KLHL25

Description		kelch like family member 25
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Regulation Of Translation Regulation Of Translational Initiation Ubiquitin-dependent Protein Catabolic Process Fatty Acid Biosynthetic Process Protein Ubiquitination Positive Regulation Of CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Negative Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Fatty Acid Oxidation Proteolysis Involved In Protein Catabolic Process Regulation Of Primary Metabolic Process
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Adverse response to chemotherapy in breast cancer (alopecia) (anti-microtubule) ( 24025145) Adverse response to chemotherapy in breast cancer (alopecia) (docetaxel) ( 24025145) Aging traits ( 17903295) Appendicular lean mass ( 33097823) Birth weight ( 31043758) Idiopathic pulmonary fibrosis ( 29066090) Offspring birth weight ( 31043758) Psychosis (methamphetamine induced) ( 23594818) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355)
Novel Interacting Genes		1 novel interacting genes: SEC11A
Interacting Genes		1 interacting genes: ACLY
Entrez ID		64410
HPRD ID		07780
Ensembl ID		ENSG00000183655
Uniprot IDs		Q9H0H3
PDB IDs
Enriched GO Terms of Interacting Partners?		Citrate Metabolic Process ATP Citrate Synthase Activity Acyltransferase Activity, Acyl Groups Converted Into Alkyl On Transfer Signal Peptidase Complex Oxaloacetate Metabolic Process Negative Regulation Of Ferroptosis Coenzyme A Metabolic Process Acetyl-CoA Biosynthetic Process Regulation Of Ferroptosis Signal Peptide Processing Tricarboxylic Acid Metabolic Process Cholesterol Biosynthetic Process Acetyl-CoA Metabolic Process Sterol Biosynthetic Process Azurophil Granule Lumen Acyl-CoA Metabolic Process Steroid Biosynthetic Process Dicarboxylic Acid Metabolic Process Sulfur Compound Biosynthetic Process
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