SCN8A and FGF13

Number of citations of the paper that reports this interaction (PMID 15282281)
29

Data Source:
HPRD (two hybrid, in vivo)

		SCN8A	FGF13
Gene Name		sodium channel, voltage gated, type VIII alpha subunit	fibroblast growth factor 13
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Voltage-gated Sodium Channel Complex Plasma Membrane Integral Component Of Membrane Cytoplasmic Membrane-bounded Vesicle Z Disc Dendrite Node Of Ranvier Neuronal Cell Body Axon Initial Segment	Extracellular Region Nucleus Nucleolus Cytoplasm Microtubule Plasma Membrane Intercalated Disc Filopodium Axon Dendrite Growth Cone Neuron Projection
	Molecular Function	Voltage-gated Sodium Channel Activity ATP Binding	Protein Binding Microtubule Binding Growth Factor Activity Sodium Channel Regulator Activity Protein Kinase Activator Activity Ion Channel Binding Beta-tubulin Binding
	Biological Process	Sodium Ion Transport Nervous System Development Peripheral Nervous System Development Muscle Organ Development Sensory Perception Of Sound Adult Walking Behavior Response To Toxic Substance Neuronal Action Potential Regulation Of Ion Transmembrane Transport Sodium Ion Transmembrane Transport Myelination Neuromuscular Process Membrane Depolarization During Action Potential	MAPK Cascade Neuron Migration Negative Regulation Of Microtubule Depolymerization Signal Transduction Cell-cell Signaling Nervous System Development Learning Memory Hippocampus Development Cerebral Cortex Cell Migration Establishment Of Neuroblast Polarity Positive Regulation Of Protein Kinase Activity Microtubule Polymerization Negative Regulation Of Collateral Sprouting Protein Localization To Plasma Membrane
Pathways		Interaction between L1 and Ankyrins Axon guidance L1CAM interactions
Drugs
Diseases
GWAS			Response to taxane treatment (placlitaxel) ( 23006423)
Protein-Protein Interactions		3 interactors: FGF13 GNAO1 MAPK14	3 interactors: PRNP PSEN1 SCN8A
Entrez ID		6334	2258
HPRD ID		09006	02090
Ensembl ID		ENSG00000196876	ENSG00000129682
Uniprot IDs		Q9UQD0	A8K1P5 Q92913
PDB IDs			3HBW 4DCK
Enriched GO Terms of Interacting Partners?		P38MAPK Cascade MAPK Cascade Positive Regulation Of Catalytic Activity Establishment Of Neuroblast Polarity Signal Transduction By Phosphorylation Aging Positive Regulation Of Brown Fat Cell Differentiation Myoblast Differentiation Involved In Skeletal Muscle Regeneration Regulation Of Brown Fat Cell Differentiation Negative Regulation Of Collateral Sprouting Forebrain Development Regulation Of Catalytic Activity Positive Regulation Of Protein Kinase Activity 3'-UTR-mediated MRNA Stabilization Positive Regulation Of Kinase Activity Stress-induced Premature Senescence Positive Regulation Of Transferase Activity Behavior Organ Development Positive Regulation Of Myoblast Differentiation Positive Regulation Of Myoblast Fusion Response To Muramyl Dipeptide Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion Regulation Of Myoblast Fusion Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Cartilage Condensation Cell Differentiation Positive Regulation Of Metabolic Process Brain Development Skeletal Muscle Tissue Regeneration Regulation Of Kinase Activity Microtubule Polymerization MRNA Stabilization Head Development Somatic Stem Cell Division Response To Organonitrogen Compound Cellular Senescence Positive Regulation Of Phosphorylation Positive Regulation Of Myotube Differentiation Dopamine Receptor Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Erythrocyte Differentiation Negative Regulation Of Microtubule Depolymerization Lipopolysaccharide-mediated Signaling Pathway Response To Morphine Central Nervous System Development Negative Regulation Of Calcium Ion Transport Microtubule Polymerization Or Depolymerization	Single-organism Behavior Behavior Neurological System Process Cajal-Retzius Cell Differentiation Beta-amyloid Formation Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Learning Or Memory Regulation Of Membrane Potential Cognition Synaptic Vesicle Targeting Regulation Of Resting Membrane Potential Negative Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Protein Phosphorylation Negative Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Cellular Response To Copper Ion Choline Transport Negative Regulation Of Calcium-mediated Signaling Negative Regulation Of Phosphorylation Cellular Metal Ion Homeostasis Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Regulation Of Ion Transmembrane Transport Response To Oxidative Stress Nervous System Development Amyloid Precursor Protein Catabolic Process Cellular Cation Homeostasis Cellular Ion Homeostasis Negative Regulation Of Interleukin-17 Production Metal Ion Homeostasis Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Activated T Cell Proliferation Cellular Chemical Homeostasis Ion Homeostasis Negative Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Receptor Recycling Amyloid Precursor Protein Metabolic Process Regulation Of Ion Transport Negative Regulation Of Interleukin-2 Production Cellular Copper Ion Homeostasis Monovalent Inorganic Cation Transport Membrane Protein Ectodomain Proteolysis Beta-amyloid Metabolic Process Notch Receptor Processing Negative Regulation Of T Cell Receptor Signaling Pathway Cellular Homeostasis Response To Copper Ion Myeloid Dendritic Cell Differentiation Negative Regulation Of Receptor Activity Copper Ion Homeostasis Myeloid Dendritic Cell Activation L-glutamate Transport
Tagcloud ?		asah1 atypical broadening canada care4rare causal definitive descriptions encephalopathy epilepsy exome families folr1 forge grin2a kcnq2 nation projects rare recognizable retrospect segregating seizures suited syngap1 synj1 translating unrevealing wes	ag490 bms chx concert cox2 cycloheximide extrinsic hgf hsf igfbp4 igfbp6 igfl2 il1a il1b il1r1 il21r il31ra il6 iotal17beta iotal18 iotal19 iotal28beta mmp12 ptgs2 qrt rho stat3 substantially trail
Tagcloud (Difference) ?		asah1 atypical broadening canada care4rare causal definitive descriptions encephalopathy epilepsy exome families folr1 forge grin2a kcnq2 nation projects rare recognizable retrospect segregating seizures suited syngap1 synj1 translating unrevealing wes	ag490 bms chx concert cox2 cycloheximide extrinsic hgf hsf igfbp4 igfbp6 igfl2 il1a il1b il1r1 il21r il31ra il6 iotal17beta iotal18 iotal19 iotal28beta mmp12 ptgs2 qrt rho stat3 substantially trail
Tagcloud (Intersection) ?