RREB1 and NEUROD1

Number of citations: 42 (PubMedID 12482979)
Data Source: HPRD (in vitro)

		RREB1	NEUROD1
Name		ras responsive element binding protein 1	neuronal differentiation 1
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleus Cytoplasm Nuclear Body Nuclear Speck Extracellular Exosome	Chromatin Nucleus Nucleoplasm Cytoplasm RNA Polymerase II Transcription Regulator Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Zinc Ion Binding Metal Ion Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Protein Heterodimerization Activity Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding E-box Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Mammary Gland Epithelial Cell Proliferation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Developmental Process Positive Regulation Of Brown Fat Cell Differentiation Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Wound Healing, Spreading Of Epidermal Cells Positive Regulation Of Lamellipodium Morphogenesis	Pancreatic A Cell Fate Commitment Pancreatic PP Cell Fate Commitment Regulation Of DNA-templated Transcription Transcription By RNA Polymerase II Cell Surface Receptor Signaling Pathway Via JAK-STAT Nervous System Development Sensory Organ Development Response To Glucose Anterior/posterior Pattern Specification Dentate Gyrus Development Cerebellum Development Neurogenesis Signal Transduction Involved In Regulation Of Gene Expression Insulin Secretion Cell Differentiation Hindbrain Development Endocrine Pancreas Development Positive Regulation Of Insulin Secretion Amacrine Cell Differentiation Enteroendocrine Cell Differentiation Glucose Homeostasis Camera-type Eye Development Positive Regulation Of Apoptotic Process Cell Fate Commitment Positive Regulation Of Cell Differentiation Regulation Of Neuron Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Embryonic Organ Morphogenesis Inner Ear Development Regulation Of Insulin Secretion Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Intestinal Epithelial Structure Maintenance Axon Development Cellular Response To Glucocorticoid Stimulus Negative Regulation Of Type B Pancreatic Cell Apoptotic Process
Pathways		None	Regulation of gene expression in beta cells Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells
Diseases		None	Maturity onset diabetes of the young (MODY)
GWAS		A body shape index ( 34021172 ) Age-related macular degeneration ( 20385826 ) Appendicular lean mass ( 33097823 ) Birth weight ( 31043758 ) Blood glucose levels ( 31928498 ) Brain morphology (MOSTest) ( 32665545 ) Chronic kidney disease ( 29124443 ) Chronic lymphocytic leukemia or multiple sclerosis ( 31407831 ) Chronic obstructive pulmonary disease ( 33909500 30804561 ) Estimated glomerular filtration rate ( 31451708 31152163 29124443 ) Ewing sarcoma ( 30093639 ) Fasting blood glucose ( 22581228 ) Fasting blood glucose (BMI interaction) ( 22581228 ) Fasting blood glucose adjusted for BMI ( 25625282 ) Fasting glucose ( 34059833 ) Glycated hemoglobin levels ( 34059833 ) Gout ( 33832965 ) HDL cholesterol levels ( 32203549 ) Heel bone mineral density ( 28869591 30598549 ) Height ( 28552196 31562340 ) Hematocrit ( 27863252 32888494 ) Hemoglobin ( 32888494 ) Hemoglobin concentration ( 27863252 ) Hemoglobin levels ( 32327693 ) High density lipoprotein cholesterol levels ( 31928498 ) High light scatter reticulocyte count ( 27863252 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Hip circumference adjusted for BMI ( 34021172 ) Hyperuricemia ( 29124443 ) Immature fraction of reticulocytes ( 32888494 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 ) Lymphocyte count ( 27863252 32888494 ) Mean corpuscular volume ( 32888494 ) Medication use (drugs used in diabetes) ( 31015401 ) Monocyte count ( 32888494 27863252 ) Multiple sclerosis ( 21833088 ) Multiple system atrophy ( 27629089 ) Myeloid white cell count ( 27863252 ) Neutrophil count ( 32888494 27863252 ) Offspring birth weight ( 31043758 ) Pulse pressure ( 30578418 30224653 ) Red blood cell count ( 27863252 32888494 ) Refractive error ( 32231278 ) Reticulocyte count ( 32888494 27863252 ) Reticulocyte fraction of red cells ( 32888494 27863252 ) Serum alkaline phosphatase levels ( 33547301 ) Serum uric acid levels ( 30993211 29124443 ) Subcortical volume (MOSTest) ( 32665545 ) Sum basophil neutrophil counts ( 27863252 ) Triglyceride levels ( 32203549 ) Type 2 diabetes ( 30054458 24509480 32499647 29632382 30297969 30718926 ) Type 2 diabetes (adjusted for BMI) ( 29632382 ) Urate levels ( 23263486 20884846 31578528 31985003 ) Vertical cup-disc ratio ( 28073927 ) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993 ) Vertical cup-disc ratio (multi-trait analysis) ( 31959993 ) Visceral adipose tissue adjusted for BMI ( 27918534 22589738 ) Visceral adipose tissue/subcutaneous adipose tissue ratio adjusted for BMI ( 27918534 ) Waist-hip index ( 34021172 ) Waist-hip ratio ( 23966867 ) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172 ) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226 ) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 ) White blood cell count ( 32888494 27863252 )	Glucosuria ( 30476138 ) Glucosuria (moderate to severe) ( 30476138 )
Interacting Genes		3 interacting genes: H3-4 NEUROD1 SUMO2	15 interacting genes: CALM1 CALM2 CALM3 DUSP3 EP300 HAP1 MAFA MAP3K10 NR0B2 PDX1 PITX1 RREB1 TCF12 TCF3 TCF4
Entrez ID		6239	4760
HPRD ID		03733	03428
Ensembl ID		ENSG00000124782	ENSG00000162992
Uniprot IDs		Q92766	A0A0S2Z493 Q13562
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Pancreatic A Cell Fate Commitment Regulation Of Intestinal Epithelial Structure Maintenance Pancreatic PP Cell Fate Commitment Protein Heterodimerization Activity Negative Regulation Of Type B Pancreatic Cell Apoptotic Process DNA Replication-dependent Chromatin Assembly Spermatogonial Cell Division	Transporter Inhibitor Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Titin Binding Detection Of Calcium Ion Regulation Of Cell Communication By Electrical Coupling Protein Phosphatase Activator Activity Regulation Of Transmembrane Transporter Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Calyx Of Held Regulation Of Monoatomic Ion Transmembrane Transporter Activity DNA-binding Transcription Factor Activity Catalytic Complex Chromatin Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Negative Regulation Of Transporter Activity Calcium Channel Complex Transcription Regulator Complex Calcineurin-mediated Signaling Presynaptic Cytosol BHLH Transcription Factor Binding Myelin Sheath Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Sequestering Of Calcium Ion Positive Regulation Of RNA Metabolic Process Negative Regulation Of Calcium Ion Transmembrane Transport Transmembrane Transporter Binding Spindle Microtubule Positive Regulation Of Synaptic Transmission Regulation Of Calcium Ion Transmembrane Transport Presynaptic Endocytosis Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Substantia Nigra Development RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Calcium Channel Regulator Activity Nucleus Sperm Midpiece Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Calcium Ion Transport G2/M Transition Of Mitotic Cell Cycle