STEEP1 and HAT1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		STEEP1	HAT1
Description		STING1 ER exit protein 1	histone acetyltransferase 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Centrosome Membrane Cell Body	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Cytoplasm Mitochondrion Nuclear Matrix Protein-containing Complex
	Molecular Function	Protein Binding Protein-macromolecule Adaptor Activity	Histone Acetyltransferase Activity Protein Binding Histone H4 Acetyltransferase Activity Transferase Activity Acyltransferase Activity Histone Binding Histone H4K12 Acetyltransferase Activity Protein-lysine-acetyltransferase Activity
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Positive Regulation Of Type I Interferon Production Protein Exit From Endoplasmic Reticulum Endoplasmic Reticulum Membrane Organization CGAS/STING Signaling Pathway	Chromatin Organization Nucleosome Assembly Internal Protein Amino Acid Acetylation Subtelomeric Heterochromatin Formation Chromosome Organization
Pathways		mRNA Splicing - Major Pathway	HATs acetylate histones
Drugs
Diseases
GWAS			Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Myopia ( 27182965) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		9 interacting genes: APP CEBPA HAT1 KIF9 PDCL2 PIBF1 RBM4 RPRD1B SNW1	23 interacting genes: ACAA1 CEBPA EZH2 H2AC20 H3-4 H3C1 H4C14 H4C16 HTR2B KANK4 MEOX2 MORN5 PRKAA2 REL SMAD7 SNAPC1 STEEP1 TCF4 TEPSIN TNFAIP1 TRIB3 YWHAQ ZSCAN4
Entrez ID		63932	8520
HPRD ID		06541	04339
Ensembl ID		ENSG00000018610	ENSG00000128708
Uniprot IDs		Q9H5V9	A0AAG2UVM1 O14929
PDB IDs		8C6J 9FMD	2P0W 6VO5 9MJG
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Negative Regulation Of Metabolic Process Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Positive Regulation Of Protein Metabolic Process Regulation Of Response To Calcium Ion Positive Regulation Of Gene Expression Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Biosynthetic Process Positive Regulation Of Endothelin Production Negative Regulation Of Macromolecule Biosynthetic Process Growth Cone Filopodium Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Lipoprotein Particle Positive Regulation Of Cell Differentiation Microtubule-based Process Notch Signaling Pathway Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Microtubule-based Movement Positive Regulation Of Macromolecule Biosynthetic Process CHOP-C/EBP Complex Nuclear Matrix RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Vitamin B2 C/EBP Complex Cap-independent Translational Initiation Pre-mRNA Intronic Pyrimidine-rich Binding MRNA Processing IRES-dependent Translational Initiation Of Linear MRNA Circadian Regulation Of Translation Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Interleukin-4 Receptor Binding Negative Regulation Of Prostaglandin Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Gene Expression Cellular Response To Norepinephrine Stimulus Memory Astrocyte Activation Involved In Immune Response	Structural Constituent Of Chromatin Protein Heterodimerization Activity Nucleosome Chromosome, Telomeric Region Protein-DNA Complex Assembly DNA Binding Nucleosome Assembly Negative Regulation Of Chondrocyte Proliferation Negative Regulation Of Cell Differentiation Sequence-specific DNA Binding Chromatin Remodeling Chromosome Nucleosome Organization Telomere Organization Protein Localization To Chromatin Chromatin Organization Regulation Of Cell Differentiation Nucleus Nucleoplasm Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Developmental Process CENP-A Containing Nucleosome Protein Localization To CENP-A Containing Chromatin Negative Regulation Of Megakaryocyte Differentiation Regulation Of Gene Expression Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Stem Cell Differentiation Regulation Of Macromolecule Metabolic Process Protein Localization To Chromosome Protein-containing Complex Cardiac Muscle Hypertrophy Positive Regulation Of Proteasomal Protein Catabolic Process Muscle Hypertrophy Regulation Of Cell Development Positive Regulation Of Cartilage Development Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Metabolic Process Acetate CoA-transferase Activity Phenylacetate Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Hepatocyte Homeostasis Beta-catenin Destruction Complex Disassembly Positive Regulation Of Chondrocyte Hypertrophy Chromosome Organization Protein Localization To Chromosome, Centromeric Region Regulation Of Megakaryocyte Differentiation Coated Vesicle Membrane
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