SDHA and WBP2

Number of citations of the paper that reports this interaction (PubMedID 27578003)
0

Data Source:
BioGRID (pull down)

		SDHA	WBP2
Description		succinate dehydrogenase complex flavoprotein subunit A	WW domain binding protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleolus Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Membrane Respiratory Chain Complex II (succinate Dehydrogenase)	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding Succinate Dehydrogenase (quinone) Activity Electron Transfer Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-CH Group Of Donors Flavin Adenine Dinucleotide Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Coactivator Activity Protein Binding Nuclear Estrogen Receptor Binding Chromatin DNA Binding
	Biological Process	Tricarboxylic Acid Cycle Succinate Metabolic Process Mitochondrial Electron Transport, Succinate To Ubiquinone Nervous System Development Electron Transport Chain Respiratory Electron Transport Chain Proton Motive Force-driven Mitochondrial ATP Synthesis	Response To Progesterone Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Response To Estrogen Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Progesterone Receptor Signaling Pathway Establishment Of Protein Localization To Chromatin Cellular Response To Estrogen Stimulus
Pathways		Respiratory electron transport Citric acid cycle (TCA cycle) Maturation of TCA enzymes and regulation of TCA cycle
Drugs		2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol Carboxin Thenoyltrifluoroacetone Ubiquinone Q1 Ubidecarenone
Diseases		Diseases of the tricarboxylic acid cycle, including: Fumarase (FH) deficiency; Succinate dehydrogenase (SDH) deficiency; Alpha-ketoglutarate dehydrogenase (AKGDH) deficiency Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Hip circumference adjusted for BMI ( 34021172)	Adult body size ( 32376654) Platelet count ( 32888494) Red blood cell count ( 32888494) White matter hyperintensities ( 32358547)
Interacting Genes		10 interacting genes: CDC42 CFTR CSNK2B DSCAM ERCC6 HSPB2 LCOR RSPH1 WBP2 XIAP	54 interacting genes: ANAPC1 ANKRD13A ANKRD13D ARCN1 BAG3 CCT7 CLEC4G COPA COPB1 COPB2 COPE COPG1 CUEDC1 DDX17 EEF1B2 EPN2 ESR1 GRPEL1 H4C1 HUWE1 ITCH KRT18 KRT8 KRT9 LGALS8 MAGEA4 MAGI1 MYO6 NEDD4 NEDD4L PAX8 POLH RHBDD3 RNF168 RPS27A RPS3 RUNX1 SDHA SEPTIN3 SMAD5 TDP2 TOLLIP TOM1L2 UBA52 UBC UBE2E3 UBE3A UBQLN1 UIMC1 WWC3 WWP1 WWP2 WWTR1 YAP1
Entrez ID		6389	23558
HPRD ID		02914	06097
Ensembl ID		ENSG00000073578	ENSG00000132471
Uniprot IDs		D6RFM5 P31040	A6NG10 Q969T9
PDB IDs		6VAX 8DYD 8DYE 8GS8
Enriched GO Terms of Interacting Partners?			COPI Vesicle Coat COPI-coated Vesicle Membrane Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Cytosol Protein Ubiquitination Protein Modification By Small Protein Conjugation COPI-coated Vesicle Intra-Golgi Vesicle-mediated Transport Macromolecule Catabolic Process Ubiquitin-protein Transferase Activity Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Protein Polyubiquitination Negative Regulation Of Potassium Ion Export Across Plasma Membrane Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Transport Vesicle Protein Monoubiquitination Nucleoplasm Protein K48-linked Ubiquitination Structural Molecule Activity Membrane Coat Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Proteolysis Cytoplasm Potassium Channel Inhibitor Activity Protein K63-linked Ubiquitination Regulation Of Potassium Ion Export Across Plasma Membrane Regulation Of Nephron Tubule Epithelial Cell Differentiation Extracellular Exosome Catabolic Process Protein Tag Activity Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Ubiquitin Protein Ligase Activity Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Proteasomal Protein Catabolic Process Nuclear Receptor-mediated Signaling Pathway Ubiquitin Binding Protein Catabolic Process Golgi Vesicle Transport Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Branched Polyubiquitination Histone Ubiquitin Ligase Activity Intracellular Protein Transport Negative Regulation Of Potassium Ion Transmembrane Transport Vesicle-mediated Transport Cytoplasmic Vesicle Cardiac Muscle Tissue Regeneration Intracellular Protein Localization Negative Regulation Of Cation Transmembrane Transport
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