FGF13 and SCN8A

Number of citations of the paper that reports this interaction (PubMedID 15282281)
49

Data Source:
HPRD (two hybrid, in vivo)

		FGF13	SCN8A
Description		fibroblast growth factor 13	sodium voltage-gated channel alpha subunit 8
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Microtubule Plasma Membrane Intercalated Disc Membrane Lateral Plasma Membrane Filopodium Axon Dendrite Growth Cone Sarcolemma Cell Projection Neuron Projection	Voltage-gated Sodium Channel Complex Podosome Plasma Membrane Membrane Z Disc Cell Junction Axon Cytoplasmic Vesicle Node Of Ranvier Monoatomic Ion Channel Complex Cell Projection Axon Initial Segment Anchoring Junction
	Molecular Function	Protein Binding Microtubule Binding Growth Factor Activity Sodium Channel Regulator Activity Transmembrane Transporter Binding Beta-tubulin Binding	Monoatomic Ion Channel Activity Voltage-gated Sodium Channel Activity Monoatomic Cation Channel Activity Sodium Channel Activity Protein Binding Sodium Ion Binding
	Biological Process	MAPK Cascade Neuron Migration Sodium Ion Transport Negative Regulation Of Microtubule Depolymerization Signal Transduction Cell-cell Signaling Nervous System Development Learning Or Memory Learning Memory Hippocampus Development Cerebral Cortex Cell Migration Neurogenesis Establishment Of Neuroblast Polarity Microtubule Polymerization Negative Regulation Of Collateral Sprouting Branching Morphogenesis Of A Nerve Protein Localization To Plasma Membrane Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Inhibitory Synapse Assembly Positive Regulation Of Voltage-gated Sodium Channel Activity	Action Potential Monoatomic Ion Transport Sodium Ion Transport Peripheral Nervous System Development Monoatomic Ion Transmembrane Transport Sodium Ion Transmembrane Transport Myelination Transmembrane Transport Cardiac Muscle Cell Action Potential Involved In Contraction
Pathways		Phase 0 - rapid depolarisation	Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation
Drugs			Ranolazine Phenytoin Topiramate Valproic acid Lamotrigine Carbamazepine Oxcarbazepine Cocaine Promethazine Chloroprocaine Tetrodotoxin Brivaracetam Tetracaine Amylocaine Propoxycaine Pramocaine Pentoxyverine Dichlorobenzyl alcohol Bioallethrin Fish oil
Diseases
GWAS		Breast cancer in BRCA2 mutation carriers ( 23544012) Response to taxane treatment (paclitaxel) ( 23006423)	Alcohol consumption ( 31358974) Alcohol use disorder (consumption score) ( 30940813) Chronotype ( 30696823) Clozapine-induced agranulocytosis/granulocytopenia in treatment-resistant schizophrenia ( 27400856) Response to antidepressants and depression ( 27622933)
Interacting Genes		9 interacting genes: APP ARHGAP5 FBXO7 MAPK8IP2 PLEKHF2 PRNP PSEN1 SCN8A VMP1	4 interacting genes: FGF13 FGF14 GNAO1 MAPK14
Entrez ID		2258	6334
HPRD ID		02090	09006
Ensembl ID		ENSG00000129682	ENSG00000196876
Uniprot IDs		A8K1P5 Q92913	A0A590UK43 Q6B4S4 Q9UQD0
PDB IDs		3HBW 4DCK 4JPZ	8FHD 8GZ1 8GZ2
Enriched GO Terms of Interacting Partners?		Neuron Projection Maintenance Regulation Of Neuron Apoptotic Process Neuron Projection Organization Regulation Of Apoptotic Signaling Pathway Astrocyte Activation Involved In Immune Response Positive Regulation Of Amyloid Fibril Formation Cellular Response To Amyloid-beta Growth Factor Receptor Binding Response To Amyloid-beta Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Regulation Of Biological Quality Learning Or Memory Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Negative Regulation Of Long-term Synaptic Potentiation Cognition Regulation Of Dendritic Spine Maintenance Intracellular Copper Ion Homeostasis Regulation Of Amyloid Fibril Formation Regulation Of Membrane Potential Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Mating Behavior Regulation Of Postsynapse Organization Astrocyte Activation Memory Regulation Of Programmed Cell Death Endoplasmic Reticulum Positive Regulation Of Glycolytic Process Negative Regulation Of Cell Communication Copper Ion Homeostasis Cellular Response To Copper Ion Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Molecular Function Activator Activity Modulation Of Chemical Synaptic Transmission Reproductive Behavior Positive Regulation Of Apoptotic Process Response To Copper Ion Early Endosome Membrane Regulation Of Synaptic Plasticity Positive Regulation Of Programmed Cell Death Positive Regulation Of ATP Metabolic Process Membrane Raft Dendritic Shaft Postsynapse Regulation Of Long-term Synaptic Potentiation Regulation Of Intracellular Signal Transduction	Regulation Of Protein Transport Regulation Of Establishment Of Protein Localization MAPK Cascade Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion Regulation Of Transport Sodium Channel Regulator Activity Regulation Of Protein Localization Signal Transduction Glycosylation-dependent Protein Binding Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Intracellular Protein Transport Response To Tumor Necrosis Factor Regulation Of Synaptic Membrane Adhesion Regulation Of Voltage-gated Sodium Channel Activity Positive Regulation Of Voltage-gated Sodium Channel Activity Neurogenesis Establishment Of Neuroblast Polarity Negative Regulation Of Establishment Of Protein Localization Mu-type Opioid Receptor Binding Negative Regulation Of Protein Transport G Protein-coupled Serotonin Receptor Binding Growth Factor Activity Corticotropin-releasing Hormone Receptor 1 Binding Adenylate Cyclase Regulator Activity Metalloendopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Positive Regulation Of Macrophage Fusion Intracellular Signal Transduction Cellular Response To Lipopolysaccharide Cellular Response To Molecule Of Bacterial Origin Intracellular Signaling Cassette Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Mitogen-activated Protein Kinase P38 Binding Positive Regulation Of Transport NFAT Protein Binding Stress-induced Premature Senescence Positive Regulation Of Sodium Ion Transmembrane Transporter Activity Branching Morphogenesis Of A Nerve Negative Regulation Of Protein Localization Cell-cell Adhesion Mediated By Integrin Protein Retention In ER Lumen Hrd1p Ubiquitin Ligase Complex NLRP1 Inflammasome Complex Assembly Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Positive Regulation Of Protein Transport Negative Regulation Of Retrograde Protein Transport, ER To Cytosol Regulation Of Intracellular Transport Regulation Of Protein Secretion Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Monocyte Activation Negative Regulation Of Protein Exit From Endoplasmic Reticulum
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