DUS1L and CAMK2G

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DUS1L	CAMK2G
Description		dihydrouridine synthase 1 like	calcium/calmodulin dependent protein kinase II gamma
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Nucleoplasm Cytoplasm Cytosol Calcium- And Calmodulin-dependent Protein Kinase Complex Postsynaptic Density Membrane Sarcoplasmic Reticulum Endocytic Vesicle Membrane Sarcoplasmic Reticulum Membrane Neuron Projection
	Molecular Function	Protein Binding Oxidoreductase Activity TRNA Dihydrouridine Synthase Activity Flavin Adenine Dinucleotide Binding TRNA-dihydrouridine16 Synthase Activity TRNA-dihydrouridine17 Synthase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity Calcium-dependent Protein Serine/threonine Phosphatase Activity Protein Binding Calmodulin Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Protein Homodimerization Activity Protein Serine Kinase Activity
	Biological Process	TRNA Dihydrouridine Synthesis TRNA Processing	Nervous System Development Regulation Of Neuron Projection Development Regulation Of Skeletal Muscle Adaptation Insulin Secretion Cell Differentiation Regulation Of Neuronal Synaptic Plasticity Regulation Of Calcium Ion Transport Long-term Synaptic Potentiation Regulation Of Protein Localization To Plasma Membrane
Pathways			CaMK IV-mediated phosphorylation of CREB HSF1-dependent transactivation Trafficking of AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Ras activation upon Ca2+ influx through NMDA receptor Phase 0 - rapid depolarisation Ion homeostasis RAF activation RAF/MAP kinase cascade Signaling by moderate kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Interferon gamma signaling Regulation of MECP2 expression and activity Ion transport by P-type ATPases Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation Signaling downstream of RAS mutants Signaling by RAF1 mutants
Drugs			Bosutinib 1-tert-butyl-3-(3-methylbenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine Fostamatinib
Diseases
GWAS		Refractive error ( 32231278) Triacylglycerol 56:6 levels ( 31560688)	Body size at age 10 ( 32376654) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Crohn's disease ( 28067908) FEV1 ( 30804560) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Multiple sclerosis ( 31604244) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Peak expiratory flow ( 30804560) Psoriasis ( 25939698) Psoriasis vulgaris ( 26626624) Systemic lupus erythematosus ( 28714469) Type 2 diabetes ( 30054458)
Interacting Genes		5 interacting genes: CAMK2B CAMK2G DAPK1 MEOX2 OGT	51 interacting genes: ACTN2 ACTN4 ADCY3 ATF1 CABP2 CALM1 CDC37 CEBPA CHAT CREM DUS1L EGFR ESRRG FLNA FXR1 FXR2 GRIA1 GRIA4 GRIN1 GRIN2B KANK2 KRTAP19-3 KRTAP6-1 KRTAP6-3 LRRC7 MAP3K7 MRPL11 MYLK NUTF2 NXF1 PEA15 PLCB3 PSMB1 PTEN RCHY1 RRAD RYR1 SMAD2 SMAD3 SMAD4 SPR STAT1 STMN1 STRBP SYN1 TH TIAM1 TNPO2 TNPO3 TTC5 UBE2I
Entrez ID		64118	818
HPRD ID		17885	03672
Ensembl ID		ENSG00000169718	ENSG00000148660
Uniprot IDs		Q6P1R4	A0A2Q3DQE3 B3KY86 H0Y6G2 Q13280 Q13555 Q5SWX3
PDB IDs			2UX0 2V7O
Enriched GO Terms of Interacting Partners?		Calcium/calmodulin-dependent Protein Kinase Activity Calcium- And Calmodulin-dependent Protein Kinase Complex Regulation Of Skeletal Muscle Adaptation Regulation Of Protein Localization To Cell Periphery Regulation Of Protein Localization To Membrane Calmodulin Binding Postsynaptic Density Sarcoplasmic Reticulum Membrane Protein Serine Kinase Activity Long-term Synaptic Potentiation Regulation Of Neuronal Synaptic Plasticity Protein Serine/threonine Kinase Activity Sarcoplasmic Reticulum Endocytic Vesicle Membrane Regulation Of Cellular Localization Protein Kinase Activity DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Regulation Of Protein Localization To Plasma Membrane Kinase Activity Protein Autophosphorylation Transferase Activity Positive Regulation Of Synaptic Transmission Calcium-dependent Protein Serine/threonine Phosphatase Activity Protein O-acetylglucosaminyltransferase Activity Negative Regulation Of Translation Regulation Of NMDA Receptor Activity Regulation Of Synaptic Plasticity Regulation Of Protein Localization Somite Specification Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Cell Migration Regulation Of Calcium Ion Transport Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Regulation Of Cell Motility Regulation Of Synapse Structural Plasticity Regulation Of Muscle System Process Carbon Catabolite Regulation Of Transcription Regulation Of Locomotion Positive Regulation Of Synapse Maturation Cellular Response To Hydroperoxide Regulation Of Transcription By Glucose Defense Response To Tumor Cell Regulation Of Synapse Organization NSL Complex Negative Regulation Of Cell Migration	Intracellular Signaling Cassette Intracellular Signal Transduction Cytoplasm Synapse Cytosol Neuron Projection SMAD Protein Complex Identical Protein Binding Learning Or Memory Modulation Of Chemical Synaptic Transmission Glutamate-gated Calcium Ion Channel Activity Ionotropic Glutamate Receptor Signaling Pathway Heteromeric SMAD Protein Complex Positive Regulation Of Excitatory Postsynaptic Potential Ligand-gated Monoatomic Ion Channel Activity Cognition Chemical Synaptic Transmission Regulation Of Membrane Potential Dendritic Spine Signal Transduction Trans-synaptic Signaling Ligand-gated Ion Channel Signaling Pathway Calcium Ion Transmembrane Import Into Cytosol Synaptic Signaling Positive Regulation Of Signal Transduction Positive Regulation Of RNA Metabolic Process Kinase Binding Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Modulation Of Excitatory Postsynaptic Potential I-SMAD Binding Postsynaptic Density Membrane Glutamate Receptor Signaling Pathway Transcription Coactivator Binding Regulation Of Monoatomic Ion Transmembrane Transport Activin Responsive Factor Complex Paraxial Mesoderm Morphogenesis Regulation Of Epithelial To Mesenchymal Transition Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Calmodulin Binding Regulation Of Neuronal Synaptic Plasticity Nuclear Import Signal Receptor Activity Regulation Of Monoatomic Ion Transport Regulation Of Synaptic Plasticity Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Cell Communication Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cell Surface Receptor Signaling Pathway Cell Development Positive Regulation Of Signaling Ameboidal-type Cell Migration
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?