CHTF18 and RFC4

Number of citations of the paper that reports this interaction (PMID 11486023)
41

Data Source:
HPRD (in vivo)

		CHTF18	RFC4
Gene Name		CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)	replication factor C (activator 1) 4, 37kDa
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Membrane	Nucleus Nucleoplasm DNA Replication Factor C Complex Cytoplasm
	Molecular Function	DNA Binding ATP Binding	DNA Clamp Loader Activity Protein Binding ATP Binding
	Biological Process	DNA Replication Reciprocal Meiotic Recombination Male Meiosis Spermatogenesis Negative Regulation Of Chromosome Segregation	Mitotic Cell Cycle Telomere Maintenance Via Recombination Telomere Maintenance DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Semi-conservative Replication
Pathways			Polymerase switching on the C-strand of the telomere Nucleotide Excision Repair Synthesis of DNA Chromosome Maintenance Lagging Strand Synthesis Gap-filling DNA repair synthesis and ligation in TC-NER G2/M Checkpoints Extension of Telomeres Repair synthesis for gap-filling by DNA polymerase in TC-NER S Phase Telomere C-strand (Lagging Strand) Synthesis Leading Strand Synthesis DNA strand elongation Repair synthesis of patch ~27-30 bases long by DNA polymerase Cell Cycle, Mitotic Gap-filling DNA repair synthesis and ligation in GG-NER Polymerase switching Global Genomic NER (GG-NER) Telomere Maintenance Transcription-coupled NER (TC-NER) Activation of ATR in response to replication stress Cell Cycle Checkpoints
Drugs
Diseases
GWAS			Activated partial thromboplastin time ( 22703881)
Protein-Protein Interactions		4 interactors: PCNA RFC3 RFC4 RFC5	11 interactors: BRD4 CDK4 CHTF18 HDAC1 PCNA RAD17 RFC1 RFC2 RFC3 RFC5 RNF41
Entrez ID		63922	5984
HPRD ID		13059	00022
Ensembl ID		ENSG00000127586	ENSG00000163918
Uniprot IDs		Q8WVB6	P35249
PDB IDs
Enriched GO Terms of Interacting Partners?		Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Semi-conservative Replication Nuclear DNA Replication Telomere Maintenance Via Recombination Mitotic Recombination DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening Transcription-coupled Nucleotide-excision Repair Telomere Maintenance Nucleotide-excision Repair DNA-dependent DNA Replication DNA Recombination DNA Replication DNA Repair Cellular Homeostasis Mitotic Cell Cycle Cellular Response To DNA Damage Stimulus Chromosome Organization Cell Cycle Process DNA Metabolic Process Cell Cycle Homeostatic Process Cellular Response To Stress DNA Biosynthetic Process Positive Regulation Of Deoxyribonuclease Activity Leading Strand Elongation Organelle Organization Response To Stress Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Translesion Synthesis Cellular Nitrogen Compound Metabolic Process DNA Synthesis Involved In DNA Repair Nitrogen Compound Metabolic Process Postreplication Repair Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Cellular Response To Stimulus Positive Regulation Of Nuclease Activity Response To Cadmium Ion Mismatch Repair Base-excision Repair Response To Stimulus Regulation Of DNA Replication Positive Regulation Of DNA Metabolic Process Response To Organophosphorus	Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Semi-conservative Replication Nuclear DNA Replication Telomere Maintenance Via Recombination Mitotic Recombination DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening Mitotic Cell Cycle Cell Cycle Transcription-coupled Nucleotide-excision Repair DNA Replication Cell Cycle Process Telomere Maintenance Nucleotide-excision Repair DNA Recombination DNA-dependent DNA Replication Chromosome Organization Cellular Response To DNA Damage Stimulus DNA Metabolic Process DNA Repair Organelle Organization Cellular Response To Stress Response To Stress Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cellular Homeostasis Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cellular Response To Stimulus Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Cell Cycle G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Nitrogen Compound Metabolic Process Cellular Metabolic Process Response To Stimulus Mitotic Cell Cycle Process Mitotic Cell Cycle Phase Transition Regulation Of G2/M Transition Of Mitotic Cell Cycle Cell Cycle Phase Transition Regulation Of Cell Cycle G2/M Phase Transition Homeostatic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Deoxyribonuclease Activity
Tagcloud ?			12q24 13q12 3q27 7q11 bands catalyzed chains chromosomes consisting dnas elongation epsilon hybrids locations mapped multimeric p145 p36 p37 p38 p40 panel primer processive q13 q24 rfc2 rfc3 rfc5
Tagcloud (Difference) ?			12q24 13q12 3q27 7q11 bands catalyzed chains chromosomes consisting dnas elongation epsilon hybrids locations mapped multimeric p145 p36 p37 p38 p40 panel primer processive q13 q24 rfc2 rfc3 rfc5
Tagcloud (Intersection) ?