HCN2

Description		hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2
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GO Annotations	Cellular Component	Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Axon Dendrite Dendrite Membrane Monoatomic Ion Channel Complex Somatodendritic Compartment Neuronal Cell Body Dendritic Shaft HCN Channel Complex
	Molecular Function	Nucleotide Binding Monoatomic Ion Channel Activity Intracellularly CAMP-activated Cation Channel Activity Voltage-gated Sodium Channel Activity Voltage-gated Potassium Channel Activity Potassium Channel Activity Sodium Channel Activity Protein Binding PDZ Domain Binding CAMP Binding Identical Protein Binding Protein-containing Complex Binding Molecular Adaptor Activity
	Biological Process	Regulation Of Membrane Depolarization Monoatomic Ion Transport Potassium Ion Transport Sodium Ion Transport Cell-cell Signaling Response To Xenobiotic Stimulus Response To Hormone Monoatomic Ion Transmembrane Transport Sodium Ion Transmembrane Transport Regulation Of Membrane Potential Transmembrane Transport Cellular Response To CAMP Cellular Response To CGMP Potassium Ion Transmembrane Transport Ammonium Transmembrane Transport Membrane Depolarization During Cardiac Muscle Cell Action Potential Sodium Ion Import Across Plasma Membrane Cellular Response To Aldosterone Potassium Ion Import Across Plasma Membrane
Pathways		HCN channels
Drugs		Cyclic GMP Cyclic adenosine monophosphate Ivabradine
Diseases
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847)
Novel Interacting Genes		1 novel interacting genes: TLE5
Interacting Genes		3 interacting genes: HCN1 HCN4 KCNE2
Entrez ID		610
HPRD ID		07213
Ensembl ID		ENSG00000099822
Uniprot IDs		Q9UL51
PDB IDs		2MPF 3U10
Enriched GO Terms of Interacting Partners?		Voltage-gated Potassium Channel Activity Regulation Of Heart Rate By Cardiac Conduction Potassium Ion Import Across Plasma Membrane Cardiac Conduction HCN Channel Complex Potassium Channel Activity Regulation Of SA Node Cell Action Potential Inorganic Cation Import Across Plasma Membrane Regulation Of Heart Rate Action Potential Intracellularly CAMP-activated Cation Channel Activity Monoatomic Ion Channel Complex Import Across Plasma Membrane Potassium Ion Transmembrane Transport Potassium Ion Transport Voltage-gated Sodium Channel Activity Regulation Of Heart Contraction CAMP Binding Sodium Ion Import Across Plasma Membrane Regulation Of Blood Circulation Regulation Of Cardiac Muscle Cell Action Potential Sodium Channel Activity Cardiac Muscle Cell Action Potential Regulation Of Membrane Depolarization Regulation Of Membrane Potential Cellular Response To CAMP Regulation Of Action Potential Regulation Of System Process Metal Ion Transport Response To CAMP Import Into Cell Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Voltage-gated Potassium Channel Activity Involved In SA Node Cell Action Potential Depolarization Intracellular CAMP-activated Cation Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Inorganic Ion Transmembrane Transport Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Sodium Ion Transmembrane Transport Response To Purine-containing Compound Positive Regulation Of Membrane Hyperpolarization Monoatomic Ion Channel Activity Monoatomic Ion Transport Sodium Ion Transport Transmembrane Transport Membrane Depolarization During SA Node Cell Action Potential Negative Regulation Of Action Potential Regulation Of Membrane Hyperpolarization General Adaptation Syndrome, Behavioral Process SA Node Cell Action Potential
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