RRM1 and SH2D3A

		RRM1	SH2D3A
Description		ribonucleotide reductase catalytic subunit M1	SH2 domain containing 3A
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Envelope Cytoplasm Mitochondrion Cytosol Ribonucleoside-diphosphate Reductase Complex Centriolar Satellite Ciliary Basal Body Cell Projection Neuronal Cell Body
	Molecular Function	Nucleotide Binding Catalytic Activity Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Protein Binding ATP Binding Oxidoreductase Activity Purine Nucleotide Binding Identical Protein Binding Ribonucleoside-diphosphate Reductase Activity Disordered Domain Specific Binding	Phosphotyrosine Residue Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	DNA Synthesis Involved In DNA Repair Pyrimidine Nucleobase Metabolic Process Mitochondrial DNA Replication DNA Repair Male Gonad Development Ribonucleoside Diphosphate Metabolic Process Deoxyribonucleotide Biosynthetic Process 2'-deoxyribonucleotide Biosynthetic Process Response To Ionizing Radiation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Cell Proliferation In Forebrain Protein Heterotetramerization Retina Development In Camera-type Eye Positive Regulation Of G0 To G1 Transition Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle	JNK Cascade Small GTPase-mediated Signal Transduction
Pathways		Interconversion of nucleotide di- and triphosphates
Drugs		Cladribine Gemcitabine Clofarabine Hydroxyurea Fludarabine Imexon Gallium maltolate Tezacitabine
Diseases
GWAS		Malaria ( 31844061) Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 27863252 28957414 32888494)
Interacting Genes		11 interacting genes: BMI1 CDC42 CEBPA LRIF1 PPP1CC RNF2 RRM2 RRM2B SUMO2 YWHAG ZNF655	7 interacting genes: BCAR1 CENPB EGFR ERBB2 ERBB3 GAB1 NXF1
Entrez ID		6240	10045
HPRD ID		01588	05283
Ensembl ID		ENSG00000167325	ENSG00000125731
Uniprot IDs		B4DXD1 B4E0I8 E9PL69 P23921	A8K2M8 Q9BRG2
PDB IDs		2WGH 3HNC 3HND 3HNE 3HNF 4X3V 5D1Y 5TUS 6AUI 6L3R 6L7L 6LKM
Enriched GO Terms of Interacting Partners?		RING-like Zinc Finger Domain Binding Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Ribonucleoside-diphosphate Reductase Complex Deoxyribonucleotide Biosynthetic Process 2'-deoxyribonucleotide Biosynthetic Process Regulation Of Store-operated Calcium Entry PRC1 Complex	Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway ERBB2 Signaling Pathway ERBB3:ERBB2 Complex Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway ErbB-3 Class Receptor Binding Basal Plasma Membrane ERBB2-EGFR Signaling Pathway ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Tyrosine Kinase Activator Activity Protein Tyrosine Kinase Activity Schwann Cell Development Peripheral Nervous System Development Receptor Complex Positive Regulation Of Epithelial Cell Proliferation Cell Surface Receptor Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Transmembrane Signaling Receptor Activity Basolateral Plasma Membrane Growth Factor Binding Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Transmembrane Receptor Protein Tyrosine Kinase Activity Response To Epidermal Growth Factor Cellular Response To Growth Factor Stimulus Animal Organ Development Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Cycle G1/S Phase Transition Response To Growth Factor Multivesicular Body, Internal Vesicle Lumen Regulation Of Angiogenesis Glial Cell Development Ribonucleoside-diphosphate Reductase Activity Regulation Of Vasculature Development Wound Healing Neuron Differentiation Cell Migration Insulin Receptor Signaling Pathway Regulation Of Epithelial Cell Proliferation Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Growth Ruffle Membrane Focal Adhesion Shc-EGFR Complex Myelination Axon Ensheathment Positive Regulation Of Cardiac Muscle Tissue Development
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