CLEC11A and KITLG

Number of citations of the paper that reports this interaction (PMID 11920266)
7

Data Source:
HPRD (in vitro)

		CLEC11A	KITLG
Gene Name		C-type lectin domain family 11, member A	KIT ligand
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm	Extracellular Region Extracellular Space Cytoplasm Cytoskeleton Plasma Membrane Integral Component Of Membrane
	Molecular Function	Growth Factor Activity Carbohydrate Binding	Cytokine Activity Stem Cell Factor Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	Positive Regulation Of Cell Proliferation	Neural Crest Cell Migration Positive Regulation Of Myeloid Leukocyte Differentiation Cell Adhesion Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Male Gonad Development Negative Regulation Of Mast Cell Apoptotic Process Embryonic Hemopoiesis Ectopic Germ Cell Programmed Cell Death Fc-epsilon Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity Innate Immune Response Positive Regulation Of Melanocyte Differentiation Positive Regulation Of DNA Replication Positive Regulation Of Ras Protein Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Mast Cell Proliferation Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways
Drugs
Diseases
GWAS			Blond vs. brown hair color ( 17952075) Hair color ( 23548203) Red blood cell traits ( 23222517) Testicular cancer ( 19483682) Testicular germ cell cancer ( 20543847) Testicular germ cell tumor ( 19483681 23666239 23666240)
Protein-Protein Interactions		1 interactors: KITLG	8 interactors: CLEC11A CMA1 CSF2 EPOR FLT3LG KIT PIK3CD UBE2V1
Entrez ID		6320	4254
HPRD ID		05277	01698
Ensembl ID		ENSG00000105472
Uniprot IDs		M0R081 Q9Y240	P21583
PDB IDs			1EXZ 1SCF 2E9W
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Mast Cell Apoptotic Process Regulation Of Mast Cell Apoptotic Process Positive Regulation Of Mast Cell Proliferation Positive Regulation Of Melanocyte Differentiation Regulation Of Melanocyte Differentiation Positive Regulation Of Pigment Cell Differentiation Ectopic Germ Cell Programmed Cell Death Positive Regulation Of Developmental Pigmentation Negative Regulation Of Myeloid Cell Apoptotic Process Regulation Of Developmental Pigmentation Embryonic Hemopoiesis Regulation Of Myeloid Cell Apoptotic Process Developmental Programmed Cell Death Neural Crest Cell Migration Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Myeloid Leukocyte Differentiation Negative Regulation Of Leukocyte Apoptotic Process Positive Regulation Of Ras Protein Signal Transduction Positive Regulation Of Small GTPase Mediated Signal Transduction Neural Crest Cell Development Positive Regulation Of DNA Replication Positive Regulation Of Epithelial Cell Differentiation Positive Regulation Of Myeloid Cell Differentiation Neural Crest Cell Differentiation Extrinsic Apoptotic Signaling Pathway Regulation Of Myeloid Leukocyte Differentiation Mesenchymal Cell Development Regulation Of DNA Replication Mesenchymal Cell Differentiation Phosphatidylinositol-mediated Signaling Regulation Of Epithelial Cell Differentiation Positive Regulation Of DNA Metabolic Process Positive Regulation Of Peptidyl-tyrosine Phosphorylation Male Gonad Development Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Myeloid Cell Differentiation Ameboidal-type Cell Migration Male Sex Differentiation Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Mesenchyme Development Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of MAP Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Gonad Development Development Of Primary Sexual Characteristics	Erythropoietin-mediated Signaling Pathway Mast Cell Differentiation Cellular Response To Erythropoietin Mast Cell Chemotaxis Leukocyte Differentiation Myeloid Leukocyte Differentiation Cytokine Production Leukocyte Activation Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Hemopoiesis Mast Cell Degranulation Cell Activation Mast Cell Mediated Immunity Fc-epsilon Receptor Signaling Pathway Immune System Development Embryonic Hemopoiesis Lysosome Localization Lymphocyte Differentiation Mast Cell Activation Myeloid Cell Differentiation Fc Receptor Signaling Pathway Leukocyte Degranulation Positive Regulation Of Cell Proliferation Organ Development Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulated Secretory Pathway Cellular Response To Organic Substance Positive Regulation Of JAK-STAT Cascade Immune Response-regulating Cell Surface Receptor Signaling Pathway Developmental Process Lymphocyte Activation Immune System Process Mast Cell Cytokine Production Melanocyte Adhesion Dendritic Cell Cytokine Production Error-free Postreplication DNA Repair Mast Cell Proliferation Interleukin-1 Beta Biosynthetic Process Immune Response-regulating Signaling Pathway Regulation Of JAK-STAT Cascade Embryonic Organ Development Reproductive Structure Development Reproductive System Development Immune Response Regulation Of Immune System Process Leukocyte Chemotaxis Response To Organic Substance T Cell Receptor Signaling Pathway System Development Kit Signaling Pathway
Tagcloud ?			agouti albinism asip atf1 delta25 dopachrome edn1 edn3 ednrb exoc2 exocyst ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkacb prkacg prkar1a prkar2a prkar2b proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1
Tagcloud (Difference) ?			agouti albinism asip atf1 delta25 dopachrome edn1 edn3 ednrb exoc2 exocyst ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkacb prkacg prkar1a prkar2a prkar2b proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1
Tagcloud (Intersection) ?