FMNL2 and NECAB1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FMNL2	NECAB1
Description		formin like 2	N-terminal EF-hand calcium binding protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Nucleoplasm Cytoplasm Cytosol Cilium
	Molecular Function	Actin Binding Small GTPase Binding Cadherin Binding Actin Filament Binding	Calcium Ion Binding Protein Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Cytoskeleton Organization Regulation Of Cell Shape Cell Migration Regulation Of Cell Morphogenesis Actin Cytoskeleton Organization Cortical Actin Cytoskeleton Organization	Blastocyst Hatching Regulation Of Amyloid Precursor Protein Biosynthetic Process
Pathways		RHO GTPases Activate Formins RHOC GTPase cycle CDC42 GTPase cycle
Drugs
Diseases
GWAS		Asthma (childhood onset) ( 27611488) Corneal astigmatism ( 30306274) Glaucoma ( 30054594) Glaucoma (primary open-angle) ( 29891935 33627673) Heel bone mineral density ( 30598549) Intraocular pressure ( 29235454 29617998 29785010 30054594 31959993) Lymphocyte count ( 32888494) Refractive astigmatism ( 30306274) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) White blood cell count ( 32888494)	Age at first sexual intercourse ( 34211149)
Interacting Genes		15 interacting genes: AP1B1 AP2B1 APP CCDC197 CDC42 KRT27 LCOR MIPOL1 NECAB1 NRIP1 PKNOX1 PNMA1 PRPF40A SUOX TTC3	19 interacting genes: AP1M1 APP ATOX1 BHLHA9 BRPF1 CDC37 CPNE4 CPNE7 CPNE8 DAPK1 DISC1 FMNL2 LNX1 MORF4L1 PAX4 PCNT SNX11 TCEA2 TCEANC
Entrez ID		114793	64168
HPRD ID		13545	16851
Ensembl ID		ENSG00000157827	ENSG00000123119
Uniprot IDs		Q96PY5	Q8N987
PDB IDs		4YC7
Enriched GO Terms of Interacting Partners?			Cellular Response To Metal Ion Calcium-dependent Phospholipid Binding Cellular Response To Calcium Ion Intracellular Copper Ion Homeostasis Copper Ion Homeostasis
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