Transduction Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Cell Development Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Export From Nucleus Regulation Of Translation Intracellular Signaling Cassette Regulation Of Gene Expression Negative Regulation Of Signaling Positive Regulation Of Cell Differentiation Negative Regulation Of Cell Communication Negative Regulation Of Proteolysis Regulation Of Intracellular Protein Transport
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