SDHB and STMN1

		SDHB	STMN1
Description		succinate dehydrogenase complex iron sulfur subunit B	stathmin 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Plasma Membrane Membrane Mitochondrial Membrane Respiratory Chain Complex II (succinate Dehydrogenase)	Cytoplasm Cytosol Cytoskeleton Microtubule Membrane Neuron Projection Extracellular Exosome
	Molecular Function	Protein Binding Succinate Dehydrogenase (quinone) Activity Electron Transfer Activity Oxidoreductase Activity Metal Ion Binding Ubiquinone Binding Iron-sulfur Cluster Binding 2 Iron, 2 Sulfur Cluster Binding 3 Iron, 4 Sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding	Protein Binding Tubulin Binding
	Biological Process	Tricarboxylic Acid Cycle Succinate Metabolic Process Mitochondrial Electron Transport, Succinate To Ubiquinone Aerobic Respiration Respiratory Electron Transport Chain Proton Motive Force-driven Mitochondrial ATP Synthesis	Mitotic Cytokinesis Microtubule Depolymerization Mitotic Spindle Organization Signal Transduction Nervous System Development Axonogenesis Response To Virus Cell Differentiation Regulation Of Cell Migration Regulation Of Microtubule Polymerization Or Depolymerization Negative Regulation Of Microtubule Polymerization Neuron Projection Development Negative Regulation Of Rho Protein Signal Transduction Intracellular Signal Transduction Hepatocyte Growth Factor Receptor Signaling Pathway Negative Regulation Of Stress Fiber Assembly Establishment Of Skin Barrier Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Negative Regulation Of Guanyl-nucleotide Exchange Factor Activity
Pathways		Respiratory electron transport Citric acid cycle (TCA cycle) Maturation of TCA enzymes and regulation of TCA cycle	Nuclear signaling by ERBB4
Drugs		2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol Ubiquinone Q1
Diseases
GWAS		A body shape index ( 34021172) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Height ( 20189936) Hip circumference adjusted for BMI ( 34021172) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		8 interacting genes: ABCA1 CARTPT GEM MSRA PIK3R5 SPRY2 TMEM132D XRN1	21 interacting genes: CAMK2G CDK1 CDKN1B CEBPA CHEK2 CSNK2A1 ERBB2 FANCC GLP1R HSPA5 HSPA8 HUNK LINC00632 MAPK3 PRKACA PRKCA SEPTIN2 SESTD1 STAT3 UBQLN4 UHMK1
Entrez ID		6390	3925
HPRD ID		01707	01047
Ensembl ID		ENSG00000117118	ENSG00000117632
Uniprot IDs		A0AAQ5BHD9 P21912	A0A140VJW2 P16949
PDB IDs		7KCL 7KCM 7KLU 7KLV 8GS8
Enriched GO Terms of Interacting Partners?		Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Rho Protein Signal Transduction	Protein Serine Kinase Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Kinase Activity Phosphorylation Nucleotide Binding ATP Binding Nucleoplasm Protein Phosphorylation Regulation Of Protein Catabolic Process Intracellular Signal Transduction Response To Stress Regulation Of Protein Metabolic Process Cellular Response To Stress Signal Transduction In Response To DNA Damage Regulation Of Cellular Component Organization Phosphate-containing Compound Metabolic Process Regulation Of Cell Cycle Regulation Of Macroautophagy Regulation Of Proteasomal Protein Catabolic Process Regulation Of Autophagy Intracellular Signaling Cassette Regulation Of Transport Regulation Of Protein Localization Transferase Activity Signal Transduction Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Nutrient Levels Intracellular Protein Localization Ubiquitin Protein Ligase Binding Regulation Of Cellular Localization DNA Damage Response Regulation Of Establishment Of Protein Localization Regulation Of Cellular Response To Stress Post-translational Protein Targeting To Membrane, Translocation Intracellular Protein Transport Positive Regulation Of Catabolic Process ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cell Cycle Nucleic Acid Metabolic Process Mitotic Nuclear Membrane Disassembly Cellular Response To Glucagon Stimulus Positive Regulation Of Cell Population Proliferation Regulation Of Proteolysis Response To Hormone Protein Catabolic Process Negative Regulation Of Catabolic Process Interleukin-2-mediated Signaling Pathway
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