CLEC11A and KITLG

Number of citations of the paper that reports this interaction (PubMedID 11920266)
0

Data Source:
HPRD (in vitro)

		CLEC11A	KITLG
Description		C-type lectin domain containing 11A	KIT ligand
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm	Extracellular Region Extracellular Space Cytoplasm Cytoskeleton Plasma Membrane Membrane Lamellipodium Filopodium Cell Projection
	Molecular Function	Protein Binding Growth Factor Activity Carbohydrate Binding	Cytokine Activity Stem Cell Factor Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	Ossification Signal Transduction Positive Regulation Of Cell Population Proliferation	Ovarian Follicle Development Neural Crest Cell Migration Hematopoietic Progenitor Cell Differentiation Myeloid Leukocyte Differentiation Positive Regulation Of Leukocyte Migration Positive Regulation Of Myeloid Leukocyte Differentiation Developmental Process Involved In Reproduction Apoptotic Process Cell Adhesion Ras Protein Signal Transduction Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Male Gonad Development Mast Cell Apoptotic Process Negative Regulation Of Mast Cell Apoptotic Process Embryonic Hemopoiesis Ectopic Germ Cell Programmed Cell Death T Cell Proliferation Positive Regulation Of T Cell Proliferation Negative Regulation Of Apoptotic Process Positive Regulation Of Melanocyte Differentiation Positive Regulation Of Ras Protein Signal Transduction Animal Organ Development Mast Cell Proliferation Positive Regulation Of Mast Cell Proliferation Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Melanocyte Migration Mast Cell Migration Positive Regulation Of Hematopoietic Progenitor Cell Differentiation Positive Regulation Of Hematopoietic Stem Cell Proliferation
Pathways
Drugs
Diseases			Familial progressive hyperpigmentation
GWAS		Blood protein levels ( 30072576) Carotid plaque maximum area ( 32469969) Dietary fat liking ( 32516399) Stem cell growth factor beta levels ( 27989323) Sum of carotid plaque area ( 32469969) Sum of stenosis ( 32469969)	Aspartate aminotransferase levels ( 33547301) Blond vs non-blond hair color ( 26184321) Blond vs. brown hair color ( 17952075) Blond vs. brown/black hair color ( 30531825) Brown vs. black hair color ( 30531825) Brown vs. non-brown hair color ( 26184321) Facial skin colour (CIELAB index b* value) ( 34648798) Facial skin colour (CIELAB index L* value) ( 34648798) Hair color ( 23548203 29662168) Light vs. dark hair color ( 26184321) Mean corpuscular volume ( 32888494) Nevus count ( 30429480) Red blood cell traits ( 23222517) Testicular cancer ( 19483682) Testicular germ cell cancer ( 20543847) Testicular germ cell tumor ( 28604728 28604732 23666240 23666239 19483681) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		2 interacting genes: KITLG UBQLN2	9 interacting genes: CLEC11A CMA1 CSF2 EPOR FLT3LG KIT PIK3CD S100A6 UBE2V1
Entrez ID		6320	4254
HPRD ID		05277	01698
Ensembl ID		ENSG00000105472	ENSG00000049130
Uniprot IDs		Q9Y240	P21583
PDB IDs			1EXZ 1SCF 2E9W 8DFM 8DFP 8DFQ
Enriched GO Terms of Interacting Partners?		Mast Cell Apoptotic Process Regulation Of Melanocyte Differentiation Positive Regulation Of Mast Cell Proliferation Negative Regulation Of Mast Cell Apoptotic Process Melanocyte Migration Mast Cell Proliferation Regulation Of Mast Cell Apoptotic Process Stem Cell Factor Receptor Binding Positive Regulation Of Melanocyte Differentiation Vesicle Tethering To Endoplasmic Reticulum Endoplasmic Reticulum-endosome Membrane Contact Site Progesterone Biosynthetic Process Negative Regulation Of Clathrin-dependent Endocytosis Negative Regulation Of G Protein-coupled Receptor Internalization Mast Cell Migration Positive Regulation Of Pigment Cell Differentiation Positive Regulation Of Hematopoietic Progenitor Cell Differentiation Positive Regulation Of Developmental Pigmentation Regulation Of Mast Cell Proliferation Positive Regulation Of Hematopoietic Stem Cell Proliferation Organelle Membrane Contact Site C21-steroid Hormone Biosynthetic Process Myeloid Cell Apoptotic Process Regulation Of Hematopoietic Stem Cell Proliferation Regulation Of Developmental Pigmentation Ectopic Germ Cell Programmed Cell Death Positive Regulation Of Ras Protein Signal Transduction Progesterone Metabolic Process Positive Regulation Of ERAD Pathway Negative Regulation Of Receptor Internalization Regulation Of Clathrin-dependent Endocytosis Programmed Cell Death Involved In Cell Development Embryonic Hemopoiesis Negative Regulation Of Myeloid Cell Apoptotic Process Cholesterol Transfer Activity C21-steroid Hormone Metabolic Process Regulation Of ERAD Pathway Steroid Hormone Biosynthetic Process Vesicle Tethering Negative Regulation Of Receptor-mediated Endocytosis Regulation Of Myeloid Cell Apoptotic Process Ketone Biosynthetic Process Epithelial Cell Migration Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Mitochondrial Transport Hormone Biosynthetic Process Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Hematopoietic Progenitor Cell Differentiation Leukocyte Apoptotic Process	Positive Regulation Of Cell Population Proliferation Mast Cell Differentiation Mast Cell Chemotaxis Mast Cell Migration Erythropoietin-mediated Signaling Pathway Mononuclear Cell Differentiation Leukocyte Differentiation B Cell Differentiation Regulation Of Cell Population Proliferation Myeloid Leukocyte Differentiation Embryonic Hemopoiesis Embryonic Organ Development Positive Regulation Of Leukocyte Proliferation Mast Cell Degranulation B Cell Activation Leukocyte Activation Dendritic Cell Differentiation Leukocyte Degranulation Extracellular Region Cell Activation Lymphocyte Differentiation Myeloid Cell Differentiation Regulation Of Leukocyte Proliferation Developmental Process Extracellular Space Granulocyte Macrophage Colony-stimulating Factor Receptor Binding Erythropoietin Receptor Activity Lysosome Localization Positive Regulation Of Pyloric Antrum Smooth Muscle Contraction Melanocyte Adhesion Stem Cell Factor Receptor Activity Positive Regulation Of Colon Smooth Muscle Contraction Positive Regulation Of Multicellular Organismal Process Cytokine-mediated Signaling Pathway Error-free Postreplication DNA Repair Basement Membrane Disassembly Signal Transduction Lymphocyte Activation Regulated Exocytosis Cytoplasmic Side Of Plasma Membrane Kit Signaling Pathway Positive Regulation Of Small Intestine Smooth Muscle Contraction Melanocyte Migration Natural Killer Cell Chemotaxis UBC13-MMS2 Complex Positive Regulation Of Cytokine Production Secretion Granulocyte-macrophage Colony-stimulating Factor Signaling Pathway Granulocyte Macrophage Colony-stimulating Factor Receptor Complex Response To Silicon Dioxide
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