RREB1

Name	ras responsive element binding protein 1
Structure	No pdb structure
Interactors	3 interactors: H3-4 NEUROD1 SUMO2
GO Annotations	Cellular Component	Fibrillar Center Nucleus Cytoplasm Nuclear Body Nuclear Speck Extracellular Exosome
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Zinc Ion Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Mammary Gland Epithelial Cell Proliferation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Developmental Process Positive Regulation Of Brown Fat Cell Differentiation Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Wound Healing, Spreading Of Epidermal Cells Positive Regulation Of Lamellipodium Morphogenesis
GWAS	A body shape index ( 34021172 ) Age-related macular degeneration ( 20385826 ) Appendicular lean mass ( 33097823 ) Birth weight ( 31043758 ) Blood glucose levels ( 31928498 ) Brain morphology (MOSTest) ( 32665545 ) Chronic kidney disease ( 29124443 ) Chronic lymphocytic leukemia or multiple sclerosis ( 31407831 ) Chronic obstructive pulmonary disease ( 33909500 30804561 ) Estimated glomerular filtration rate ( 31451708 31152163 29124443 ) Ewing sarcoma ( 30093639 ) Fasting blood glucose ( 22581228 ) Fasting blood glucose (BMI interaction) ( 22581228 ) Fasting blood glucose adjusted for BMI ( 25625282 ) Fasting glucose ( 34059833 ) Glycated hemoglobin levels ( 34059833 ) Gout ( 33832965 ) HDL cholesterol levels ( 32203549 ) Heel bone mineral density ( 28869591 30598549 ) Height ( 28552196 31562340 ) Hematocrit ( 27863252 32888494 ) Hemoglobin ( 32888494 ) Hemoglobin concentration ( 27863252 ) Hemoglobin levels ( 32327693 ) High density lipoprotein cholesterol levels ( 31928498 ) High light scatter reticulocyte count ( 27863252 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Hip circumference adjusted for BMI ( 34021172 ) Hyperuricemia ( 29124443 ) Immature fraction of reticulocytes ( 32888494 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 ) Lymphocyte count ( 27863252 32888494 ) Mean corpuscular volume ( 32888494 ) Medication use (drugs used in diabetes) ( 31015401 ) Monocyte count ( 32888494 27863252 ) Multiple sclerosis ( 21833088 ) Multiple system atrophy ( 27629089 ) Myeloid white cell count ( 27863252 ) Neutrophil count ( 32888494 27863252 ) Offspring birth weight ( 31043758 ) Pulse pressure ( 30578418 30224653 ) Red blood cell count ( 27863252 32888494 ) Refractive error ( 32231278 ) Reticulocyte count ( 32888494 27863252 ) Reticulocyte fraction of red cells ( 32888494 27863252 ) Serum alkaline phosphatase levels ( 33547301 ) Serum uric acid levels ( 30993211 29124443 ) Subcortical volume (MOSTest) ( 32665545 ) Sum basophil neutrophil counts ( 27863252 ) Triglyceride levels ( 32203549 ) Type 2 diabetes ( 30054458 24509480 32499647 29632382 30297969 30718926 ) Type 2 diabetes (adjusted for BMI) ( 29632382 ) Urate levels ( 23263486 20884846 31578528 31985003 ) Vertical cup-disc ratio ( 28073927 ) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993 ) Vertical cup-disc ratio (multi-trait analysis) ( 31959993 ) Visceral adipose tissue adjusted for BMI ( 27918534 22589738 ) Visceral adipose tissue/subcutaneous adipose tissue ratio adjusted for BMI ( 27918534 ) Waist-hip index ( 34021172 ) Waist-hip ratio ( 23966867 ) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172 ) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226 ) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 ) White blood cell count ( 32888494 27863252 )
Entrez ID	6239
HPRD ID	03733
Ensembl ID	ENSG00000124782
Uniprot IDs	Q92766
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Pancreatic A Cell Fate Commitment Regulation Of Intestinal Epithelial Structure Maintenance Pancreatic PP Cell Fate Commitment Protein Heterodimerization Activity Negative Regulation Of Type B Pancreatic Cell Apoptotic Process DNA Replication-dependent Chromatin Assembly Spermatogonial Cell Division