HCN2 and KCNE2

Number of citations of the paper that reports this interaction (PubMedID 12856183)
0

Data Source:
BioGRID (two hybrid)

		HCN2	KCNE2
Description		hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2	potassium voltage-gated channel subfamily E regulatory subunit 2
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GO Annotations	Cellular Component	Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Axon Dendrite Dendrite Membrane Monoatomic Ion Channel Complex Somatodendritic Compartment Neuronal Cell Body Dendritic Shaft HCN Channel Complex	Lysosome Plasma Membrane Voltage-gated Potassium Channel Complex Cell Surface Membrane Apical Plasma Membrane Monoatomic Ion Channel Complex
	Molecular Function	Nucleotide Binding Monoatomic Ion Channel Activity Intracellularly CAMP-activated Cation Channel Activity Voltage-gated Sodium Channel Activity Voltage-gated Potassium Channel Activity Potassium Channel Activity Sodium Channel Activity Protein Binding PDZ Domain Binding CAMP Binding Identical Protein Binding Protein-containing Complex Binding Molecular Adaptor Activity	Inward Rectifier Potassium Channel Activity Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Potassium Channel Activity Protein Binding Potassium Channel Regulator Activity Transmembrane Transporter Binding Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization
	Biological Process	Regulation Of Membrane Depolarization Monoatomic Ion Transport Potassium Ion Transport Sodium Ion Transport Cell-cell Signaling Response To Xenobiotic Stimulus Response To Hormone Monoatomic Ion Transmembrane Transport Sodium Ion Transmembrane Transport Regulation Of Membrane Potential Transmembrane Transport Cellular Response To CAMP Cellular Response To CGMP Potassium Ion Transmembrane Transport Ammonium Transmembrane Transport Membrane Depolarization During Cardiac Muscle Cell Action Potential Sodium Ion Import Across Plasma Membrane Cellular Response To Aldosterone Potassium Ion Import Across Plasma Membrane	Monoatomic Ion Transport Potassium Ion Transport Monoatomic Ion Transmembrane Transport Regulation Of Membrane Repolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Cellular Response To Xenobiotic Stimulus Potassium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Involved In Contraction Ventricular Cardiac Muscle Cell Action Potential Membrane Repolarization Membrane Repolarization During Action Potential Regulation Of Heart Rate By Cardiac Conduction Potassium Ion Export Across Plasma Membrane Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Delayed Rectifier Potassium Channel Activity Potassium Ion Import Across Plasma Membrane
Pathways		HCN channels	Phase 3 - rapid repolarisation Phase 2 - plateau phase
Drugs		Cyclic GMP Cyclic adenosine monophosphate Ivabradine	Enflurane Promethazine Miconazole
Diseases			Atrial fibrillation Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847)	Body mass index (smoking years interaction) ( 23192594) Cancer ( 29299148) Chronic obstructive pulmonary disease ( 30804561) Coronary artery disease ( 28714974 33020668 32469254 26343387 24262325) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Heel bone mineral density ( 28869591 30598549) Height ( 31562340 20881960) Joint mobility (Beighton score) ( 27182965) Lung function (FEV1/FVC) ( 28166213 30804560) Myocardial infarction ( 26343387 26708285) Myocardial infarction (early onset) ( 19198609) Pulmonary function ( 21946350)
Interacting Genes		3 interacting genes: HCN1 HCN4 KCNE2	4 interacting genes: HCN2 HCN4 KCNH2 KCNQ1
Entrez ID		610	9992
HPRD ID		07213	04813
Ensembl ID		ENSG00000099822	ENSG00000159197
Uniprot IDs		Q9UL51	Q9Y6J6
PDB IDs		2MPF 3U10	2M0Q
Enriched GO Terms of Interacting Partners?		Voltage-gated Potassium Channel Activity Regulation Of Heart Rate By Cardiac Conduction Potassium Ion Import Across Plasma Membrane Cardiac Conduction HCN Channel Complex Potassium Channel Activity Regulation Of SA Node Cell Action Potential Inorganic Cation Import Across Plasma Membrane Regulation Of Heart Rate Action Potential Intracellularly CAMP-activated Cation Channel Activity Monoatomic Ion Channel Complex Import Across Plasma Membrane Potassium Ion Transmembrane Transport Potassium Ion Transport Voltage-gated Sodium Channel Activity Regulation Of Heart Contraction CAMP Binding Sodium Ion Import Across Plasma Membrane Regulation Of Blood Circulation Regulation Of Cardiac Muscle Cell Action Potential Sodium Channel Activity Cardiac Muscle Cell Action Potential Regulation Of Membrane Depolarization Regulation Of Membrane Potential Cellular Response To CAMP Regulation Of Action Potential Regulation Of System Process Metal Ion Transport Response To CAMP Import Into Cell Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Voltage-gated Potassium Channel Activity Involved In SA Node Cell Action Potential Depolarization Intracellular CAMP-activated Cation Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Inorganic Ion Transmembrane Transport Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Sodium Ion Transmembrane Transport Response To Purine-containing Compound Positive Regulation Of Membrane Hyperpolarization Monoatomic Ion Channel Activity Monoatomic Ion Transport Sodium Ion Transport Transmembrane Transport Membrane Depolarization During SA Node Cell Action Potential Negative Regulation Of Action Potential Regulation Of Membrane Hyperpolarization General Adaptation Syndrome, Behavioral Process SA Node Cell Action Potential	Potassium Ion Import Across Plasma Membrane Voltage-gated Potassium Channel Activity Potassium Channel Activity Inorganic Cation Import Across Plasma Membrane Monoatomic Ion Channel Complex Import Across Plasma Membrane Potassium Ion Transmembrane Transport Membrane Depolarization During Action Potential Monoatomic Ion Channel Activity Potassium Ion Transport Regulation Of Heart Rate By Cardiac Conduction Cardiac Muscle Cell Action Potential Cardiac Conduction Membrane Depolarization HCN Channel Complex Cellular Response To CAMP Voltage-gated Potassium Channel Complex Regulation Of Membrane Potential Response To CAMP Cellular Response To CGMP Regulation Of Heart Rate Action Potential Intracellularly CAMP-activated Cation Channel Activity Metal Ion Transport Import Into Cell Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Response To CGMP Response To Purine-containing Compound Inorganic Ion Transmembrane Transport Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Ventricular Cardiac Muscle Cell Membrane Repolarization Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Potassium Ion Export Across Plasma Membrane Sodium Ion Transport Membrane Depolarization During Cardiac Muscle Cell Action Potential Voltage-gated Sodium Channel Activity Ventricular Cardiac Muscle Cell Action Potential Regulation Of Heart Contraction Muscle Contraction CAMP Binding Monoatomic Ion Transport Membrane Repolarization During Cardiac Muscle Cell Action Potential Delayed Rectifier Potassium Channel Activity Membrane Repolarization During Action Potential Negative Regulation Of Potassium Ion Transmembrane Transport Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Sodium Ion Import Across Plasma Membrane
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