MIR98 and PUM1

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		MIR98	PUM1
Description		microRNA 98	pumilio RNA binding family member 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space RISC Complex	P-body Nucleoplasm Cytoplasm Cytosol Cytoplasmic Stress Granule Axon
	Molecular Function	MRNA 3'-UTR Binding MRNA Base-pairing Post-transcriptional Repressor Activity	RNA Binding MRNA 3'-UTR Binding Protein Binding MiRNA Binding
	Biological Process	Negative Regulation Of Cytokine Production Negative Regulation Of Cell Population Proliferation Negative Regulation Of Gene Expression Negative Regulation Of Extracellular Matrix Disassembly Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-10 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Interleukin-8 Production Negative Regulation Of Tumor Necrosis Factor Production MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By Inhibition Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Cholesterol Biosynthetic Process Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Interleukin-6-mediated Signaling Pathway Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Extracellular Matrix Assembly Cellular Response To Amyloid-beta Negative Regulation Of Myofibroblast Differentiation Negative Regulation Of Vascular Endothelial Cell Proliferation	Regulation Of Translation Spermatogenesis Adult Locomotory Behavior Post-transcriptional Regulation Of Gene Expression Post-transcriptional Gene Silencing Cell Differentiation MiRNA Processing Regulation Of MRNA Stability Stem Cell Differentiation Regulation Of Cell Cycle Regulation Of Chromosome Segregation Regulation Of MiRNA-mediated Gene Silencing MRNA Destabilization 3'-UTR-mediated MRNA Destabilization Positive Regulation Of RIG-I Signaling Pathway Positive Regulation Of MiRNA-mediated Gene Silencing
Pathways			Golgi Associated Vesicle Biogenesis
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756)	Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172)
Interacting Genes		77 interacting genes: ADARB1 APOBEC3B ATXN2L C1QBP CPSF1 DARS1 DDX1 DDX21 DDX3X DDX3Y DHX36 EDC4 EIF2AK2 EPRS1 ESRP1 FAM98A FUS G3BP2 GRSF1 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KNOP1 LARP7 LARS1 LIN28A LIN28B LRPPRC MARS1 MATR3 MSI1 MSI2 NOL6 NONO NUDT16L1 NUFIP2 PDCD11 PLOD1 PTBP1 PTBP3 PUM1 QARS1 RARS1 RBM12B RBM14 RTCB SAFB SF3B1 SF3B2 SF3B3 SFPQ STRBP SYNCRIP TAF15 TRA2A TRA2B TRIM25 TUT4 U2SURP UPF1 YBX1 YBX3 ZFR ZNF346	48 interacting genes: ATXN1 COPS5 EIF5 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR143 MIR145 MIR15B MIR17 MIR18B MIR199A1 MIR199A2 MIR19B1 MIR19B2 MIR200A MIR200B MIR206 MIR20A MIR20B MIR21 MIR214 MIR25 MIR29A MIR29C MIR34A MIR7-1 MIR9-3 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I PRR12 SMAD1
Entrez ID		407054	9698
HPRD ID			06230
Ensembl ID		ENSG00000271886	ENSG00000134644
Uniprot IDs			Q14671
PDB IDs			1IB2 1M8W 1M8X 1M8Y 1M8Z 2YJY 3BSB 3BSX 3Q0L 3Q0M 3Q0N 3Q0O 3Q0P 5YKH 5YKI
Enriched GO Terms of Interacting Partners?		RNA Binding Nucleic Acid Binding RNA Metabolic Process RNA Processing MRNA Metabolic Process Nucleic Acid Metabolic Process RNA Splicing MRNA Binding MRNA Processing Nucleobase-containing Compound Metabolic Process Regulation Of MRNA Metabolic Process Regulation Of RNA Splicing Ribonucleoprotein Complex Nucleus Cytoplasmic Stress Granule Macromolecule Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Post-transcriptional Regulation Of Gene Expression Nucleoplasm Negative Regulation Of MRNA Metabolic Process Spliceosomal Complex Catalytic Step 2 Spliceosome Aminoacyl-tRNA Synthetase Multienzyme Complex Regulation Of Gene Expression MiRNA Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Translation Negative Regulation Of RNA Catabolic Process Regulation Of RNA Stability MRNA 3'-UTR Binding Regulation Of MRNA Processing Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of MRNA Catabolic Process RNA Stabilization Regulation Of MRNA Stability MRNA Stabilization Regulation Of Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Cytoplasmic Translation Negative Regulation Of Macromolecule Metabolic Process TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity P-body Nucleolus TRNA Aminoacylation CRD-mediated MRNA Stabilization MRNA 5'-UTR Binding TRNA Metabolic Process	RISC Complex MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Metabolic Process Extracellular Vesicle Regulation Of Gene Expression Negative Regulation Of Translation Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Macromolecule Biosynthetic Process MRNA Destabilization RNA Destabilization Positive Regulation Of MRNA Catabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cytokine Production Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Developmental Process Regulation Of Angiogenesis Regulation Of Metabolic Process Negative Regulation Of Cell Migration Regulation Of Vasculature Development Negative Regulation Of Angiogenesis Negative Regulation Of Cell Motility Regulation Of Translation Negative Regulation Of Vasculature Development Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Locomotion Regulation Of MRNA Stability Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of RNA Stability Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Multicellular Organismal Process Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Protein Metabolic Process Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Signal Transduction Regulation Of Endothelial Cell Migration Regulation Of MRNA Metabolic Process Negative Regulation Of Cell Communication
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