SCN2B

Description		sodium voltage-gated channel beta subunit 2
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GO Annotations	Cellular Component	Voltage-gated Sodium Channel Complex Plasma Membrane Membrane T-tubule Axon Node Of Ranvier Cell Projection Axon Initial Segment Synapse
	Molecular Function	Voltage-gated Sodium Channel Activity Sodium Channel Regulator Activity Voltage-gated Sodium Channel Activity Involved In Cardiac Muscle Cell Action Potential Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization
	Biological Process	Monoatomic Ion Transport Sodium Ion Transport Chemical Synaptic Transmission Nervous System Development Response To Heat Gene Expression Positive Regulation Of Sodium Ion Transport Sodium Ion Transmembrane Transport Response To Pyrethroid Cardiac Muscle Contraction Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Cardiac Conduction Cardiac Muscle Cell Action Potential Involved In Contraction Membrane Depolarization During Action Potential Membrane Depolarization During Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential
Pathways		Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation Sensory perception of sweet, bitter, and umami (glutamate) taste
Drugs		Ranolazine Valproic acid Oxcarbazepine Cocaine Zonisamide Brivaracetam Dichlorobenzyl alcohol Fish oil
Diseases
GWAS		Preeclampsia ( 23551011)
Interacting Genes		2 interacting genes: CFTR SCN1B
Entrez ID		6327
HPRD ID		03208
Ensembl ID		ENSG00000149575
Uniprot IDs		O60939 Q5U0K8
PDB IDs		5FDY 5FEB 6J8E 6J8G 6J8H 6J8I 6J8J 6VRR 7W77 7W7F 7W9K 7W9L 7W9M 7W9P 7W9T 7XM9 7XMF 7XMG 7XVE 7XVF 8G1A 8GZ1 8GZ2 8I5B 8I5G 8I5X 8I5Y 8S9B 8S9C 8THG 8THH 8XMN 8XMO
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Ion Transmembrane Transporter Activity Positive Regulation Of Transporter Activity Regulation Of Transmembrane Transporter Activity Regulation Of Monoatomic Ion Transmembrane Transporter Activity Positive Regulation Of Monoatomic Ion Transmembrane Transport Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Monoatomic Ion Transport Corticospinal Neuron Axon Guidance Positive Regulation Of Anion Channel Activity Positive Regulation Of Voltage-gated Sodium Channel Activity Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Monoatomic Anion Transport Regulation Of Voltage-gated Sodium Channel Activity Membrane Depolarization During Purkinje Myocyte Cell Action Potential Positive Regulation Of Enamel Mineralization Transepithelial Water Transport Regulation Of Monoatomic Ion Transport Regulation Of Membrane Potential Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Sodium Channel Inhibitor Activity Positive Regulation Of Sodium Ion Transmembrane Transporter Activity Sodium Channel Complex Amelogenesis Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Action Potential Propagation Neuronal Action Potential Propagation Voltage-gated Sodium Channel Complex Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Inorganic Ion Transmembrane Transport Golgi-associated Vesicle Membrane Cellular Response To Forskolin Membrane Depolarization During Cardiac Muscle Cell Action Potential Monoatomic Ion Transmembrane Transport Response To Forskolin Positive Regulation Of Sodium Ion Transmembrane Transport Chloride Transmembrane Transporter Activity Sperm Capacitation Node Of Ranvier Positive Regulation Of Transport Membrane Depolarization During Action Potential
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