SCML1 and SFMBT2

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		SCML1	SFMBT2
Name		Scm polycomb group protein like 1	Scm like with four mbt domains 2
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus	Nucleus Nucleoplasm Cytosol Aggresome Nuclear Body Nuclear Speck
	Molecular Function	Chromatin Binding Protein Binding Histone Binding	Chromatin Binding Transcription Corepressor Activity Protein Binding Histone Binding
	Biological Process	Negative Regulation Of DNA-templated Transcription	Regulation Of DNA-templated Transcription Negative Regulation Of Gene Expression Negative Regulation Of DNA-templated Transcription
GWAS		Metabolite levels ( 23823483 )	Asthma (childhood onset) ( 31036433 ) Fasting blood insulin (BMI interaction) ( 22581228 ) Femoral neck bone mineral density ( 32239398 ) Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass ( 32239398 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Monoclonal gammopathy of undetermined significance ( 30737484 )
Interacting Genes		5 interacting genes: ITGB2 LNX1 RENBP SDCBP SFMBT2	13 interacting genes: AKT1 CLK1 ESR1 L3MBTL3 LYPLA1 PHC1 RNF181 SCMH1 SCML1 SCML2 SIAH1 SLF2 TFAP4
Entrez ID		6322	57713
HPRD ID		02205	18853
Ensembl ID		ENSG00000047634	ENSG00000198879
Uniprot IDs		Q9UN30	Q5VUG0
PDB IDs		Not available	1WJR
GO Terms Enriched among Interactors		Integrin AlphaM-beta2 Complex Integrin AlphaX-beta2 Complex Extracellular Vesicle Positive Regulation Of Exocytosis Integrin AlphaL-beta2 Complex N-acylglucosamine 2-epimerase Activity N-acetylmannosamine Metabolic Process Interleukin-5 Receptor Binding Interleukin-5 Receptor Complex Regulation Of Exocytosis ICAM-3 Receptor Activity Negative Regulation Of Dopamine Metabolic Process Positive Regulation Of Neutrophil Degranulation Positive Regulation Of Extracellular Exosome Assembly Syndecan Binding Membrane Raft Negative Regulation Of Catecholamine Metabolic Process N-acetylneuraminate Catabolic Process Regulation Of Extracellular Exosome Assembly Regulation Of Neutrophil Degranulation Positive Regulation Of Secretion By Cell Substrate-dependent Cell Migration, Cell Extension	Histone Binding Chromatin Binding Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nitric-oxide Synthase Regulator Activity Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Nucleus Negative Regulation Of Macromolecule Metabolic Process Protein Serine/threonine/tyrosine Kinase Activity PcG Protein Complex Maternal Process Involved In Female Pregnancy 14-3-3 Protein Binding Chromatin Organization Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Cellular Response To Lipid Negative Regulation Of Macroautophagy Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Toll-like Receptor Signaling Pathway Regulation Of Primary Metabolic Process Positive Regulation Of Nitric Oxide Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of TRNA Methylation Regulation Of Nitric Oxide Biosynthetic Process Protein Localization To Organelle Regulation Of Macromolecule Metabolic Process Regulation Of Nitric Oxide Metabolic Process Regulation Of RNA Metabolic Process Protein Modification By Small Protein Conjugation Negative Regulation Of Protein Localization To Lysosome Negative Regulation Of Aggrephagy Positive Regulation Of Protein Localization To Endoplasmic Reticulum Regulation Of Macromolecule Biosynthetic Process Response To Insulin-like Growth Factor Stimulus Cellular Response To Hormone Stimulus Post-translational Protein Modification Mammalian Oogenesis Stage Regulation Of Gene Expression Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Negative Regulation Of Autophagy TRNA (guanine-N7)-methylation Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process TORC2 Complex Binding Cellular Response To Rapamycin Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway