TMEM72 and PIGY

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TMEM72	PIGY
Description		transmembrane protein 72	phosphatidylinositol glycan anchor biosynthesis class Y
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Membrane Early Endosome Membrane	Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) Complex Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane
	Molecular Function	Protein Binding	Protein Binding Phosphatidylinositol N-acetylglucosaminyltransferase Activity
	Biological Process		GPI Anchor Biosynthetic Process
Pathways			Synthesis of glycosylphosphatidylinositol (GPI)
Drugs
Diseases
GWAS		Body mass index ( 25760438) Diastolic blood pressure ( 27841878) Moderate or severe prolonged lymphopenia in dimethyl fumarate-treated relapsing-remitting multiple sclerosis ( 31749835) Refractive error ( 32231278) Selective IgA deficiency ( 27723758)	Bipolar disorder ( 22925353) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		10 interacting genes: BCL2L13 CERS4 FAM209A FXYD6 GJA8 LENEP MS4A1 PIGY SLC35A5 TMEM237	5 interacting genes: ABCB4 ERG28 FBXO7 PIGA TMEM72
Entrez ID		643236	84992
HPRD ID			17492
Ensembl ID		ENSG00000187783	ENSG00000255072
Uniprot IDs		A0PK05	Q3MUY2
PDB IDs
Enriched GO Terms of Interacting Partners?			Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Cellular Response To Bile Acid Response To Fenofibrate Ceramide Floppase Activity Ceramide Translocation Lewy Body Core Intercellular Canaliculus Positive Regulation Of Phospholipid Translocation Bile Acid Secretion Sphingolipid Translocation Response To Bile Acid Phosphatidylcholine Floppase Activity Phosphatidylinositol N-acetylglucosaminyltransferase Activity Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) Complex Lipid Metabolic Process ATPase-coupled Intramembrane Lipid Transporter Activity Positive Regulation Of Phospholipid Transport Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
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