TMEM72 and MS4A1

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		TMEM72	MS4A1
Name		transmembrane protein 72	membrane spanning 4-domains A1
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Membrane Early Endosome Membrane	Extracellular Space Nucleoplasm Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Plasma Membrane Raft Extracellular Exosome
	Molecular Function	Protein Binding	Epidermal Growth Factor Receptor Binding Protein Binding Immunoglobulin Binding MHC Class II Protein Complex Binding Identical Protein Binding
	Biological Process	None	Store-operated Calcium Entry Humoral Immune Response Cell Surface Receptor Signaling Pathway Response To Bacterium B Cell Differentiation B Cell Proliferation B Cell Activation B Cell Receptor Signaling Pathway Protein Tetramerization Calcium Ion Import Into Cytosol Positive Regulation Of Calcium Ion Import Across Plasma Membrane
Drugs		None	Rituximab Ibritumomab tiuxetan Tositumomab Ofatumumab Obinutuzumab Technetium Tc-99m nofetumomab merpentan Ublituximab Ocrelizumab Mosunetuzumab Odronextamab
GWAS		Body mass index ( 25760438 ) Diastolic blood pressure ( 27841878 ) Moderate or severe prolonged lymphopenia in dimethyl fumarate-treated relapsing-remitting multiple sclerosis ( 31749835 ) Refractive error ( 32231278 ) Selective IgA deficiency ( 27723758 )	Recurrent major depressive disorder ( 29317602 )
Interacting Genes		10 interacting genes: BCL2L13 CERS4 FAM209A FXYD6 GJA8 LENEP MS4A1 PIGY SLC35A5 TMEM237	41 interacting genes: ACKR2 AQP6 CD40 CERS4 CLEC14A CREB3 CREB3L1 CSNK2A1 CSNK2A2 FAM209A FCRL3 FYN GORAB GPR42 HSD17B11 HSD17B13 IL7R KASH5 LCK LEUTX LMNA LYN MDM2 MMD MTIF3 REEP2 REEP4 RNF19B RNF5 SLC10A1 SLC10A6 SLC18A1 SLC35H1 SLC71A2 THAP4 TMEM31 TMEM72 TMEM82 TMPPE TMX2 TSPO2
Entrez ID		643236	931
HPRD ID		Not available	00204
Ensembl ID		ENSG00000187783	ENSG00000156738
Uniprot IDs		A0PK05	P11836
PDB IDs		Not available	2OSL 3BKY 3PP4 6VJA 6Y90 6Y92 6Y97 6Y9A 8VGN 8VGO
GO Terms Enriched among Interactors		None	Membrane Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Signaling Pathway Protein Kinase CK2 Complex Steroid Dehydrogenase Activity CD8 Receptor Binding Bile Acid:sodium Symporter Activity Fc-gamma Receptor Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Lymphocyte Activation Lymphocyte Proliferation Mononuclear Cell Proliferation B Cell Proliferation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway T Cell Costimulation CD4 Receptor Binding Non-membrane Spanning Protein Tyrosine Kinase Activity Endoplasmic Reticulum Endoplasmic Reticulum Membrane Peptidyl-tyrosine Phosphorylation Monocarboxylic Acid Transport Phospholipase Activator Activity Negative Regulation Of B Cell Receptor Signaling Pathway Positive Regulation Of Cell Activation Fc Receptor Signaling Pathway Leukocyte Proliferation T Cell Receptor Binding Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Regulation Of B Cell Proliferation Organic Hydroxy Compound Transport Protein Binding Response To Xenobiotic Stimulus Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity Adaptive Immune Response Phosphatidylinositol 3-kinase Binding Negative Regulation Of Apoptotic Process Transmembrane Transport Protein Kinase Activity Negative Regulation Of Programmed Cell Death Stimulatory C-type Lectin Receptor Signaling Pathway Phospholipase Binding Cellular Response To Lectin Bile Acid And Bile Salt Transport Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Endoplasmic Reticulum Tubular Network Endoplasmic Reticulum Tubular Network Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Lymphocyte Activation Nuclear Envelope Organization