SCN8A and OS9

		SCN8A	OS9
Description		sodium voltage-gated channel alpha subunit 8	OS9 endoplasmic reticulum lectin
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GO Annotations	Cellular Component	Voltage-gated Sodium Channel Complex Podosome Plasma Membrane Membrane Z Disc Cell Junction Axon Cytoplasmic Vesicle Node Of Ranvier Monoatomic Ion Channel Complex Cell Projection Axon Initial Segment Anchoring Junction	Hrd1p Ubiquitin Ligase Complex Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane
	Molecular Function	Monoatomic Ion Channel Activity Voltage-gated Sodium Channel Activity Monoatomic Cation Channel Activity Sodium Channel Activity Protein Binding Sodium Ion Binding	Protease Binding Protein Binding Carbohydrate Binding Glycosylation-dependent Protein Binding
	Biological Process	Action Potential Monoatomic Ion Transport Sodium Ion Transport Peripheral Nervous System Development Monoatomic Ion Transmembrane Transport Sodium Ion Transmembrane Transport Myelination Transmembrane Transport Cardiac Muscle Cell Action Potential Involved In Contraction	Ubiquitin-dependent Protein Catabolic Process Protein Targeting Protein Retention In ER Lumen Intracellular Protein Localization Protein Ubiquitination Endoplasmic Reticulum Unfolded Protein Response Retrograde Protein Transport, ER To Cytosol Response To Endoplasmic Reticulum Stress ERAD Pathway Negative Regulation Of Retrograde Protein Transport, ER To Cytosol
Pathways		Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation	ABC-family proteins mediated transport Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Defective CFTR causes cystic fibrosis ER Quality Control Compartment (ERQC) AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
Drugs		Ranolazine Phenytoin Topiramate Valproic acid Lamotrigine Carbamazepine Oxcarbazepine Cocaine Promethazine Chloroprocaine Tetrodotoxin Brivaracetam Tetracaine Amylocaine Propoxycaine Pramocaine Pentoxyverine Dichlorobenzyl alcohol Bioallethrin Fish oil
Diseases
GWAS		Alcohol consumption ( 31358974) Alcohol use disorder (consumption score) ( 30940813) Chronotype ( 30696823) Clozapine-induced agranulocytosis/granulocytopenia in treatment-resistant schizophrenia ( 27400856) Response to antidepressants and depression ( 27622933)	Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Multiple sclerosis ( 31604244) Rheumatoid arthritis (ACPA-positive) ( 24532676)
Interacting Genes		4 interacting genes: FGF13 FGF14 GNAO1 MAPK14	19 interacting genes: ACVR1B CPNE6 CREB3 DCSTAMP DYSF EGLN1 EGLN3 EIF6 FOXM1 HIF1A LINC00839 MEP1B RBX1 SMAD2 SNRPD2 SREBF2 TRPV4 USP40 ZNF512B
Entrez ID		6334	10956
HPRD ID		09006	17804
Ensembl ID		ENSG00000196876	ENSG00000135506
Uniprot IDs		A0A590UK43 Q6B4S4 Q9UQD0	A0A8V8TPZ4 A0A8V8TQI8 A0A8V8TR34 Q13438
PDB IDs		8FHD 8GZ1 8GZ2	3AIH
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Transport Regulation Of Establishment Of Protein Localization MAPK Cascade Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion Regulation Of Transport Sodium Channel Regulator Activity Regulation Of Protein Localization Signal Transduction Glycosylation-dependent Protein Binding Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Intracellular Protein Transport Response To Tumor Necrosis Factor Regulation Of Synaptic Membrane Adhesion Regulation Of Voltage-gated Sodium Channel Activity Positive Regulation Of Voltage-gated Sodium Channel Activity Neurogenesis Establishment Of Neuroblast Polarity Negative Regulation Of Establishment Of Protein Localization Mu-type Opioid Receptor Binding Negative Regulation Of Protein Transport G Protein-coupled Serotonin Receptor Binding Growth Factor Activity Corticotropin-releasing Hormone Receptor 1 Binding Adenylate Cyclase Regulator Activity Metalloendopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Positive Regulation Of Macrophage Fusion Intracellular Signal Transduction Cellular Response To Lipopolysaccharide Cellular Response To Molecule Of Bacterial Origin Intracellular Signaling Cassette Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Mitogen-activated Protein Kinase P38 Binding Positive Regulation Of Transport NFAT Protein Binding Stress-induced Premature Senescence Positive Regulation Of Sodium Ion Transmembrane Transporter Activity Branching Morphogenesis Of A Nerve Negative Regulation Of Protein Localization Cell-cell Adhesion Mediated By Integrin Protein Retention In ER Lumen Hrd1p Ubiquitin Ligase Complex NLRP1 Inflammasome Complex Assembly Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Positive Regulation Of Protein Transport Negative Regulation Of Retrograde Protein Transport, ER To Cytosol Regulation Of Intracellular Transport Regulation Of Protein Secretion Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Monocyte Activation Negative Regulation Of Protein Exit From Endoplasmic Reticulum	Negative Regulation Of Ossification L-ascorbic Acid Binding Peptidyl-proline 4-dioxygenase Activity Hypoxia-inducible Factor-proline Dioxygenase Activity Regulation Of Ossification Regulation Of Generation Of Precursor Metabolites And Energy Intracellular Oxygen Homeostasis Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Nodal Signaling Pathway I-SMAD Binding Regulation Of MiRNA Transcription Peptide Hormone Secretion Regulation Of Macroautophagy Peptide Secretion Dioxygenase Activity Protein Hydroxylation Regulation Of Myeloid Cell Differentiation Regulation Of MiRNA Metabolic Process Negative Regulation Of Bone Mineralization 2-oxoglutarate-dependent Dioxygenase Activity Hormone Secretion Cellular Response To Stress Positive Regulation Of Transcription By RNA Polymerase II Hormone Transport Peptide Transport Ferrous Iron Binding Positive Regulation Of Myeloid Cell Differentiation Regulation Of Neuron Apoptotic Process Iron Ion Binding Negative Regulation Of MiRNA Transcription Positive Regulation Of Erythrocyte Differentiation Activin Receptor Signaling Pathway Ubiquitin Protein Ligase Binding Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Hypoxia Response To Decreased Oxygen Levels Regulation Of Apoptotic Process Response To Hypoxia Negative Regulation Of Biomineral Tissue Development Assembly Of Large Subunit Precursor Of Preribosome D-gluconate Metabolic Process Phosphogluconate Dehydrogenase (decarboxylating) Activity Type 1 Parathyroid Hormone Receptor Binding Parathyroid Hormone Receptor Binding Monoatomic Cation Channel Activity Positive Regulation Of Protein-containing Complex Disassembly Lytic Vacuole Monocyte Activation Involved In Immune Response Positive Regulation Of Deacetylase Activity Osmosensor Activity
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