SCN8A

Description		sodium voltage-gated channel alpha subunit 8
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GO Annotations	Cellular Component	Voltage-gated Sodium Channel Complex Podosome Plasma Membrane Membrane Z Disc Cell Junction Axon Cytoplasmic Vesicle Node Of Ranvier Monoatomic Ion Channel Complex Cell Projection Axon Initial Segment Anchoring Junction
	Molecular Function	Monoatomic Ion Channel Activity Voltage-gated Sodium Channel Activity Monoatomic Cation Channel Activity Sodium Channel Activity Protein Binding Sodium Ion Binding
	Biological Process	Action Potential Monoatomic Ion Transport Sodium Ion Transport Peripheral Nervous System Development Monoatomic Ion Transmembrane Transport Sodium Ion Transmembrane Transport Myelination Transmembrane Transport Cardiac Muscle Cell Action Potential Involved In Contraction
Pathways		Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation
Drugs		Ranolazine Phenytoin Topiramate Valproic acid Lamotrigine Carbamazepine Oxcarbazepine Cocaine Promethazine Chloroprocaine Tetrodotoxin Brivaracetam Tetracaine Amylocaine Propoxycaine Pramocaine Pentoxyverine Dichlorobenzyl alcohol Bioallethrin Fish oil
Diseases
GWAS		Alcohol consumption ( 31358974) Alcohol use disorder (consumption score) ( 30940813) Chronotype ( 30696823) Clozapine-induced agranulocytosis/granulocytopenia in treatment-resistant schizophrenia ( 27400856) Response to antidepressants and depression ( 27622933)
Novel Interacting Genes		2 novel interacting genes: ADAM9 OS9
Interacting Genes		4 interacting genes: FGF13 FGF14 GNAO1 MAPK14
Entrez ID		6334
HPRD ID		09006
Ensembl ID		ENSG00000196876
Uniprot IDs		A0A590UK43 Q6B4S4 Q9UQD0
PDB IDs		8FHD 8GZ1 8GZ2
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Transport Regulation Of Establishment Of Protein Localization MAPK Cascade Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion Regulation Of Transport Sodium Channel Regulator Activity Regulation Of Protein Localization Signal Transduction Glycosylation-dependent Protein Binding Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Intracellular Protein Transport Response To Tumor Necrosis Factor Regulation Of Synaptic Membrane Adhesion Regulation Of Voltage-gated Sodium Channel Activity Positive Regulation Of Voltage-gated Sodium Channel Activity Neurogenesis Establishment Of Neuroblast Polarity Negative Regulation Of Establishment Of Protein Localization Mu-type Opioid Receptor Binding Negative Regulation Of Protein Transport G Protein-coupled Serotonin Receptor Binding Growth Factor Activity Corticotropin-releasing Hormone Receptor 1 Binding Adenylate Cyclase Regulator Activity Metalloendopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Positive Regulation Of Macrophage Fusion Intracellular Signal Transduction Cellular Response To Lipopolysaccharide Cellular Response To Molecule Of Bacterial Origin Intracellular Signaling Cassette Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Mitogen-activated Protein Kinase P38 Binding Positive Regulation Of Transport NFAT Protein Binding Stress-induced Premature Senescence Positive Regulation Of Sodium Ion Transmembrane Transporter Activity Branching Morphogenesis Of A Nerve Negative Regulation Of Protein Localization Cell-cell Adhesion Mediated By Integrin Protein Retention In ER Lumen Hrd1p Ubiquitin Ligase Complex NLRP1 Inflammasome Complex Assembly Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Positive Regulation Of Protein Transport Negative Regulation Of Retrograde Protein Transport, ER To Cytosol Regulation Of Intracellular Transport Regulation Of Protein Secretion Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Monocyte Activation Negative Regulation Of Protein Exit From Endoplasmic Reticulum
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