STEEP1 and PDCL2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		STEEP1	PDCL2
Description		STING1 ER exit protein 1	phosducin like 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Centrosome Membrane Cell Body	Cytoplasm Endoplasmic Reticulum
	Molecular Function	Protein Binding Protein-macromolecule Adaptor Activity
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Positive Regulation Of Type I Interferon Production Protein Exit From Endoplasmic Reticulum Endoplasmic Reticulum Membrane Organization CGAS/STING Signaling Pathway	Acrosome Assembly Protein Folding Spermatogenesis Spermatid Development Sperm Axoneme Assembly Cell Differentiation Flagellated Sperm Motility Sperm Flagellum Assembly
Pathways		mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS			A body shape index ( 34021172) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Daytime sleep phenotypes ( 27126917) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Height ( 31562340) Metabolite levels ( 23823483) Subcortical volume (MOSTest) ( 32665545) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		9 interacting genes: APP CEBPA HAT1 KIF9 PDCL2 PIBF1 RBM4 RPRD1B SNW1	5 interacting genes: GOLGA1 HYCC2 STEEP1 UNC13B YWHAB
Entrez ID		63932	132954
HPRD ID		06541	15109
Ensembl ID		ENSG00000018610	ENSG00000163440
Uniprot IDs		Q9H5V9	Q8N4E4
PDB IDs		8C6J 9FMD	3EVI
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Negative Regulation Of Metabolic Process Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Positive Regulation Of Protein Metabolic Process Regulation Of Response To Calcium Ion Positive Regulation Of Gene Expression Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Biosynthetic Process Positive Regulation Of Endothelin Production Negative Regulation Of Macromolecule Biosynthetic Process Growth Cone Filopodium Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Lipoprotein Particle Positive Regulation Of Cell Differentiation Microtubule-based Process Notch Signaling Pathway Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Microtubule-based Movement Positive Regulation Of Macromolecule Biosynthetic Process CHOP-C/EBP Complex Nuclear Matrix RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Vitamin B2 C/EBP Complex Cap-independent Translational Initiation Pre-mRNA Intronic Pyrimidine-rich Binding MRNA Processing IRES-dependent Translational Initiation Of Linear MRNA Circadian Regulation Of Translation Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Interleukin-4 Receptor Binding Negative Regulation Of Prostaglandin Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Gene Expression Cellular Response To Norepinephrine Stimulus Memory Astrocyte Activation Involved In Immune Response
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