HCN2 and HCN4

Number of citations of the paper that reports this interaction (PubMedID 12928435)
0

Data Source:
HPRD (in vivo, in vitro)

		HCN2	HCN4
Description		hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2	hyperpolarization activated cyclic nucleotide gated potassium channel 4
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GO Annotations	Cellular Component	Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Axon Dendrite Dendrite Membrane Monoatomic Ion Channel Complex Somatodendritic Compartment Neuronal Cell Body Dendritic Shaft HCN Channel Complex	Plasma Membrane Membrane Axon Dendrite Monoatomic Ion Channel Complex Perinuclear Region Of Cytoplasm HCN Channel Complex
	Molecular Function	Nucleotide Binding Monoatomic Ion Channel Activity Intracellularly CAMP-activated Cation Channel Activity Voltage-gated Sodium Channel Activity Voltage-gated Potassium Channel Activity Potassium Channel Activity Sodium Channel Activity Protein Binding PDZ Domain Binding CAMP Binding Identical Protein Binding Protein-containing Complex Binding Molecular Adaptor Activity	Nucleotide Binding Monoatomic Ion Channel Activity Intracellularly CAMP-activated Cation Channel Activity Voltage-gated Sodium Channel Activity Voltage-gated Potassium Channel Activity Potassium Channel Activity Sodium Channel Activity Protein Binding CAMP Binding Identical Protein Binding Voltage-gated Potassium Channel Activity Involved In SA Node Cell Action Potential Depolarization
	Biological Process	Regulation Of Membrane Depolarization Monoatomic Ion Transport Potassium Ion Transport Sodium Ion Transport Cell-cell Signaling Response To Xenobiotic Stimulus Response To Hormone Monoatomic Ion Transmembrane Transport Sodium Ion Transmembrane Transport Regulation Of Membrane Potential Transmembrane Transport Cellular Response To CAMP Cellular Response To CGMP Potassium Ion Transmembrane Transport Ammonium Transmembrane Transport Membrane Depolarization During Cardiac Muscle Cell Action Potential Sodium Ion Import Across Plasma Membrane Cellular Response To Aldosterone Potassium Ion Import Across Plasma Membrane	Regulation Of Heart Rate Sinoatrial Node Development Regulation Of Membrane Depolarization Monoatomic Ion Transport Monoatomic Cation Transport Potassium Ion Transport Sodium Ion Transport Muscle Contraction Blood Circulation Monoatomic Ion Transmembrane Transport Sodium Ion Transmembrane Transport Regulation Of Membrane Potential Transmembrane Transport Regulation Of Cardiac Muscle Contraction Cellular Response To CAMP Cellular Response To CGMP Potassium Ion Transmembrane Transport Membrane Depolarization During Cardiac Muscle Cell Action Potential SA Node Cell Action Potential Membrane Depolarization During SA Node Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Sodium Ion Import Across Plasma Membrane Regulation Of SA Node Cell Action Potential Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Potassium Ion Import Across Plasma Membrane
Pathways		HCN channels	HCN channels
Drugs		Cyclic GMP Cyclic adenosine monophosphate Ivabradine
Diseases			Brugada syndrome (BRS) Sick sinus syndrome (SSS); Sinus node dysfunction
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847)	Atrial fibrillation ( 22544366 30061737 29892015 28416818) Brain morphology (MOSTest) ( 32665545) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heart rate ( 23583979) Heart rate variability traits (pvRSA/HF) ( 28613276) Heart rate variability traits (RMSSD) ( 28613276) Heart rate variability traits (SDNN) ( 28613276) Heel bone mineral density ( 30598549) Nickel levels ( 26025379) PR interval ( 32439900) Resting heart rate ( 29769521 27798624) Triglyceride levels ( 32203549) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		3 interacting genes: HCN1 HCN4 KCNE2	2 interacting genes: HCN2 KCNE2
Entrez ID		610	10021
HPRD ID		07213	09240
Ensembl ID		ENSG00000099822	ENSG00000138622
Uniprot IDs		Q9UL51	Q9Y3Q4
PDB IDs		2MPF 3U10	2MNG 3OTF 3U11 4HBN 4KL1 4NVP 6GYN 6GYO
Enriched GO Terms of Interacting Partners?		Voltage-gated Potassium Channel Activity Regulation Of Heart Rate By Cardiac Conduction Potassium Ion Import Across Plasma Membrane Cardiac Conduction HCN Channel Complex Potassium Channel Activity Regulation Of SA Node Cell Action Potential Inorganic Cation Import Across Plasma Membrane Regulation Of Heart Rate Action Potential Intracellularly CAMP-activated Cation Channel Activity Monoatomic Ion Channel Complex Import Across Plasma Membrane Potassium Ion Transmembrane Transport Potassium Ion Transport Voltage-gated Sodium Channel Activity Regulation Of Heart Contraction CAMP Binding Sodium Ion Import Across Plasma Membrane Regulation Of Blood Circulation Regulation Of Cardiac Muscle Cell Action Potential Sodium Channel Activity Cardiac Muscle Cell Action Potential Regulation Of Membrane Depolarization Regulation Of Membrane Potential Cellular Response To CAMP Regulation Of Action Potential Regulation Of System Process Metal Ion Transport Response To CAMP Import Into Cell Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Voltage-gated Potassium Channel Activity Involved In SA Node Cell Action Potential Depolarization Intracellular CAMP-activated Cation Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Inorganic Ion Transmembrane Transport Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Sodium Ion Transmembrane Transport Response To Purine-containing Compound Positive Regulation Of Membrane Hyperpolarization Monoatomic Ion Channel Activity Monoatomic Ion Transport Sodium Ion Transport Transmembrane Transport Membrane Depolarization During SA Node Cell Action Potential Negative Regulation Of Action Potential Regulation Of Membrane Hyperpolarization General Adaptation Syndrome, Behavioral Process SA Node Cell Action Potential	Voltage-gated Potassium Channel Activity Potassium Ion Import Across Plasma Membrane Potassium Channel Activity Inorganic Cation Import Across Plasma Membrane Voltage-gated Potassium Channel Complex Monoatomic Ion Channel Complex Import Across Plasma Membrane Potassium Ion Transmembrane Transport Potassium Ion Transport Response To Xenobiotic Stimulus HCN Channel Complex Cellular Response To CGMP Ammonium Transmembrane Transport Import Into Cell Monoatomic Cation Transmembrane Transport Metal Ion Transport Inorganic Cation Transmembrane Transport Regulation Of Membrane Potential Cellular Response To Aldosterone Intracellularly CAMP-activated Cation Channel Activity Response To CGMP Regulation Of Delayed Rectifier Potassium Channel Activity Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Voltage-gated Potassium Channel Activity Negative Regulation Of Delayed Rectifier Potassium Channel Activity Cellular Response To Mineralocorticoid Stimulus Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Ventricular Cardiac Muscle Cell Membrane Repolarization Somatodendritic Compartment Membrane Depolarization During Cardiac Muscle Cell Action Potential Voltage-gated Sodium Channel Activity Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Inorganic Ion Transmembrane Transport Response To Aldosterone Ventricular Cardiac Muscle Cell Action Potential Potassium Ion Export Across Plasma Membrane CAMP Binding Membrane Depolarization During Action Potential Membrane Repolarization During Action Potential Negative Regulation Of Potassium Ion Transmembrane Transport Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Membrane Repolarization During Cardiac Muscle Cell Action Potential Delayed Rectifier Potassium Channel Activity Inward Rectifier Potassium Channel Activity Sodium Ion Import Across Plasma Membrane Monoatomic Ion Transport Negative Regulation Of Transporter Activity Membrane Repolarization
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