SFTPB and CTSH

Number of citations of the paper that reports this interaction (PMID 14766755)
22

Data Source:
HPRD (in vitro)

		SFTPB	CTSH
Gene Name		surfactant protein B	cathepsin H
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Lysosome	Outer Dense Fiber Acrosomal Vesicle Extracellular Space Lysosome Cytosol Extracellular Vesicular Exosome Alveolar Lamellar Body
	Molecular Function		Endopeptidase Activity Aminopeptidase Activity Cysteine-type Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process HLA-A Specific Activating MHC Class I Receptor Activity Kininogen Binding Protein Complex Binding Protein Self-association Thyroid Hormone Binding
	Biological Process	Sphingolipid Metabolic Process Respiratory Gaseous Exchange Organ Morphogenesis	Metanephros Development T Cell Mediated Cytotoxicity Adaptive Immune Response Immune Response-regulating Signaling Pathway Proteolysis Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Spermatogenesis Positive Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Neuropeptide Catabolic Process Bradykinin Catabolic Process Positive Regulation Of Peptidase Activity Antigen Processing And Presentation Positive Regulation Of Cell Migration Zymogen Activation Protein Destabilization Response To Retinoic Acid Membrane Protein Proteolysis Negative Regulation Of Apoptotic Process Surfactant Homeostasis Positive Regulation Of Angiogenesis Dichotomous Subdivision Of Terminal Units Involved In Lung Branching ERK1 And ERK2 Cascade Cellular Response To Thyroid Hormone Stimulus Positive Regulation Of Apoptotic Signaling Pathway
Pathways			MHC class II antigen presentation Adaptive Immune System
Drugs
Diseases
GWAS			Bipolar disorder ( 21771265) Type 1 diabetes ( 19430480 18978792)
Protein-Protein Interactions		1 interactors: CTSH	5 interactors: BGLAP CSTA CSTB SFTPB XRN1
Entrez ID		6439	1512
HPRD ID		01523	00288
Ensembl ID		ENSG00000168878
Uniprot IDs		D6W5L6 P07988	P09668
PDB IDs		1DFW 1KMR 1RG3 1RG4 1SSZ 2DWF 2JOU	1BZN
Enriched GO Terms of Interacting Partners?		Neuropeptide Catabolic Process Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Bradykinin Catabolic Process Cellular Response To Thyroid Hormone Stimulus T Cell Mediated Cytotoxicity Surfactant Homeostasis Peptide Catabolic Process Chemical Homeostasis Within A Tissue Response To Thyroid Hormone ERK1 And ERK2 Cascade Protein Destabilization Leukocyte Mediated Cytotoxicity T Cell Mediated Immunity Membrane Protein Proteolysis Epithelial Tube Branching Involved In Lung Morphogenesis Lung Morphogenesis Positive Regulation Of Epithelial Cell Migration Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Metanephros Development Zymogen Activation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Response To Retinoic Acid Positive Regulation Of Angiogenesis Positive Regulation Of Endopeptidase Activity Regulation Of Protein Stability Regulation Of Epithelial Cell Migration Positive Regulation Of Peptidase Activity Peptide Metabolic Process Tissue Homeostasis Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Branching Morphogenesis Of An Epithelial Tube Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Angiogenesis MAPK Cascade Multicellular Organismal Homeostasis Protein Processing Morphogenesis Of A Branching Epithelium Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Lung Development Morphogenesis Of A Branching Structure Cellular Amide Metabolic Process Respiratory Tube Development Leukocyte Mediated Immunity Adaptive Immune Response Signal Transduction By Phosphorylation Respiratory System Development Antigen Processing And Presentation	Response To Vitamin K Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Nuclear MRNA Surveillance Response To Hydroxyisoflavone RNA Surveillance Histone MRNA Catabolic Process Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing RRNA Catabolic Process Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Response To Gravity Cellular Response To Vitamin D Histone MRNA Metabolic Process Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Osteoblast Development Response To Vitamin D Regulation Of Proteolysis Regulation Of Bone Resorption Response To Testosterone Cellular Response To Nutrient Regulation Of Bone Remodeling Peptide Cross-linking Negative Regulation Of Catalytic Activity Response To Zinc Ion Bone Mineralization Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Negative Regulation Of Cellular Protein Metabolic Process Response To Activity Respiratory Gaseous Exchange
Tagcloud ?		accelerated airflow biomarker burden canadian computed copd ct decline emphysema ex expiratory fev1 forced fvc inversely limitation obstructive pan plasma positively predict pro scans severity smokers surfactant tomography vital	17a 23r arntl atf5 ccl20 ccr6 cd40lg ceacam1 covert cxcr6 faslg furin isg20 ltb map3k4 mcam permissiveness ppargamma pseudotyped ptk2 ptpn13 rorc rosiglitazone serpinb6 th1 th1th17 tnfsf13b tnfsf25 vsv
Tagcloud (Difference) ?		accelerated airflow biomarker burden canadian computed copd ct decline emphysema ex expiratory fev1 forced fvc inversely limitation obstructive pan plasma positively predict pro scans severity smokers surfactant tomography vital	17a 23r arntl atf5 ccl20 ccr6 cd40lg ceacam1 covert cxcr6 faslg furin isg20 ltb map3k4 mcam permissiveness ppargamma pseudotyped ptk2 ptpn13 rorc rosiglitazone serpinb6 th1 th1th17 tnfsf13b tnfsf25 vsv
Tagcloud (Intersection) ?